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Marine Enzymes
Marine enzyme biotechnology can offer novel biocatalysts with properties like high salt tolerance, hyperthermostability, barophilicity, cold...
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Liver Regeneration
This review summarizes the functional aspects, cellular kinetics and molecular mechanisms related to liver regeneration. Liver regeneration is a...
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Enzymes of Industrial Significance and Their Applications
Enzymes play an enormous role in enriching and saving various forms of life on earth including humans. Enzymes also called biological catalysts have...
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Beneficial effects of WON-21 on the symptoms of a hangover and identification of active compounds: experimental studies on antioxidant, anti-inflammation, and alcohol-metabolizing enzymes
Many hangover cure products containing natural ingredients that are also effective against alcohol-related liver damage or improve liver function...
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Fish oil supplementation during pregnancy decreases liver endocannabinoid system and lipogenic markers in newborn rats exposed to maternal high-fat diet
PurposeMaternal high-fat diet (HF) programs obesity, metabolic dysfunction-associated steatotic liver disease (MASLD), hypertriglyceridemia, and...
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Antioxidant and angiotensin-I-converting enzyme (ACE-I) inhibitory activities of protein hydrolysates derived from water buffalo (Bubalus bubalis) liver
In the current study, we attempted to use ginger as a novel and natural source of protease in comparison with other commercially available enzymes to...
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Thymoquinone mitigates obesity and diabetic parameters through regulation of major adipokines, key lipid metabolizing enzymes and AMPK/p-AMPK in diet-induced obese rats
The present study was designed to evaluate the anti-obesity and anti-hyperglycemic activity of Thymoquinone (ThyQ) isolated from Nigella sativa ...
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Geraniol alleviates liver injury induced by bisphenol A via modulating NLRP3/caspase-1 pathway and gut microbiota in mice model
Bisphenol A has become a global public health problem. As an antioxidant, geraniol has potential preventive effects against toxicity. This study...
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Structure and function of aldopentose catabolism enzymes involved in oxidative non-phosphorylative pathways
Platform chemicals and polymer precursors can be produced via enzymatic pathways starting from lignocellulosic waste materials. The hemicellulose...
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Anticancer Effect of Ruscogenin in B(a)P-Induced Lung Cancer in Mice via Modulation of Proinflammatory Cytokines and Mitochondrial Enzymes
Lung cancer, one of the most often diagnosed malignancies, is the top cause of death in both men and women globally. In both developed and emerging...
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Expression Levels and Activity of Rat Liver Lactate Dehydrogenase Isoenzymes in Alloxan Diabetes
Abstract —A significant decrease in the activity of liver lactate dehydrogenase (LDH, EC 1.1.1.27) associated with a decrease in the expression of the...
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Engineered FGF19ΔKLB protects against intrahepatic cholestatic liver injury in ANIT-induced and Mdr2-/- mice model
BackgroundThe major safety concern of the clinical application of wild type FGF19 (FGF19 WT ) emerges given that its extended treatment causes...
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Identification of Diagnostic Biomarkers for Compensatory Liver Cirrhosis Based on Gut Microbiota and Urine Metabolomics Analyses
Liver cirrhosis is one of the most prevalent chronic liver disorders with high mortality. We aimed to explore changed gut microbiome and urine...
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Mesenchymal stem cell-derived exosomal miR-27b-3p alleviates liver fibrosis via downregulating YAP/LOXL2 pathway
Lysyl oxidase-like 2 (LOXL2) is an extracellular copper-dependent enzyme that plays a central role in fibrosis by catalyzing the crosslinking and...
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Huc-MSC-derived exosomes modified with the targeting peptide of aHSCs for liver fibrosis therapy
BackgroundEffective therapeutics to stop or reverse liver fibrosis have not emerged, because these potential agents cannot specifically target...
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Combined Effects of Fluoride and Arsenic on Mitochondrial Function in the Liver of Rat
Biochemical and/or molecular mechanisms of arsenic or fluoride toxicity in experimental animals have been widely investigated in the recent past....
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Dietary and genetic determinants of non-alcoholic fatty liver disease in coronary heart disease patients
PurposeA healthy diet reduces the risk of non-alcoholic fatty liver disease (NAFLD) in the general population, especially in individuals who are...
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Changes in the lipid profile of hamster liver after Schistosoma mansoni infection, characterized by mass spectrometry imaging and LC–MS/MS analysis
Schistosomiasis, caused by the human parasite Schistosoma mansoni , is one of the WHO-listed neglected tropical diseases (NTDs), and it has severe...
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Tricin-enriched Zizania latifolia ameliorates non-alcoholic fatty liver disease through AMPK-dependent pathways
This study aimed to identify and elucidate the mechanism underlying the protective effect of tricin-enriched Zizania latifolia (Z. latifolia ) extract...
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Metabolism of ADB-4en-PINACA in Zebrafish and Rat Liver Microsomes Determined by Liquid Chromatography–High Resolution Mass Spectrometry
AbstractMetabolic models can be useful for rapid identification of suitable analytical targets to aid in the detection of new psychoactive substances...
