Search
Search Results
-
Leveraging flow chemistry for the synthesis of trisubstituted isoxazoles
The synthesis of trisubstituted isoxazoles generally requires multiple individual chemical steps, making them amenable to improvements in efficiency...
-
Improved Synthesis of 5-(Chloromethyl)isoxazoles from Aldoximes and 2,3-Dichloropropene
AbstractCycloaddition of nitrile oxides generated in situ from aldoximes to 2,3-dichloroprop-1-ene in the oxidizing system Oxone ® –NaCl–Na 2 CO 3 in...
-
A metal-free approach for in situ regioselective synthesis of isoxazoles via 1,3 dipolar cycloaddition reaction of nitrile oxide with propargyl bromide
Herein, we report a multi-component reaction (MCRs) to synthesise a range of 3-phenyl-5-(bromomethyl)isoxazoles analogues using DMF/water mixture as...
-
The main directions and recent trends in the synthesis and use of isoxazoles
This review summarizes the main directions and recent trends in the synthesis of isoxazoles, and also provides examples of the use of isoxazoles as...
-
Pyrazoles, isoxazoles, and 1,2,3-triazoles as analogs of the natural cytostatic combretastatin A-4: efficient routes of synthesis, tubulin inhibition, and cytotoxicity
The review discusses the advantages and disadvantages of combretastatin A-4, presents the most effective methods for the synthesis of its...
-
Pyruvic acid-catalyzed one-pot three-component green synthesis of isoxazoles in aqueous medium: a comparable study of conventional heating versus ultra-sonication
A mild and efficient route for the one-pot synthesis of isoxazole derivatives has been developed using pyruvic acid as a catalyst under an aqueous...
-
One-Pot Synthesis of Trifluoromethyl-Substituted Imidazobenz[1,2-d]- and -[1,2-c]isoxazoles
AbstractSynthesis of regioisomeric 8-trifluoromethyl-4,5-dihydro-3 H -imidazo[4',5':5,6]benz[1,2 -d ]isoxazoles and 8-trifluoromethyl-4,5-dihydro-3 H -imidazo[4',5':3,4]benz[1,2...
-
Alkynes as Carbene Precursors for the Synthesis of Heterocycles
Catalytic metal carbene-involved transformations are considered as one of the most important aspects in homogeneous transition metal catalysis. The...
-
Alkaloids from Fungi
The prospection of unusual sources and undiscovered habitats is valuable in natural product research. Indeed, the fungi kingdom has received special...
-
Efficient Synthesis, Antioxidant Activity Evaluation, and Molecular Docking of Novel Isoxazole Derivatives
AbstractA series of previously unknown isoxazole-functionalized imidazopyridine derivatives were synthesized in a few steps, starting from...
-
Synthesis of 3-phenylbenzo[c]isoxazoles by thermocyclization of 2-azidobenzophenones
3-Phenylbenzo[ c ]isoxazoles were synthesized by non-catalytic thermolysis of 2-azidobenzophenones in dry xylene with quantitative yields. The trace...
-
Synthesis of five-membered heterocycles by [3+2] cycloaddition reactions of sulfur-containing 3,3,3-trifluoropropene derivatives
The present minireview provides a survey of literature reports on the application of 3,3,3-trifluoropropene derivatives bearing sulfur-containing...
-
Synthesis and Anticancer Activity of Some New 4-Azaindoleisoxazoles
AbstractHerein, synthesis of new 4-azaindole-1,2,4-isoxazoles by Cu(I)-catalyzed 1,3-dipolar cycloaddition reaction of...
-
Simple one-pot synthesis of 5-(chloromethyl)isoxazoles from aldoximes and 2,3-dichloro-1-propene
A one-pot synthesis of 3-substituted 5-chloromethylisoxazoles from available starting aldoximes and 2,3-dichloro-1-propene, serving both as a solvent...
-
Synthesis of novel isoxazole derivatives bearing kojic acid moiety and evaluation of their antimicrobial activity
A novel series of 3,5-disubstituted isoxazoles bearing kojic acid moiety were synthesized via Cu(I)-catalyzed 1,3-dipolar cycloaddition reaction of...
-
Synthesis and Antimicrobial Activity of 3-{2-[(1-Aryl-1H-1,2,3-triazol-4-yl)methoxy]-5-fluorophenyl}isoxazoles
A novel series 3-{2-[(1-aryl-1 H -1,2,3-triazol-4-yl)methoxy]-5-fluorophenyl}isoxazoles derivatives is synthesized from...
-
Pyrazoles and Isoxazoles Based Sulfanilamide and Phenazone as Antimicrobial Agents: Synthesis and Biological Activity
New pyrazole and pyridine derivatives have been synthesized from sulfanilamide and phenazone via diazotization and coupling with a wide range of α-CH...
-
An Efficient Synthesis and Antimicrobial Activity of 5-{2-[(1-Aryl-1H-1,2,3-triazol-4-yl)methoxy]-5-bromophenyl}isoxazoles
A novel series of 1,2,3-triazolyl isoxazole derivatives is synthesized from the corresponding propargylated isoxazoles and a number of aryl azides by...
-
Design, Ultrasonic-assisted Synthesis and Evaluation In vitro Antimicrobial Activity of Bis-isoxazole Derivatives Bearing Chloro-pyridinyl Group
A n ultrasonic-assisted synthesis of bis-isoxazole derivatives was developed. Eight...
-
Synthesis, Spectral Characterization, DFT and Docking Studies of 5-(4-chlorophenyl)-3-(coumarin-3-yl)-1H-Pyrazole and 5-(4-chlorophenyl)-3-(coumarin-3-yl)Isoxazole
AbstractFive membered hetrocyclic moieties have been proved to possess strong biological activities. The compounds...
