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Identification of Protein–Protein Interaction Associated Functions Based on Gene Ontology
Protein–protein interactions (PPIs) involve the physical or functional contact between two or more proteins. Generally, proteins that can interact...
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From Multiple Protein Docking to Protein–Protein Docking at Interactome Level
Molecular docking is used to anticipate the optimal orientation of a particular molecule to a target to form a stable complex. It makes predictions...
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Machine Learning Methods in Protein–Protein Docking
An exponential increase in the number of publications that address artificial intelligence (AI) usage in life sciences has been noticed in recent...
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Detecting PTP Protein–Protein Interactions by Fluorescent Immunoprecipitation Analysis (FIPA)
Identifying protein–protein interactions is crucial for revealing protein functions and characterizing cellular processes. Manipulating PPIs has...
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Computational Protein Binding
Why it is important to know this material? The computational approach to protein binding has become a crucial methodology in drug design and...
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Novel Bimolecular Fluorescence Complementation (BiFC) Assay for Visualization of the Protein–Protein Interactions and Cellular Protein Complex Localizations
Investigations of protein–protein interactions (PPIs) are of paramount importance for comprehending cellular processes within biological systems. The...
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Protein Structure Prediction and Analysis
Why it is important to know this material? Protein structure prediction is one of the hot topics of the modern computational biology. The...
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Protein-Ligand Interactions and Binding
Why it is important to know this material? Protein binding is implied in all biological mechanisms, and the definition of quantitative models and...
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Understanding the Structural Requirements of Peptide–Protein Interaction and Applications for Peptidomimetic Development
Protein–protein interaction is at the heart of most biological processes, and small peptides that bind to protein binding sites are resourceful tools...
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Challenges of Protein-Protein Docking of the Membrane Proteins
Despite the recent advances in the determination of high-resolution membrane protein (MP) structures, the structural and functional characterization...
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Complementary base pair interactions between different rare tautomers of the second-generation artificial genetic alphabets
The functionality of a semisynthetic DNA in the biological environment will depend on the base pair nature of its complementary base pairs. To...
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Live Cell Protein Imaging of Tandem Complemented-GFP11-Tagged Coiled-Coil Domain-Containing Protein-124 Identifies this Factor in G3BP1-Induced Stress-Granules
Coiled-coil domain-containing 124 protein is a multifunctional RNA-binding factor, and it was previously reported to interact with various...
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Chimeric Protein Switch Biosensors
Rapid detection of protein and small-molecule analytes is a valuable technique across multiple disciplines, but most in vitro testing of biological...
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The Genetic Algorithm Approach to Protein Structure Prediction
Predicting the three-dimensional structure of proteins from their linear sequence is one of the major challenges in modern biology. It is widely...
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Rationally Designed DNA-Based Scaffolds and Switching Probes for Protein Sensing
The detection of a protein analyte and use of this type of information for disease diagnosis and physiological monitoring requires methods with high...
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Approaches to Chemical Synthesis of Protein-Like Copolymers
Protein-like copolymers were first predicted by computer-aided biomimetic design. These copolymers consist of comonomer units of differing...
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Roles of inter- and intramolecular tryptophan interactions in membrane-active proteins revealed by racemic protein crystallography
Tryptophan is frequently found on the surface of membrane-associated proteins that interact with the lipid membrane. However, because of their...
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MD Simulation and Analysis of the Pair Correlation Functions, Self-Diffusion Coefficients and Orientational Correlation Times in Aqueous KCl Solutions at Different Temperatures and Concentrations
In this study, we investigate some structural and dynamical properties of aqueous KCl solutions at different temperatures and concentrations. We...
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Osteoclast Methods in Protein Phosphatase Research
Osteoclasts are specialized cells that degrade bone and are essential for bone formation and maintaining bone homeostasis. Excess or deficient...
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Protein Delivery and Mimicry
The multiple examples of the strategiesConjugation of the use of CPPs to shuttle the proteinsComplexation and protein mimicsProtein mimic and their...