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Corrosion Control (III): Corrosion Inhibitors
Corrosion inhibitors are effective in corrosion mitigation under CCUS conditions. Adding corrosion inhibitors is a relatively economical, effective,...
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CD73 Inhibitors as Antitumor Agents
5′-Ectonucleotidase (e5NT), a metalloenzyme incorporating two zinc ions in its structure, also known as CD73, hydrolyzes AMP to phosphate and...
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Overcoming Bacterial Resistance: Role of β-Lactamase Inhibitors
Resistance to modern antibiotics is currently a major health concern in treating infectious diseases. Abuse, overuse, and misuse of antibiotics in...
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QSAR and Molecular Modeling Studies of HIV Protease Inhibitors
Acquired immunodeficiency syndrome (AIDS) and its related disorders, caused by retrovirus human immunodeficiency virus (HIV) are a major health...
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Identification and Optimization of Protein Tyrosine Phosphatase Inhibitors Via Fragment Ligation
Phosphotyrosine biomimetics are starting points for potent inhibitors of protein tyrosine phosphatases (PTPs) and, thus, crucial for drug...
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Exploring bat-inspired cyclic tryptophan diketopiperazines as ABCB1 Inhibitors
Chemotherapy-induced drug resistance remains a major cause of cancer recurrence and patient mortality. ATP binding cassette subfamily B member 1...
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High-Throughput Discovery and Characterization of Covalent Inhibitors for Protein Tyrosine Phosphatases
Covalent inhibition has gained increasing interest in targeting the undruggable protein tyrosine phosphatases (PTPs). However, a systematic method...
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Proteinkinase Inhibitors
This book reviews the principles of design and examples of successful implementation of proteinkinase inhibitors (PKI), and offers a comprehensive...
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A Study of the Protective Properties of a Polysulfide Sealant Containing Corrosion Inhibitors
AbstractThe paper is devoted to the study of increasing protective properties of sealing materials by the introduction of corrosion inhibitors....
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QSAR Analysis of HDAC6 Inhibitors
AbstractHistone deacetylase inhibitors are the most important class of drugs for the treatment of oncology and other diseases due to their effect on...
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Antibody–peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins
Cysteine cathepsins are a family of proteases that are relevant therapeutic targets for the treatment of different cancers and other diseases....
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Constructing efficacy: a novel perspective on organic corrosion inhibitors and interfacial interactions
Notwithstanding diverse proposed methods for metal corrosion prevention, inhibitors are still the most popular. Undoubtedly, efficiency is the first...
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QSAR and Molecular Modeling Studiesof Factor Xa and Thrombin Inhibitors
Thrombotic disorders remain the major cause of death and disability in Western society. Many approaches to develop antithrombotic drugs that...
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Targeting the human gut microbiome with small-molecule inhibitors
The human gut microbiome is a complex microbial community that is strongly linked to both host health and disease. However, the detailed molecular...
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Protein Kinases and their Inhibitors Implications in Modulating Disease Progression
Protein phosphorylation plays an important role in cellular pathways, including cell cycle regulation, metabolism, differentiation and survival. The...
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Assays for the Screening and Characterization of Tau Aggregation Inhibitors
Aggregation of tau protein is a pathological hallmark of Alzheimer’s disease and other neurodegenerative tauopathies. Inhibition of tau aggregation...
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A compilation of Corrosion inhibitors in acidic environments: improvements and advancements from 2018–2023
Corrosion inhibition plays a pivotal role in safeguarding metal structures and equipment in diverse industrial sectors. This review paper examines...
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In Silico Discovery of Class IIb HDAC Inhibitors: The State of Art
HDAC6 and HDAC10 are class IIb HDAC isoenzymes. They have unique structural and physiological functions. They are key regulators of different...
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Meta-learning-based Inductive logistic matrix completion for prediction of kinase inhibitors
AbstractProtein kinases become an important source of potential drug targets. Develo** new, efficient, and safe small-molecule kinase inhibitors...
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HDAC2 SCAN: An Expert System for Virtual Screening of Histone Deacetylase 2 Inhibitors
AbstractHistone deacetylase 2 inhibitors (HDAC2) are developed as effective drugs for the treatment of various diseases. Using various types of...
