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Buttermilk: an important source of lipid soluble forms of choline that influences the immune system development in Sprague–Dawley rat offspring
PurposeTo determine the effect of feeding buttermilk-derived choline metabolites on the immune system development in Sprague–Dawley rat pups.
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Classes of Biologicals
Cytokines are polypeptides, proteins and glycoproteins, secreted by the cells of the immune system (IS) in very small quantities.
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PEGylation of Proteins as Tailored Chemistry for Optimized Bioconjugates
The high potential of peptides and proteins as therapeutic agents has not been fully exploited because of their common shortcomings: the only...
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Antiallergic Implications of Curcumin During COVID-19: Current Status and Perspectives
COVID-19 has impacted almost all nooks and corners of the globe. Initially, it was thought to cause respiratory ailments. However, the virions have...
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BCMA/CD47-directed universal CAR-T cells exhibit excellent antitumor activity in multiple myeloma
BackgroundBCMA-directed autologous chimeric antigen receptor T (CAR-T) cells have shown excellent clinical efficacy in relapsed or refractory...
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A Guide to the Quantitation of Protein Secretion Dynamics at the Single-Cell Level
Protein secretion is a key cellular functionality, particularly in immunology, where cells can display large heterogeneity in this crucial activity...
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Production and Evaluation of Nucleoside-Modified mRNA Vaccines for Infectious Diseases
Lipid nanoparticle (LNP)-encapsulated nucleoside-modified mRNA vaccines have demonstrated potency in multiple preclinical models against various...
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Cytokine Response to Nanoparticles Bearing Nucleic Acid Cargo
Non-viral gene delivery systems have proved to be promising for treatment of various cancers and other diseases. They are actively explored in...
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Malaria: Cellular Understanding of Disease
Malaria infection triggers immune responses, critical for limiting Plasmodium parasite infections and severity of disease manifestation. Albeit...
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Self-polymerized platinum (II)-Polydopamine nanomedicines for photo-chemotherapy of bladder Cancer favoring antitumor immune responses
Systemic administration of platinum-based drugs has obvious limitations in the treatment of advanced bladder cancer (BC) owing to lower tumor...
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Diazonium Salts and the Related Compounds for the Design of Biosensors
Aryldiazonium salt chemistryAryldiazonium salt chemistry, as a versatile surface decoration and functionalization method, has been intensively...
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Chemical generation of checkpoint inhibitory T cell engagers for the treatment of cancer
Bispecific T cell engagers (BiTEs), a subset of bispecific antibodies (bsAbs), can promote a targeted cancer cell’s death by bringing it close to a...
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RETRACTED ARTICLE: An overview on mRNA-based vaccines to prevent monkeypox infection
The human monkeypox virus (Mpox) is classified as a member of the Poxviridae family and belongs to the Orthopoxvirus genus. Mpox possesses...
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Chief Role of Neuroinflammation and Oxidative Stress in Brain Disorders
Neuroinflammation is the brain’s immune response against invading pathogens or any external or internal weird particles for their removal from the...
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Mucosal immunization with Lactiplantibacillus plantarum-displaying recombinant SARS-CoV-2 epitopes on the surface induces humoral and mucosal immune responses in mice
BackgroundThe use of probiotic lactic acid bacteria as a mucosal vaccine vector is considered a promising alternative compared to the use of other...
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Development of a human phage display-derived anti-PD-1 scFv antibody: an attractive tool for immune checkpoint therapy
BackgroundThe PD-1 checkpoint pathway plays a major role in tumor immune evasion and the development of the tumor microenvironment. Clinical studies...
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Die adaptive Abwehrreaktion: physiologisches und pathologisches Stimulationspotenzial von Lebensmittelkomponenten in der antigenspezifischen Immunantwort
Bei langwährender immunogener Stimulation wird eine antigenspezifische, adaptive Abwehrreaktion initiiert. Die etablierte Signallage der angeborenen...
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Biomimetic nanodrug blocks CD73 to inhibit adenosine and boosts antitumor immune response synergically with photothermal stimulation
Combination of tumor immunotherapy with photothermal therapy (PTT) is a feasible tactic to overcome the drawback of immunotherapy such as poor immune...
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Chemoproteomic development of SLC15A4 inhibitors with anti-inflammatory activity
SLC15A4 is an endolysosome-resident transporter linked with autoinflammation and autoimmunity. Specifically, SLC15A4 is critical for Toll-like...
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Therapeutic Antibodies : An Overview
Polyclonal immunoglobulin (Ig) preparations have been used for several decades for treatment of primary and secondary immunodeficiencies and for...