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RNA Structure Determination by High-Throughput Structural Analysis
RNA functions are closely linked with their structures. Therefore, elucidating the secondary structure of RNAs provides crucial information regarding...
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Generation of macro- and microplastic databases by high-throughput FTIR analysis with microplate readers
FTIR spectral identification is today’s gold standard analytical procedure for plastic pollution material characterization. High-throughput FTIR...
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Magnetic Microtweezers for High-Throughput Bioseparation in Sub-Nanoliter Droplets
Multiomics studies at single-cell level require small volume manipulation, high throughput analysis, and multiplexed detection, characteristics that...
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High-throughput droplet microfluidics screening and genome sequencing analysis for improved amylase-producing Aspergillus oryzae
BackgroundThe exceptional protein secretion capacity, intricate post-translational modification processes, and inherent safety features of A. oryzae ...
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High-Throughput Quantitative LC-MS/MS Analysis of Benzodiazepines in Human Urine
We hereby present a fast, high-throughput, and clinical LC-MS/MS assay for the simultaneous analysis of benzodiazepines in human urine. The assay is...
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Probing the chemical ‘reactome’ with high-throughput experimentation data
High-throughput experimentation (HTE) has the potential to improve our understanding of organic chemistry by systematically interrogating reactivity...
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Droplet microarray platforms for high-throughput drug screening
AbstractHigh-throughput screening platforms are fundamental for the rapid and efficient processing of large amounts of experimental data....
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High-Throughput Spectroscopic Analysis of mRNA Cap** Level
Eukaryotic mRNAs are characterized by terminal 5′ cap structures and 3′ polyadenylation sites, which are essential for posttranscriptional...
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High-throughput platforms for microextraction techniques
The proposal of high-throughput platforms in microextraction-based approaches is important to offer sustainable and efficient tools in analytical...
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High-Throughput Quantitative LC-MS/MS Analysis of Barbiturates in Human Urine
We hereby present a fast, high-throughput, and clinical LC-MS/MS assay for the simultaneous analysis of barbiturates in human urine. It is deployed...
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High-throughput process development from gene cloning to protein production
In the post-genomic era, the demand for faster and more efficient protein production has increased, both in public laboratories and industry. In...
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High-throughput analysis of lipidomic phenotypes of methicillin-resistant Staphylococcus aureus by coupling in situ 96-well cultivation and HILIC-ion mobility-mass spectrometry
Antimicrobial resistance is a major threat to human health as resistant pathogens spread globally, and the development of new antimicrobials is slow....
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Optical-Switch Raman Spectroscopy for High Throughput Screening
Although surface-enhanced Raman spectroscopy (SERS) is a powerful analytical technique with unbeaten sensitivity, the capabilities of SERS have been...
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High-throughput reprogramming of an NRPS condensation domain
Engineered biosynthetic assembly lines could revolutionize the sustainable production of bioactive natural product analogs. Although yeast display is...
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High-Throughput Arginylation Assay in Microplate Format
Here, we describe the biochemical assay for ATE1-mediated arginylation in microplate format, which can be applied to high-throughput screens for the...
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High-throughput phase elucidation of polycrystalline materials using serial rotation electron diffraction
Rapid phase elucidation of polycrystalline materials is essential for develo** new materials of chemical, pharmaceutical and industrial interest....
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High-Throughput Plasma Proteomic Profiling
Plasma and serum are rich sources of proteins that are commonly used for clinical proteome profiling and biomarkers discovery. However,...
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High-throughput and proteome-wide discovery of endogenous biomolecular condensates
Phase separation inside mammalian cells regulates the formation of the biomolecular condensates that are related to gene expression, signalling,...
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High Throughput Screening in Drug Discovery: Problems and Solutions
AbstractWorld-wide introduction of high throughput screening (HTS) methods in drug discovery research did not result in the increased number of novel...
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High-Throughput Discovery and Characterization of Covalent Inhibitors for Protein Tyrosine Phosphatases
Covalent inhibition has gained increasing interest in targeting the undruggable protein tyrosine phosphatases (PTPs). However, a systematic method...