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Quantitation of endogenous GnRH by validated nano-HPLC-HRMS method: a pilot study on ewe plasma
Gonadotropin-releasing hormone isoform I (GnRH), a neuro-deca-peptide, plays a fundamental role in development and maintenance of the reproductive...
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Optimized Identification of Triacylglycerols in Milk by HPLC-HRMS
This work has developed an optimized workflow for the targeted analysis of triacylglycerols (TAGs) in milk by liquid chromatography coupled with a...
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HPLC–UV Monitored Photostability-Test of LE404 and Identification of the Degradation Products via NMR and LC–HRMS
Dibenzoazecines are a new class of potential neuroleptics with a high potential for the treatment of schizophrenia. Initial stress tests indicated...
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Comparison of originator and biosimilar monoclonal antibodies using HRMS, Fc affinity chromatography, and 2D-HPLC
Due to the complex manufacturing process of therapeutic monoclonal antibodies, it is hardly possible to produce an identical copy of the original...
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Simultaneous determination of triazine herbicides and their metabolites in shellfish by HPLC-MS/MS combined with Q/E-Orbitrap HRMS
Triazine herbicides are used extensively in agriculture and aquaculture worldwide because of their broad effectiveness in weed control. However,...
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Identification, Isolation, and Structural Characterization of Novel Forced Degradation Products of Darunavir Using Advanced Analytical Techniques Like UPLC–MS, Prep-HPLC, HRMS, NMR, and FT-IR Spectroscopy
Since the stability of the pharmaceuticals plays a crucial role in efficacy and safety while using them in the treatment of disorders, the evaluation...
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Oligosaccharide Profile Analysis and Quality Control of Atractylodes macrocephala Koidz. Using HPLC-HRMS/MS and a Simple HPLC-ELSD Method
Oligosaccharides in Atractylodes macrocephala Koidz. (AMK) have a wide range of clinical effects, especially in terms of improving immunity. In this...
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Identification of Polyphenolic Compounds in Edible Wild Fruits Grown in the North-West of Italy by Means of HPLC-DAD-ESI HRMS
The popularity of edible wild fruits has increased in industrialized countries due to their composition and positive effects. The aim of this study...
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Experiments
All reactions were carried out under a positive atmosphere of Ar in dried glassware. Dehydrated solvents and materials were obtained from commercial...
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A new HPLC method with multiple detection systems for impurity analysis and discrimination of natural versus synthetic cannabidiol
Cannabidiol (CBD) is the main non-psychoactive phytocannabinoid derived from Cannabis sativa L. It is now an active pharmaceutical ingredient (API),...
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Comprehensive Stress Degradation Studies of Fipronil: Identification and Characterization of Major Degradation Products of Fipronil Including Their Degradation Pathways Using High Resolution-LCMS
Fipronil belongs to the phenylpyrazole family of insecticides and functions by interrupting the γ-aminobutyric acid system and chloride ion channels...
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Preparation and Characterization of Impurities of Teriflunomide—An Immunomodulatory Agent
AbstractTeriflunomide is an immunomodulatory agent used in the treatment of rheumatoid arthritis. Our present research work depicts the origin,...
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PFΔScreen — an open-source tool for automated PFAS feature prioritization in non-target HRMS data
Per- and polyfluoroalkyl substances (PFAS) are a huge group of anthropogenic chemicals with unique properties that are used in countless products and...
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Development of a Two-dimensional Liquid Chromatography High-Resolution Mass Spectrometry Method for the Characterization of Monoclonal Antibodies in Cell-Free Culture Supernatant via FcR Affinity Chromatography
A monoclonal antibody’s (mAb) glycosylation pattern has a significant impact on its binding affinity to the FcγRIIIa receptor and thus on...
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Determination of Methylphosphonic Acid and Alkyl Methylphosphonic Acid Esters in Soils by Liquid Chromatography–High-Resolution Mass Spectrometry
AbstractA method has been optimized for simultaneous extraction of ethyl methylphosphonic acid ester (EMPA), isopropyl methylphosphonic acid ester...
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Novel and facile process for the preparation of Brexpiprazole an antipsychotic drug
A novel and industrially viable process was developed to synthesize Brexpiprazole an antipsychotic drug. This process involves using 1,4-butanediol...
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Progress, applications, and challenges in high-throughput effect-directed analysis for toxicity driver identification — is it time for HT-EDA?
The rapid increase in the production and global use of chemicals and their mixtures has raised concerns about their potential impact on human and...
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Optimization of a Simple Analytical Workflow to Characterize the Phenolic Fraction from Grape Pomace
The recovery of polyphenols from grape pomace (GP) supports the promotion of sustainable bioeconomy. Accordingly, the development of pre-treatment...
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Identification and quantification of biosurfactants produced by the marine bacterium Alcanivorax borkumensis by hyphenated techniques
A novel biosurfactant was discovered to be synthesized by the marine bacterium Alcanivorax borkumensis in 1992. This bacterium is abundant in marine...
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Biodegradation of the Pesticides Bifenthrin and Fipronil by Bacillus Isolated from Orange Leaves
The pyrethroid bifenthrin and the phenylpyrazole fipronil are widely employed insecticides, and their extensive use became an environmental issue....
