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Glucan phosphorylase-catalyzed enzymatic synthesis of unnatural oligosaccharides and polysaccharides using nonnative substrates
Oligosaccharides and polysaccharides are comprised of complicated chemical structures owing to the structural variation of monosaccharide repeating...
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Rational construction of a high-quality and high-efficiency biosynthetic system and fermentation optimization for A82846B based on combinatorial strategies in Amycolatopsis orientalis
BackgroundOritavancin is a new generation of semi-synthetic glycopeptide antibiotics against Gram-positive bacteria, which served as the first and...
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Recent Advances in Rapid Screening Methods for Glycosyltransferases
Glycosyltransferases (GTs) are a diverse group of enzymes widely distributed in nature that catalyze the transfer of glycosyl moieties from activated...
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Chemoenzymatic synthesis of human natural killer-1-containing glycans and application as serum antibodies probes
Despite the versatility of enzyme-mediated oligosaccharide assembly, it has as a limitation that not all glycosyl transferases or glycan-modifying...
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Glycoconjugates
Carbohydrates covalently attached to proteins and lipids produce three types of glycoconjugates: proteoglycans, glycoproteins, and glycolipids....
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Calcium-Phosphate Combination Enhances Spinosad Production in Saccharopolyspora spinosa via Regulation of Fatty Acid Metabolism
Phosphate concentration above 10 mM reduces the production of many secondary metabolites; however, the phenomenon is not mechanistically understood...
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Enzymatically Modified Starch
Starch is a semicrystalline polymer that is abundantly present in nature as a source of energy storage. It has widespread applications in food and...
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Generation of Alkene Radical Cations by Heterolysis of β-Substituted Radicals: Mechanism, Stereochemistry, and Applications in Synthesis
The experimental basis for the formation of alkene radical cations by the heterolysis of alkyl radicals bearing leaving groups at the β position...
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A Glycosyltransferase from Arabidopsis thaliana Enables the Efficient Enzymatic Synthesis of Gastrodin
Gastrodin is an important plant-derived medicinal ingredient that has been used to treat various diseases. Biosynthesis is an effective strategy for...
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On the Prebiotic Synthesis of Nucleobases, Nucleotides, Oligonucleotides, Pre-RNA and Pre-DNA Molecules
All the strategies for the prebiotic syntheses of RNA and DNA assume the adequate availability of the presumptive precursors such as purine and...
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O-Glycoside Formation
When a monosaccharide (or sugar fragment of any size) is condensed with either an aliphatic or aromatic alcohol, or another sugar moiety through an...
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Integrated chemoenzymatic synthesis of a comprehensive sulfated ganglioside glycan library to decipher functional sulfoglycomics and sialoglycomics
Ganglioside glycans are ubiquitous and complex biomolecules that are involved in a wide range of biological functions and disease processes....
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Copolymers of Sodium Styrene Sulfonate and 2-Deoxy-2-methacrylamido-D-glucose with Antiviral Activity
AbstractThe radical copolymerization of sodium styrene sulfonate with vinyl saccharide 2-deoxy-2 - methacrylamido-D-glucose in water is studied. For...
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N-Glycosides
These type of glycosides are generated when a sugar component is attached to an aglycon, through a nitrogen atom, establishing as result a C-N-C...
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Glycosides, Synthesis and Characterization
MonosaccharidesMonosaccharides areGlycosides generally definedMonosaccharidesdefinition as aldosesAldoses and ketosesKetoses connected to a poly...
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Whole-cell bioconversion using non-Leloir transglycosylation reactions: a review
Microbial biocatalysts are evolving technological tools for glycosylation research in food, feed and pharmaceuticals. Advances in bioengineered...
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Immobilization of commercial acid phosphatases from wheat germ and potato onto ion exchangers
A very simple and fast immobilization technique based on ion exchange was investigated to improve the thermal stability of acid phosphatase from...
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Influence of Linkage Stereochemistry and Protecting Groups on Glycosidic Bond Stability of Sodium Cationized Glycosyl Phosphates
Energy-resolved collision-induced dissociation (ER-CID) experiments of sodium cationized glycosyl phosphate complexes, [GP x +Na] + , are performed to...
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Iron-Catalyzed Carbon–Carbon Coupling Reaction
Transition metal-catalyzed coupling reaction is one of the most effective strategies to construct carbon–carbon bonds. Because iron is Earth abundant...
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Small tools for sweet challenges: advances in microfluidic technologies for glycan synthesis
Glycans, including oligosaccharides and glycoconjugates, play an integral role in modulating the biological functions of macromolecules. Many...
