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Applications of Genome Editing in Extremophiles
The member of bacteria, archaea, and eukarya comes under the umbrella of extremophiles. Extremophiles can survive in the extremely harsh conditions...
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Chinese Hamster Ovary Cell Line Instability: Causes, Mitigation, and Prediction
Cell line instability is a common problem in biopharmaceutical manufacturing using Chinese hamster ovary (CHO) cells. Cell line instability, which...
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Gene Nanovector for Genome Therapy
Gene therapy is a potential approach to deal with complicated diseases that are now untreatable. A critical step in the effective gene therapy is the...
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Insights into genome plasticity and gene regulation in Orientia tsutsugamushi through genome-wide mining of microsatellite markers
Microsatellite markers are being used for molecular identification and characterization as well as estimation of evolution patterns due to their...
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The Causes for Genomic Instability and How to Try and Reduce Them Through Rational Design of Synthetic DNA
Genetic engineering has revolutionized our ability to manipulate DNA and engineer organisms for various applications. However, this approach can lead...
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Intraspecific variation in genome size in Artemisia argyi determined using flow cytometry and a genome survey
Different collections and accessions of Artemisia argyi (Chinese mugwort) harbour considerable diversity in morphology and bioactive compounds, but...
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Gene Nanovector for Genome Therapy
Gene therapy is a potential approach to deal with complicated diseases that are now untreatable. A critical step in the effective gene therapy is the...
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Applications of CPPs in Genome Editing of Plants
Cell penetrating peptides (CPPs) are short peptides that are able to translocate themselves and their cargo into cells. The progressive and...
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The Role of Whole-Genome Methods in the Industrial Production of Value-Added Compounds
The rate of microbial genome sequencing has accelerated with the introduction of high-throughput sequencing technologies and pertinent analytical...
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Minimal Cells and Genome Minimization: Top-Down and Bottom-Up Approaches to Construct Synthetic Cells
Bioproduction of high-value molecules has traditionally been carried out using engineered host cells. However, toxic molecules and membrane proteins...
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A Potential Risk Comprehensive Evaluation Model of Probiotic Species Based on Complete Genome Sequences
Probiotics are widely used in the fields of food and medicine. Some of these beneficial bacteria carry various antibiotic resistance genes and...
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Exosomes for CRISPR-Cas9 Delivery: The Cutting Edge in Genome Editing
Gene mutation correction was challenging until the discovery of clustered regularly interspaced short palindromic repeats (CRISPR) and...
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Generation of genome-edited dogs by somatic cell nuclear transfer
BackgroundCanine cloning technology based on somatic cell nuclear transfer (SCNT) combined with genome-editing tools such as CRISPR-Cas9 can be used...
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Biotinylated cyclic naphthalene diimide as a searching tool for G4 sites on the genome
A biotinyl cyclic naphthalene diimide (biotinyl cNDI) ( 1 ), in which biotin is introduced on the cyclic linker chain of cNDI with high G-quadruplex...
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LT-RPA: An Isothermal DNA Amplification Approach for Improved Microsatellite Genoty** and Microsatellite Instability Detection
Microsatellites are short tandem repeats of one to six nucleotides that are highly polymorphic and extensively used as genetic markers in numerous...
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Integrating pan-genome and reverse vaccinology to design multi-epitope vaccine against Herpes simplex virus type-1
Herpes simplex virus type-1 (HSV-1), the etiological agent of sporadic encephalitis and recurring oral (sometimes genital) infections in humans,...
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Unlocking the genome of the non-sourdough Kazachstania humilis MAW1: insights into inhibitory factors and phenotypic properties
BackgroundAscomycetous budding yeasts are ubiquitous environmental microorganisms important in food production and medicine. Due to recent intensive...
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Stimuli-responsive nanoformulations for CRISPR-Cas9 genome editing
The CRISPR-Cas9 technology has changed the landscape of genome editing and has demonstrated extraordinary potential for treating otherwise incurable...
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Cisgenesis and Genome Editing: A Combined Approach for Improved Plant Breeding
A more widespread implementation of novel biotechnologies in agriculture is quite interesting to characterize and explore potential plant genetic...
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Development and application of a rapid all-in-one plasmid CRISPR-Cas9 system for iterative genome editing in Bacillus subtilis
BackgroundBacillus subtilis , an important industrial microorganism, is commonly used in the production of industrial enzymes. Genome modification is...
