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Adsorption of alpha-synuclein and inhibition of fibril formation by nanocellulose and gold-coated-nanocellulose
Interfering with the aggregation of the protein alpha-synuclein (aSyn) has been a topic of research for > 25 years, as this protein is found in...
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Fibril formation and ordering of disordered FUS LC driven by hydrophobic interactions
Biomolecular condensates, protein-rich and dynamic membrane-less organelles, play critical roles in a range of subcellular processes, including...
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Neuroprotective effect of Bis(Indolyl)phenylmethane in Alzheimer’s disease rat model through inhibition of hen Lysozyme amyloid fibril-induced neurotoxicity
Amyloid aggregates are the hallmarks of several disorders, including Huntington's, Parkinson's and Alzheimer's diseases. Compounds that could inhibit...
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Measuring Antibody-Mediated Tau Fibril Uptake in Microglia by Flow Cytometry
Microglia are brain-resident phagocytic cells, considered to be the innate immune cells of the central nervous system. Microglia respond to both...
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A combination of surface-initiated controlled radical polymerization (SET-LRP) and click-chemistry for the chemical modification and fluorescent labeling of cellulose nanofibrils: STED super-resolution imaging of a single fibril and a single fibril embedded in a composite
A strategy is developed to modify cellulose nanofibril (CNF) surfaces with a combination of Cu 0 -mediated radical polymerization (SET-LRP) and Cu I -cata...
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Polymer materials as promoters/inhibitors of amyloid fibril formation
Polymers are omnipresent materials that are widely used in medicine, e.g., as construction materials for medical devices or as polymer nanoparticle...
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Structural analyses and force fields comparison for NACore (68–78) and SubNACore (69–77) fibril segments of Parkinson’s disease
The α-synuclein fibrils are a pathological hallmark of Parkinson’s disease (PD) and are abundant in the brains of PD patients. These amyloid fibrils...
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A rheological study of cationic micro- and nanofibrillated cellulose: quaternization reaction optimization and fibril characteristic effects
Driven by the demand for various cationic biopolymers in recent years, the quaternization of cellulose nanofibers was carefully investigated to have...
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Changes in the macro and nano-structure of paper during moisture cycling
Hygroexpansion, CP/MAS 13 C-NMR, WAXS and SAXS measurements were carried out on sheets made from four different commercial pulps of varying lignin...
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Structural mechanism for specific binding of chemical compounds to amyloid fibrils
Amyloid fibril is an important pharmaceutical target for diagnostic and therapeutic treatment of neurodegenerative diseases. However, rational design...
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Preparation and Fractionation of Heterogeneous Aβ42 Oligomers with Different Aggregation Properties
Deposition of amyloid-β (Aβ) aggregates in the form of amyloid plaques is a central feature of Alzheimer’s disease. The end products of Aβ...
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Dynamical VCD for Sol–Gel Transformation
This chapter describes the application of VCD to the dynamical processes of sol–gel transformation using a chiral low molecular weight gelator. The...
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Changes in the cellulose fiber wall supramolecular structure during the initial stages of chemical treatments of wood evaluated by NMR and X-ray scattering
The effect of initial stages of pul** of spruce, resembling prehydrolysis and alkaline cooking was studied using CP/MAS 13 C-NMR, X-ray scattering,...
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Monitoring Kinetics of pH-Dependent Aggregation and Disaggregation of the Pmel17 Repeat Domain
The premelanosomal protein (Pmel17) is a human functional amyloid that promotes pigmentation by serving as a scaffold for melanin polymerization....
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O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology
Amyloid-forming proteins such α-synuclein and tau, which are implicated in Alzheimer’s and Parkinson’s disease, can form different fibril structures...
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Pulp delignification and refining: impact on the supramolecular structure of softwood fibers
The effect on softwood fiber wall nanostructure of kraft cooking, oxygen delignification and refining was evaluated by X-ray scattering. A recently...
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Molecular Organization of Gel Fibrils as Revealed by VCD
This chapter is concerned with VCD application to gels. When a chiral low molecular weight gelator (LMWG) forms a gel from an organic solvent, it...
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Transformations of glucuronoxylan during acid sulphite pul** of eucalyptus dissolving pulp
Xylan is the main contaminant of hardwood sulphite dissolving pulp used for the production of regenerated cellulose. The amount of xylan in pulp...
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Mass photometric detection and quantification of nanoscale α-synuclein phase separation
Protein liquid–liquid phase separation can lead to disease-related amyloid fibril formation. The mechanisms of conversion of monomeric protein into...
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Monitoring fiber-like aggregation of collagen using gold nanoparticles as probes
Fiber-like aggregation is characteristic of the collagen molecule and appears in all descriptions of collagen from its molecular behavior to the...
