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PAFAH2 suppresses synchronized ferroptosis to ameliorate acute kidney injury
Synchronized ferroptosis contributes to nephron loss in acute kidney injury (AKI). However, the propagation signals and the underlying mechanisms of...
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Tumor-repopulating cells evade ferroptosis via PCK2-dependent phospholipid remodeling
Whether stem-cell-like cancer cells avert ferroptosis to mediate therapy resistance remains unclear. In this study, using a soft fibrin gel culture...
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Deciphering Ferroptosis: From Molecular Pathways to Machine Learning-Guided Therapeutic Innovation
Ferroptosis is a unique form of cell death reliant on iron and lipid peroxidation. It disrupts redox balance, causing cell death by damaging the...
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Dapagliflozin attenuates LPS-induced myocardial injury by reducing ferroptosis
Septic cardiomyopathy is a severe cardiovascular disease with a poor prognosis. Previous studies have reported the involvement of ferroptosis in the...
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CGI1746 targets σ1R to modulate ferroptosis through mitochondria-associated membranes
Ferroptosis is iron-dependent oxidative cell death. Labile iron and polyunsaturated fatty acid (PUFA)-containing lipids are two critical factors for...
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Irradiated microparticles suppress prostate cancer by tumor microenvironment reprogramming and ferroptosis
Immunogenic cell death (ICD) plays a crucial role in triggering the antitumor immune response in the tumor microenvironment (TME). Recently,...
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Mechanisms of Ferroptosis-Related Genes in Gallbladder Cancer Based on Bioinformatics Analysis
Gallbladder Cancer (GBC) is a lethal malignancy with limited treatment options and poor prognosis. Recent studies have emphasized the role of...
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Exploring the Role of Ferroptosis-Related Circular RNAs in Subarachnoid Hemorrhage
Subarachnoid hemorrhage (SAH) is a devastating cerebrovascular event associated with high mortality and significant morbidity. Recent studies have...
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Identification of essential sites of lipid peroxidation in ferroptosis
Ferroptosis, an iron-dependent form of cell death driven by lipid peroxidation, provides a potential treatment avenue for drug-resistant cancers and...
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The effect of TFAP2A/ANXA8 axis on ferroptosis of cervical squamous cell carcinoma (CESC) in vitro
Potential role and associated mechanisms of Annexin A8 (ANXA8), a member of the Annexins family, in cervical squamous cell carcinoma (CESC) are still...
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In situ and dynamic SERS monitoring of glutathione levels during cellular ferroptosis metabolism
Ferroptosis is a non-apoptotic cell death regulated by iron-dependent lipid peroxidation. Glutathione (GSH), a key antioxidant against oxidative...
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Anti-ferroptosis exosomes engineered for targeting M2 microglia to improve neurological function in ischemic stroke
BackgroundStroke is a devastating disease affecting populations worldwide and is the primary cause of long-term disability. The inflammatory storm...
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LncRNA-XIST Promotes Lung Adenocarcinoma Growth and Inhibits Ferroptosis by Regulating GPX4
This study aimed to explore the regulatory effects and molecular mechanisms of long non-coding RNA X-inactive-specific transcript (LncRNA-XIST) in...
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Mir22hg facilitates ferritinophagy-mediated ferroptosis in sepsis by recruiting the m6A reader YTHDC1 and enhancing Angptl4 mRNA stability
BackgroundFerritinophagy-mediated ferroptosis plays a crucial role in fighting pathogen aggression. The long non-coding RNA Mir22hg is involved in...
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Schizandrin A enhances the sensitivity of gastric cancer cells to 5-FU by promoting ferroptosis
Schizandrin A (Sch A) exert anticancer and multidrug resistance-reversing effects in a variety of tumors, but its effect on 5-fluorouracil (5-Fu) in...
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Silencing of METTL3 suppressed ferroptosis of myocardial cells by m6A modification of SLC7A11 in a YTHDF2 manner
Myocardial infarction (MI) is the main cause of heart failure (HF). N6-methyladenosine (m6A) methylation is associated with the progression of HF....
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Interference with MTHFD2 induces ferroptosis in ovarian cancer cells through ERK signaling to suppress tumor malignant progression
Ovarian cancer (OC) is a deadliest gynecological cancer with the highest mortality rate. Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), a...
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Self-assembled miR-134-5p inhibitor nanoparticles ameliorate experimental bronchopulmonary dysplasia (BPD) via suppressing ferroptosis
Bronchopulmonary dysplasia (BPD) is a chronic lung disease in premature infants with increased levels of reactive oxygen species (ROS) and...
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Platelet-Derived Microvesicles Mediate Cardiomyocyte Ferroptosis by Transferring ACSL1 During Acute Myocardial Infarction
Acute myocardial infarction (AMI) is one of the critical health conditions often caused by the rupture of unstable coronary artery plaque, triggering...
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METTL3-modified lncRNA DSCAM-AS1 promotes breast cancer progression through inhibiting ferroptosis
Numerous studies have indicated that N 6 -methyladenosine (m 6 A) and lncRNAs play pivotal roles in human cancer. However, the underlying functions and...
