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Specific features of epitope-MIPs and whole-protein MIPs as illustrated for AFP and RBD of SARS-CoV-2
Molecularly imprinted polymer (MIP) nanofilms for alpha-fetoprotein (AFP) and the receptor binding domain (RBD) of the spike protein of SARS-CoV-2...
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Immunoinformatics Protocol to Design Multi-Epitope Subunit Vaccines
With the development of scientific technologies, the accessibility of genomic data, computational tools, software, databases, and machine learning,...
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EPIPOX: A Resource Facilitating Epitope-Vaccine Design Against Human Pathogenic Orthopoxviruses
EPIPOX is a specialized online resource intended to facilitate the design of epitope-based vaccines against orthopoxviruses. EPIPOX is built upon a...
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Design of a novel multi-epitope vaccine against Marburg virus using immunoinformatics studies
Marburg virus (MARV) is a highly contagious and virulent agent belonging to Filoviridae family. MARV causes severe hemorrhagic fever in humans and...
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Preparation of C-Terminal Epitope Imprinted Particles for Recognition of Cytochrome c Assisted with γ-Cyclodextrin by Host-Guest Interaction
A kind of epitope surface imprinted particles was synthesized to selectively recognize cytochrome c (Cyt c) by a novel strategy assisted with...
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Searching Epitope-Based Vaccines Using Bioinformatics Studies
Epitope-based vaccines is one of the most recent methodologies applied in bioinformatics studies. This strategy consists of identifying regions of...
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Computer-Aided Multi-Epitope Based Vaccine Design Against Monkeypox Virus Surface Protein A30L: An Immunoinformatics Approach
Monkeypox, a viral zoonotic disease resembling smallpox, has emerged as a significant national epidemic primarily in Africa. Nevertheless, the recent...
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A Multi-epitope Vaccine Candidate Against Bolivian Hemorrhagic fever Caused by Machupo Virus
Bolivian hemorrhagic fever (BHF) caused by Machupo virus (MACV) is a New World arenavirus having a reported mortality rate of 25–35%. The BHF starts...
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CD4+ T Cell Epitope Identification from Complex Parasite Antigen Mixtures
Antigen complexity represents a major challenge for scoring CD4+ T cell immunogenicity, a key hallmark of immunity and with great potential to...
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Stable expression of HIV-1 MPER extended epitope on the surface of the recombinant probiotic bacteria Escherichia Coli Nissle 1917 using CRISPR/Cas9
BackgroundMucosal vaccines have the potential to induce protective immune responses at the sites of infection. Applying CRISPR/Cas9 editing, we aimed...
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Integrating pan-genome and reverse vaccinology to design multi-epitope vaccine against Herpes simplex virus type-1
Herpes simplex virus type-1 (HSV-1), the etiological agent of sporadic encephalitis and recurring oral (sometimes genital) infections in humans,...
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In Silico Analysis of a Candidate Multi-epitope Peptide Vaccine Against Human Brucellosis
Brucellosis is one of the neglected endemic zoonoses in the world. Vaccination appears to be a promising health strategy to prevent it. This study...
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An immunoinformatics and structural vaccinology approach to design a novel and potent multi-epitope base vaccine targeting Zika virus
Zika virus is an infectious virus, that belongs to Flaviviridae family, which is transferred to humans through mosquito vectors and severely...
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Bioinformatic Techniques for Vaccine Development: Epitope Prediction and Structural Vaccinology
Structural vaccinology involves characterizing the interactions between an antigen and antibodies or host immune receptors. Central to this is the...
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Designing multi-epitope based peptide vaccine targeting spike protein SARS-CoV-2 B1.1.529 (Omicron) variant using computational approaches
Millions of lives have been infected since the SARS-CoV-2 outbreak in 2019. The high human-to-human transmission rate has warranted a need for a...
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Computational Prediction of Trypanosoma cruzi Epitopes Toward the Generation of an Epitope-Based Vaccine Against Chagas Disease
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is considered a Neglected Tropical Disease. Limited investment is assigned to its...
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Design of an Epitope-Based Peptide Vaccine Against the Major Allergen Amb a 11 Using Immunoinformatic Approaches
Allergic diseases are a socially significant problem of global importance. The number of people suffering from pollen allergies has increased...
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Development of epitope-imprinted polydopamine magnetic nanoparticles for selective recognition of allergenic egg ovalbumin
In this study, epitope-imprinted polydopamine (PDA) magnetic nanoparticles (EIP-MNP) were developed for selective separation of allergenic ovalbumin...
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Computational design of a broad-spectrum multi-epitope vaccine candidate against seven strains of human coronaviruses
Spike (S) proteins are an attractive target as it mediates the binding of the SARS-CoV-2 to the host through ACE-2 receptors. We hypothesize that the...
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Tyrosine-Phosphorylated Peptide Imprinted Particles Prepared by Reversible Addition–Fragmentation Chain Transfer Polymerization and “Epitope” Strategy: Selective Recognition of Phosphorylated Angiotensin II
Phosphorylation is one of the most common post-translational modifications of proteins. Recognition of phosphorylated peptides with high selectivity...
