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Construction of cascade circuits for dynamic temporal regulation and its application to PHB production
BackgroundTo maximize the production capacity and yield of microbial cell factories, metabolic pathways are generally modified with dynamic...
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Dynamic feedback regulation for efficient membrane protein production using a small RNA-based genetic circuit in Escherichia coli
BackgroundMembrane proteins (MPs) are an important class of molecules with a wide array of cellular functions and are part of many metabolic...
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Metabolic engineering of Pichia pastoris for myo-inositol production by dynamic regulation of central metabolism
BackgroundThe methylotrophic budding yeast Pichia pastoris GS115 is a powerful expression system and hundreds of heterologous proteins have been...
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External stimulation-controlled dynamic DNA devices for biosensing and biomedical applications
DNA devices that can recognize molecular inputs and transform them into functional outputs in an autonomous manner have been actively pursued as...
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Environmental Regulation and Total Factor Carbon Productivity
This study investigates the relationship between environmental regulation and total factor carbon productivity in China’s industrial sectors. Using...
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Spatial–temporal regulation of fatty alcohol biosynthesis in yeast
BackgroundConstruction of efficient microbial cell factories is one of the core steps for establishing green bio-manufacturing processes. However,...
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Transcriptional regulation of living materials via extracellular electron transfer
Engineered living materials combine the advantages of biological and synthetic systems by leveraging genetic and metabolic programming to control...
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A helical fulcrum in eIF2B coordinates allosteric regulation of stress signaling
The integrated stress response (ISR) enables cells to survive a variety of acute stresses, but chronic activation of the ISR underlies age-related...
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Formation mechanism of dynamic liquid membranes for cellulose hydrolysis
Multi-phase system liquid membrane provides a promising pathway for cellulose efficient catalytic depolymerization to gain green biomass-based...
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pH-Responsive polyethyleneimine hydrogel based on dynamic covalent bonds
Smart hydrogels with excellent stimulus-responsiveness can be applied to a variety of fields. Herein, a new smart hydrogel with pH-responsive,...
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Design of stable covalent organic frameworks for transport regulation of mass and energy
This feature article discusses the design of stable covalent organic frameworks (COFs) for the transport regulation of protons, electrons, and...
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Construction of interfacial dynamic bonds for high performance lignin/polymer biocomposites
Lignin is the largest natural aromatic biopolymer, but usually treated as industrial biomass waste. The development of lignin/polymer biocomposites...
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Mass spectrometry coupling of chip-based supercritical fluid chromatography enabled by make-up flow-assisted backpressure regulation
This work introduces a novel microfluidic backpressure pressure control developed for chip-based supercritical fluid chromatography (chipSFC). The...
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Grid-Connected PV-Hydrogen Systems Providing Secondary Frequency Regulation: Modeling, Controller Design and Verification
The green hydrogen production system powered by renewable sources is expected to become an important way to decarbonize for the energy, chemical and...
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Transcription regulation strategies in methylotrophs: progress and challenges
As a promising industrial microorganism, methylotroph is capable of using methane or methanol as the sole carbon source natively, which has been...
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Development and characterization of a glycine biosensor system for fine-tuned metabolic regulation in Escherichia coli
BackgroundIn vivo biosensors have a wide range of applications, ranging from the detection of metabolites to the regulation of metabolic networks,...
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OGG1 at the Crossroads Between Repair and Transcriptional Regulation
Oxidative DNA modifications are a major challenge to genomic stability. One of the most abundant oxidative DNA base damage is the 8-oxoG, a mutagenic...
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Identification and Validation of Genes Exhibiting Dynamic Alterations in Response to Bleomycin-Induced Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) carries a high mortality rate and has a poor prognosis. The pathogenesis of pulmonary fibrosis (PF) is highly...
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OGG1 at the Crossroads Between Repair and Transcriptional Regulation
Oxidative DNA modifications are a major challenge to genomic stability. One of the most abundant oxidative DNA base damage is the 8-oxoG, a mutagenic...
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Insight into de-regulation of amino acid feedback inhibition: a focus on structure analysis method
Regulation of amino acid’s biosynthetic pathway is of significant importance to maintain homeostasis and cell functions. Amino acids regulate their...
