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Systematic Designing and Optimization of Polymeric Nanoparticles Using Central Composite Design: A Novel Approach for Nose-to-Brain Delivery of Donepezil Hydrochloride
The oral administration of donepezil hydrochloride has low brain targeting efficiency especially due to the presence of the blood–brain barrier...
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Donepezil oxidation: complementary chemical and spectroscopic exploration of products, mechanism and kinetics
Oxidation is a vital step of drug metabolism and hence a pharmaceutically relevant process. This study explores the potential of Donepezil, a widely...
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Donepezil and Embelin Loaded Nanostructured Lipid Carriers for Direct Brain Delivery as An Intervention for Alzheimer’s Disease: Formulation Design, Optimization and Evaluation
Donepezil hydrochloride (DPL) and Embelin (EMB) loaded Nanostructured Lipid Carriers (NLCs) have been developed and optimized to achieve optimal drug...
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Insights on the in-vitro binding interaction between donepezil and bovine serum albumin
In this work, the binding mechanism between donepezil (DNP) and bovine serum albumin (BSA) was established using several techniques, including...
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Multistep Continuous-Flow Synthesis of APIs Based on Aldol-Hydrogenation Strategy
Venlafaxine hydrochloride is a commonly used antidepressant agent. It inhibits the reuptake of serotonin and norepinephrine [Harvey et al. in Arch...
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In Vitro and In Vivo Evaluation of Oral Disintegrating Nanofiber and Thin-Film Contains Hyperbranched Chitosan/Donepezil for Active Drug Delivery
Hyperbranched chitosan ( HPCN ) has been synthesized from the polycondensation route and transformed into an oral thin film ( HCTF ) and nanofiber ( HCNF )...
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Novel quinolone-grafted chitosan derivatives with potential therapeutic properties: synthesis, characterization, in silico investigations, cholinesterase inhibitory potential, and antioxidant activity
Cholinesterase inhibitors are employed for treating different neuromuscular disorders that arise due to decreased levels of ACh in the cortical and...
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Phytochemical, Pharmacognostic, and In Vitro Acetylcholinesterase Inhibitory Activities of Cipadessa baccifera Leaves
Alzheimer’s disease is a degenerative neurological disorder with a limited number of viable therapy options. Cipadessa baccifera, also known as...
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An Acetylcholinesterase Sensor Based on a Pillar[6]arene–Silver Nanoparticle Composite for the Determination of Drugs for the Treatment of Alzheimer’s Disease
AbstractWe developed a voltammetric sensor based on a glassy carbon electrode modified with carbon black, pillar[6]arene, and silver nanoparticles...
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Challenges in Targeting Nasal Passage and Nose-to-Brain Delivery via Nanoemulsions
Nasal drug delivery has been considered an important approach for brain targeting since the last decade. The intranasal route has gained attention as...
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Michael addition reaction on 5,6-dimethoxy-2-methylene-2,3-dihydro-1H-inden-1-one: checking the products stability and evaluation of retro Michael reaction possibility
As for the importance of 1-indanone derivatives in this project, 5,6-dimethoxy-2-methylene-2,3-dihydro-1 H -inden-1-one has been synthesized by...
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Nasal Delivery of Micro and Nano Encapsulated Drugs
Drug encapsulation in nanoparticles and microparticles has been shown to be a promising application for nasal drug delivery. Drug encapsulation and...
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Neuroprotective effects of Fomes officinalis Ames polysaccharides on Aβ25–35-induced cytotoxicity in PC12 cells through suppression of mitochondria-mediated apoptotic pathway
Aggregation of Aβ is a pathological hallmark of Alzheimer’s disease (AD). The purpose of this study was to identify the protective roles of different...
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Smartphone-assisted hydrogel platform based on BSA-CeO2 nanoclusters for dual-mode determination of acetylcholinesterase and organophosphorus pesticides
A dual-mode sensor was developed for detecting acetylcholinesterase (AChE) and organophosphorus pesticides (OPs) via bifunctional BSA-CeO 2 ...
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Multifunctional Inhibitors of Cholinesterases for the Therapy of Alzheimer’s Disease (A Review)
AbstractAn analysis of the results of the author’s research on the development of multifunctional compounds based on the cholinesterase inhibitors...
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Novel Approaches in Nasal In Situ Gel Drug Delivery
The nasal cavity represents a suitable administration route both for local and systemic treatments. Conventional nasal formulations (liquid, solid,...
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Available Treatment Modules for Brain Disorders
Brain disorders (BD) linked to the brain as well as nerves found throughout the body are affecting millions of people yearly. Numerous factors such...
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New hybrids of tacrine and indomethacin as multifunctional acetylcholinesterase inhibitors
A new series of hybrid compounds were designed, consisting of anti-AChE and BuChE activity components with an anti-inflammatory component. A series...
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4-Oxobenzo[d]1,2,3-triazin-pyridinium-phenylacetamide derivatives as new anti-Alzheimer agents: design, synthesis, in vitro evaluation, molecular modeling, and molecular dynamic study
A new series of 4-oxobenzo[d]1,2,3-triazin-pyridinium-phenylacetamide hybrids 8a–p was designed, synthesized, and screened as the potential...
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New highly efficient multifunctional cholinesterase inhibitors based on the conjugation of amiridine and tacrine homolog
The synthesis of new hybrid compounds based on the domestic drug amiridine and a seven-membered cyclic homolog of tacrine combined by a...