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Strategies for Total and Diversity-Oriented Synthesis of Natural Product(-Like) Macrocycles
Numerous biologically active macrocycles, including antibiotic, antifungal, and antitumor compounds, have been isolated from natural sources. In...
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Diversity-oriented synthesis of glycomimetics
Glycomimetics are structural mimics of naturally occurring carbohydrates and represent important therapeutic leads in several disease treatments....
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Highly efficient and diversity-oriented solvent-free synthesis of biologically active fused heterocycles using glycerol-based sulfonic acid
The present article involves preparation of some novel fused quinazoline analogs by employing aromatic aldehydes, 1,3-cyclic diketones...
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Nonbiomimetic Total Synthesis of Polycyclic Alkaloids
In nonbiomimetic natural product synthesis, there are no restrictions on the design of synthetic routes; however, the feasibility of the planned...
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Controlled Synthesis of High Quality Semiconductor Nanocrystals
Synthesis of high quality semiconductor nanocrystals is discussed in this chapter. Although the focus is on the recent progress in synthesis of...
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Marine Natural Products from Pseudopterogorgia elisabethae: Structures, Biosynthesis, Pharmacology, and Total Synthesis
In the late 1990s, the Caribbean octocoral Pseudopterogorgia elisabethae became the target of extensive chemical investigations leading to the...
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Templation in Noncovalent Synthesis of Hydrogen-Bonded Rosettes
In this chapter, hydrogen-bonded assemblies based on the rosette motif are used to describe some examples of templation in noncovalent synthesis....
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Isocyanide-Based Multicomponent Reactions in Water: Advanced Green Tools for the Synthesis of Heterocyclic Compounds
Reaction rate acceleration using green methods is an intriguing area of research for chemists. In this regard, water as a “green solvent” plays a...
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Chemoenzymatic total synthesis of alchivemycin A
Alchivemycin A belongs to a unique class of polyketide natural products isolated from plant-derived actinomycete Streptomyces . It shows potent...
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Organic Synthesis
It is well known that cation–π interactions play an important role in the construction of three-dimensional protein structures and in the recognition...
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Chemoenzymatic synthesis of C14-functionalized steroids
C14-functionalized steroids display biological activity and have been used as medicines. The lack of synthetic methods to access C14-functionalized...
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AI for organic and polymer synthesis
Recent years have witnessed the transformative impact from the integration of artificial intelligence with organic and polymer synthesis. This...
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A divergent intermediate strategy yields biologically diverse pseudo-natural products
The efficient exploration of biologically relevant chemical space is essential for the discovery of bioactive compounds. A molecular design principle...
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Sequentially Palladium-Catalyzed Processes
Sequentially palladium-catalyzed reactions consist of combinations of identical, related, or significantly different palladium-catalyzed processes...
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Modular chemoenzymatic synthesis of ten fusicoccane diterpenoids
Fusicoccane diterpenoids display intriguing biological activities, including the ability to act as modulators of 14-3-3 protein–protein interactions....
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Catalytic enantioselective synthesis of boron-stereogenic BODIPYs
Boron dipyrromethenes (BODIPYs) are a class of tetracoordinate boron compounds that have attracted considerable interest in recent decades due to...
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Recent Advances on Solution-phase Synthesis of Metal Chalcohalide Nanocrystals
Chalcohalide nanocrystals have attracted significant attention as promising candidates for the fabrication of novel electronic and optoelectronic...
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Enzyme-Catalyzed Regio- and Enantioselective Ketone Reductions
In this chapter, examples are given of the application of highly reactive prochiral ketones as substrates for enzymatic reductions....
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Multicomponent synthesis of spiroannulated hybrid molecules with preferred substructures using indium triflate as a sustainable catalyst
An efficient and environmentally benign In(OTf) 3 catalysed multicomponent approach for the synthesis of spiroannulated pyridopyrimidines,...
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Hollow Multishelled Structure: Synthesis Chemistry and Application
Hollow multishelled structure (HoMS), a promising and complex multifunctional structural system, features at least two shells that are separated by...
