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Dihydroartemisinin-Chloro/Bromoisatin Hybrids: Design, Synthesis, and Anti-Breast Cancer Evaluation
AbstractTwelve dihydroartemisinin-chloro/bromoisatin hybrids were synthesized by combining dihydroartemisinin with chloro/bromoisatin and their in...
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Oil–water partition coefficient preparation and detection in the dihydroartemisinin self-emulsifying drug delivery system
BackgroundThe aim of the present study is to increase the solubility of dihydroartemisinin (DHA) using the self-emulsifying drug delivery system...
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Metal-organic framework-encapsulated dihydroartemisinin nanoparticles induces apoptotic cell death in ovarian cancer by blocking ROMO1-mediated ROS production
Dihydroartemisinin (DHA), a natural product derived from the herbal medicine Artemisia annua, is recently used as a novel anti-cancer agent. However,...
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A redox-responsive dihydroartemisinin dimeric nanoprodrug for enhanced antitumor activity
Redox-responsive drug delivery system emerges as a hopeful platform for tumor treatment. Dihydroartemisinin (DHA) has been investigated as an...
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A nanoreactor boosts chemodynamic therapy and ferroptosis for synergistic cancer therapy using molecular amplifier dihydroartemisinin
BackgroundChemodynamic therapy (CDT) relying on intracellular iron ions and H 2 O 2 is a promising therapeutic strategy due to its tumor selectivity,...
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Malaria – Current Treatment Options
Malaria diseases are caused by Plasmodium, either P. falciparum or non-P. falciparum requires antimalarial treatment guidelines. Artemisinin-based...
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Thermal stability and kinetic degradation study for dihydroartemisinin
Dihydroartemisinin (DHA), the hydrogenated derivative of the naturally originated sesquiterpene lactone artemisinin, is a well-known antimalarial...
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Optimization of HPLC–MS/MS method for determination of antimalarial adulterants in herbal products
The use of herbal products is booming all over the world because of being believed as safer than conventional drugs and free of side effects....
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Design, synthesis, and anti-breast-cancer activity evaluation of pyrrolo(pyrido)[2,3-d]pyrimidine derivatives
Ribociclib and palbociclib, two typical selective CDK4/6 inhibitors, which have been employed in clinic for the treatment of estrogen receptor...
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Polymeric Nanoparticles in Malaria
The major reason behind malaria becoming one of the most serious infectious diseases is the limitations of available antimalarial therapy. Drug...
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Antimalarial Drug Resistance: Trends, Mechanisms, and Strategies to Combat Antimalarial Resistance
Malaria is among the most prevalent parasite infections caused by Plasmodium genus. According to the most recent data available for the year 2020,...
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Nanosuspensions in Treatment of Malaria
Malaria is a disease caused by parasites spread through the bite of female Anopheles mosquitoes. Among the five parasite species, Plasmodium...
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pH-responsive nanocarriers for combined chemotherapies: a new approach with old materials
Ethyl cellulose (EC) is widely used in the pharmaceutical field as a polymeric excipient to fabricate sustained-release drug delivery systems. To...
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Clinical Trials in Malaria
Clinical trials are the final and most important phase in the process of new drug development against any disease or disorder. Due to the development...
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Recent Biotechnological Approaches for the Enhancement of Artemisinin Production from Cell Culture System of Artemisia annua L.: Medicinal Plant with Potent Antimalarial Properties
Artemisinin is the most potent antimalarial drug obtained from Artemisia annua. However, this metabolite found in low amounts in natural sources has...
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Solid Lipid Nanoparticles in Malaria
Malaria is a serious infectious disease that is caused due to Plasmodium parasites and is one of the major reasons for mortality due to infectious...
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Ion exchange resin-catalyzed synthesis of bridged tetraoxanes possessing in vitro cytotoxicity against HeLa cancer cells
Bridged 1,2,4,5-tetraoxanes were prepared using available acidic ion exchange resin with high yields despite the possibility of peroxide...
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Pectin nanoforms—a multifaceted polysaccharide and a propitious nanocarrier for medical ailments
Pectin is a natural anionic hetero-polysaccharide substantially found in fruits and cell wall of plants. Nanomaterials of natural polysaccharides are...
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Recent Innovations in the Strategies for the Functionalization of Chitosan, Pectin, Alginate, Hyaluronic Acid, Dextran and Inulin Biomaterials for Anticancer Applications-A Review
Polysaccharide biomaterials with carbohydrate backbones are currently the subject of material science and engineering research for anticancer...
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STUDIES ON SYNTHESES, CRYSTAL STRUCTURES, DFT CALCULATION AND ANTI-BREAST-CANCER ACTIVITIES OF ARTEMINSIN-PURINE HYBRIDS
AbstractA pair of C 9- C 10- trans - C 10-artemisinin-purine hybrids ( A and B ) were stereoselectively synthesized under a protonic acid condition, which...
