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Aquifer depletion exacerbates agricultural drought losses in the US High Plains
Aquifer depletion poses a major threat to the ability of farmers, food supply chains and rural economies globally to use groundwater as a means of...
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Development of finely tuned liposome nanoplatform for macrophage depletion
BackgroundImmunotherapy with clodronate-encapsulated liposomes, which induce macrophage depletion, has been studied extensively. However, previously...
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LncRNA BCRT1 depletion suppresses cervical cancer cell growth via sponging miR-432-5p/CCR7 axis
Breast cancer-related transcript 1 (BCRT1), a lncRNA that is overexpressed in several human cancers, facilitates the progression of breast cancer and...
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Depletion of abundant plasma proteins for extracellular vesicle proteome characterization: benefits and pitfalls
Blood extracellular vesicles (EVs) play essential roles in cell–cell communication and their molecular cargo is a promising source of disease...
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Dual depletion of myeloid-derived suppressor cells and tumor cells with self-assembled gemcitabine-celecoxib nano-twin drug for cancer chemoimmunotherapy
Myeloid-derived suppressor cells (MDSCs) have played a significant role in facilitating tumor immune escape and inducing an immunosuppressive tumor...
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Circ_0001944 depletion inhibits glycolysis and esophageal cancer progression by binding to miR-338-5p to reduce PDK1 expression
Circular RNA (circRNA) plays multiple roles in the development of esophageal cancer (EC). Herein, we investigate the function of circ_0001944 in EC...
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Hypertoxic self-assembled peptide with dual functions of glutathione depletion and biosynthesis inhibition for selective tumor ferroptosis and pyroptosis
Abundant glutathione (GSH) is a biological characteristic of lots of tumor cells. A growing number of studies are utilizing GSH depletion as an...
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Accelerating the discovery of alkyl halide-derived natural products using halide depletion
Even in the genomic era, microbial natural product discovery workflows can be laborious and limited in their ability to target molecules with...
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Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor
Creatine kinases (CKs) provide local ATP production in periods of elevated energetic demand, such as during rapid anabolism and growth. Thus,...
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Effects of Exposure Conditions on Antioxidant Depletion, Tensile Strength, and Creep Modulus of Corrugated HDPE Pipes Made With or Without Recycled Resins
The service lifetime of corrugated high-density polyethylene (HDPE) pipes used in transportation infrastructure applications has been the subject of...
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Environmental effects of stratospheric ozone depletion, UV radiation, and interactions with climate change: UNEP Environmental Effects Assessment Panel, Update 2021
The Environmental Effects Assessment Panel of the Montreal Protocol under the United Nations Environment Programme evaluates effects on the...
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Hemin-incorporating DNA nanozyme enabling catalytic oxygenation and GSH depletion for enhanced photodynamic therapy and synergistic tumor ferroptosis
Photodynamic therapy (PDT) has emerged as a promising tumor treatment method via light-triggered generation of reactive oxygen species (ROS) to kill...
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B-Cell Analysis for Monitoring Patients Undergoing B-Cell Depletion for the Treatment of Autoimmune Diseases
B-cell depleting therapy is increasingly used in the treatment of many distinct autoimmune diseases. This not only involves remission induction...
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3D printed hydrogel scaffolds combining glutathione depletion-induced ferroptosis and photothermia-augmented chemodynamic therapy for efficiently inhibiting postoperative tumor recurrence
Surgical resection to achieve tumor-free margins represents a difficult clinical scenario for patients with hepatocellular carcinoma. While...
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Novel Fast-switching LIGBT with Single-Step Low-k Dielectric Layer and Assistant-Depletion Trench
A novel low-loss and good-robustness silicon-on-insulator lateral insulated gate bipolar transistor (LIGBT) is proposed and investigated by...
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Tumor acidification and GSH depletion by bimetallic composite nanoparticles for enhanced chemodynamic therapy of TNBC
Chemodynamic therapy (CDT) based on intracellular Fenton reaction to produce highly cytotoxic reactive oxygen species (ROS) has played an essential...
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The response of aquatic ecosystems to the interactive effects of stratospheric ozone depletion, UV radiation, and climate change
Variations in stratospheric ozone and changes in the aquatic environment by climate change and human activity are modifying the exposure of aquatic...
