Search
Search Results
-
Conversion of senescent cartilage into a pro-chondrogenic microenvironment with antibody-functionalized copper sulfate nanoparticles for efficient osteoarthritis therapy
The development of osteoarthritis (OA) correlates with the expansion of senescent cells in cartilage, which contributes to an inflammatory...
-
Effect of Solanum lycopersicum and Citrus limon–Derived Exosome-Like Vesicles on Chondrogenic Differentiation of Adipose-Derived Stem Cells
Articular cartilage defect treatment is a very important problem because its therapeutic options are not successful enough. Due to the weak...
-
Precision 3D printed meniscus scaffolds to facilitate hMSCs proliferation and chondrogenic differentiation for tissue regeneration
BackgroundThe poor regenerative capability and structural complexity make the reconstruction of meniscus particularly challenging in clinic. 3D...
-
Guiding mesenchymal stem cells differentiation into chondrocytes using sulfated alginate/cold atmospheric plasma modified polycaprolactone nanofibrous scaffold
Using tissue engineering approaches is one of interesting strategies to repair cartilage injuries. This study reports the preparation of...
-
Effect assessment of a type of xeno-free and serum-free human adipose-derived mesenchymal stem cells culture medium by proliferation and differentiation capacities
Human mesenchymal stem cells (hMSCs) possess broad prospects in pre-clinical research. In vitro amplification of hMSCs requires appropriate medium to...
-
940 nm diode laser induced differentiation of human adipose derived stem cells to temporomandibular joint disc cells
BackgroundTemporomandibular disorder (TMD) refers to a group of disorders that affect temporomandibular joint (TMJ) and its associated muscles with...
-
Cartilage progenitor cells derived extracellular vesicles-based cell-free strategy for osteoarthritis treatment by efficient inflammation inhibition and extracellular matrix homeostasis restoration
Osteoarthritis (OA) is a common degenerative joint disease which currently lacks of effective agents. It is therefore urgent and necessary to seek an...
-
Immunomodulatory effect of human dedifferentiated fat cells: comparison with adipose-derived stem cells
Dedifferentiated fat cells (DFATs), which are originated by the dedifferentiation of adipocytes, display surface markers of mesenchymal stem cells...
-
Sodium Butyrate Induces Hepatic Differentiation of Mesenchymal Stem Cells in 3D Collagen Scaffolds
Stem cell-based therapy is considered an attractive tool to overcome the burden of liver diseases. However, efficient hepatic differentiation is...
-
Bioactive polypeptide hydrogels modified with RGD and N-cadherin mimetic peptide promote chondrogenic differentiation of bone marrow mesenchymal stem cells
Cell-material and cell-cell interactions represent two crucial aspects of the regulation of cell behavior. In the present study, poly (L-glutamic...
-
Bone Mesenchymal Stem Cells Inhibit Oxidative Stress–Induced Pyroptosis in Annulus Fibrosus Cells to Alleviate Intervertebral Disc Degeneration Based on Matric Hydrogels
Intervertebral disc degeneration (IVDD) is the primary cause of low back pain. Stem cell transplantation may be a possible approach to promote IVDD....
-
Apoptotic extracellular vesicles derived from hypoxia-preconditioned mesenchymal stem cells within a modified gelatine hydrogel promote osteochondral regeneration by enhancing stem cell activity and regulating immunity
Due to its unique structure, articular cartilage has limited abilities to undergo self-repair after injury. Additionally, the repair of articular...
-
Stem Cells and Proteomics in Biomaterials and Biomedical Applications
The constantly evolving field of regenerative medicine deals with replacing, repairing, or regenerating tissue by using multidisciplinary scientific...
-
Cerium oxide nanoparticles-carrying human umbilical cord mesenchymal stem cells counteract oxidative damage and facilitate tendon regeneration
BackgroundTendon injuries have a high incidence and limited treatment options. Stem cell transplantation is essential for several medical conditions...
-
Exploring the translational potential of PLGA nanoparticles for intra-articular rapamycin delivery in osteoarthritis therapy
Osteoarthritis (OA) is a prevalent joint disease that affects all the tissues within the joint and currently lacks disease-modifying treatments in...
-
The Evaluation of Meniscus Regenerative Effects of LIPUS-Induced CCN Proteins: Induction by LIPUS of CCN2 and Meniscus-Related Genes in Cultured Meniscus Cells and Meniscus Tissues
Menisci are a pair of crescent-shaped fibrocartilages and composed primarily of type I collagen. Inner region of the meniscus has similar...
-
Articular chondrocyte-derived extracellular vesicles promote cartilage differentiation of human umbilical cord mesenchymal stem cells by activation of autophagy
BackgroundUmbilical cord mesenchymal stem cell (HUCMSC)-based therapies were previously utilised for cartilage regeneration because of the...
-
Benchtop Isolation and Characterisation of Small Extracellular Vesicles from Human Mesenchymal Stem Cells
The objective of this study is to develop a simple protocol to isolate and characterise small extracellular vesicles (sEVs) from human umbilical...
-
Large-scale expansion of human umbilical cord-derived mesenchymal stem cells using PLGA@PLL scaffold
Mesenchymal stem cells (MSCs) are highly important in biomedicine and hold great potential in clinical treatment for various diseases. In recent...
-
Cell-Derived Matrix, Stem Cell Rejuvenation, and Tissue Regeneration
Extracellular matrix (ECM), the major component of tissue, plays a critical role in tissue engineering and regeneration. It is well-known that...