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Effect of membrane properties on the odor emanating from training aids for explosive-detecting canines
Canines are widely used for real-time detection of explosives and have proven to be on par with instrumental methods. Canines are thought to rely...
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Quantitative vapor delivery for improved canine threshold testing
The canine olfactory system is a highly efficient and intricate tool often exploited by humans for detection for its many attributes, including...
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A new workflow for the effective curation of membrane permeability data from open ADME information
Membrane permeability is an in vitro parameter that represents the apparent permeability (Papp) of a compound, and is a key absorption, distribution,...
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Paper spray ionization–high-resolution mass spectrometry (PSI-HRMS) of peroxide explosives in biological matrices
Mitigation of the peroxide explosive threat, specifically triacetone triperoxide (TATP) and hexamethylene triperoxide diamine (HMTD), is a priority...
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A review of proficiency exercises offered by the Veterinary Laboratory Investigation and Response Network (Vet-LIRN) and Moffett Proficiency Testing Laboratory from 2012 to 2018
The Food and Drug Administration’s Veterinary Laboratory Investigation and Response Network is comprised of more than 40 animal diagnostic...
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A least-squares-fitting procedure for an efficient preclinical ranking of passive transport across the blood–brain barrier endothelium
The treatment of various disorders of the central nervous system (CNS) is often impeded by the limited brain exposure of drugs, which is regulated by...
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Data-Driven and Artificial Intelligence Approaches for System-Wide Prediction of the Drugable Proteome to Drug Discovery in Farm Animals
A druggable proteome is of global interest for the drug development process. Growing livestock for food relies strongly on pharmacologically active...
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Wicking microfluidic approach to separate blood plasma from whole blood to facilitate downstream assays
Separation of blood plasma or serum from blood is essential for accurate analysis. Conventional blood separation requires instrumentation, reagents,...
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2D and 3D-QSAR Modeling of 1H‑Pyrazole Derivatives as EGFR Inhibitors: Molecular Docking, and Pharmacokinetic Profiling
In this research, quantitative structure activity relationship (QSAR) modeling, molecular docking, and pharmacokinetics profiling were utilized in...
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Development of CD163 receptor-based enzyme-linked immunosorbent assay for diagnosis of porcine reproductive and respiratory syndrome virus
Porcine reproductive and respiratory syndrome (PRRS) is an important economical disease in the global swine industry. The accurate detection of the...
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Companion animals get close to the toxic aspects of antropogenic world: cytotoxicity of phthalates and bisphenol A on dog testicular primary cells
Phthalates, which are among the most abundant plasticizers, have detrimental effects on the reproductive system. Similar to human, dogs are...
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FP-ADMET: a compendium of fingerprint-based ADMET prediction models
MotivationThe absorption, distribution, metabolism, excretion, and toxicity (ADMET) of drugs plays a key role in determining which among the...
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Diagnostics of lysosomal storage diseases by mass spectrometry: a review
Lysosomal storage disorders (LSD) are a group of over 70 rare inherited metabolic disorders that are caused mostly by the deficiency of specific...
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Structure-based virtual screening of mangiferin derivatives with antidiabetic action: a molecular docking and dynamics study and MPO-based drug-likeness approach
Extracts from Mangifera indica leaves and its main component, mangiferin, have proven antidiabetic activity. In this study, mangiferin and its...
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“Pandemics-on-a-Chip”: Organ-on-a-Chip Models for Studying Viral Infections
This chapter will address aspects of the biomanufacturing and application of the Organ-on-a-chip (OoC) platform for studying viral diseases since...
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In Vitro Models of CNS Barriers
In vitro models of the blood-brain barrier provide valuable mechanistic information and useful assay systems for drug discovery and delivery....
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Plasmid Vaccines and Therapeutics: From Design to Applications
In the late 1980s, Vical and collaborators discovered that the injection into tissues of unformulated plasmid encoding various proteins resulted in...
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Value Addition in Coconut Water
Health-conscious people, all over the world, focus their attention toward fitness and have shifted their preference from caffeinated and sugar-based...
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Smart Technologies in Livestock Farming
Smart technologies and its application have shown great promise for the modernization of extension services in both developed and develo**...
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3D-QSAR and Pharmacophore modeling of 3,5-disubstituted indole derivatives as Pim kinase inhibitors
Indole derivatives are reported in the literature for their excellent kinase inhibition activity, so understanding their structural requirement is...
