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3D stem-like spheroids-on-a-chip for personalized combinatorial drug testing in oral cancer
BackgroundFunctional drug testing (FDT) with patient-derived tumor cells in microfluidic devices is gaining popularity. However, the majority of...
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The m6A reader IGF2BP1 manipulates BUB1B expression to affect malignant behaviors, stem cell properties, and immune resistance of non-small-cell lung cancer stem cells
N6-methyladenosine (m6A) modification is the most common internal modification in eukaryotic mRNA and an important mechanism for post-transcriptional...
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Nucleoporin 93 Regulates Cancer Cell Growth and Stemness in Bladder Cancer via Wnt/β-Catenin Signaling
Bladder cancer (BLCA) is a prevalent cancer type with an unmet need for new therapeutic strategies. Nucleoporin 93 (Nup93) is implicated in the...
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Effect of Solanum lycopersicum and Citrus limon–Derived Exosome-Like Vesicles on Chondrogenic Differentiation of Adipose-Derived Stem Cells
Articular cartilage defect treatment is a very important problem because its therapeutic options are not successful enough. Due to the weak...
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Roles of lysophosphatidic acid (LPA) receptor-mediated signaling in cancer cell biology
Lysophosphatidic acid (LPA) is a simple lipid which is endogenously synthesized from lysophosphatidylcholine (LPC) by autotaxin (ATX). LPA mediates a...
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Selection of Cancer Stem Cell–Targeting Agents Using Bacteriophage Display
There is a growing need to develop tumor targeting agents for aggressive cancers. Aggressive cancers frequently relapse and are resistant to various...
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Chemoresistance Mechanisms in Non-Small Cell Lung Cancer—Opportunities for Drug Repurposing
Globally, lung cancer contributes significantly to the public health burden–associated mortality. As this form of cancer is insidious in nature,...
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Nanobiotechnology augmented cancer stem cell guided management of cancer: liquid-biopsy, imaging, and treatment
Cancer stem cells (CSCs) represent both a key driving force and therapeutic target of tumoral carcinogenesis, tumor evolution, progression, and...
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Single-Cell RNA Sequencing: Technological Progress and Biomedical Application in Cancer Research
Single-cell RNA-seq (scRNA-seq) is a revolutionary technology that allows for the genomic investigation of individual cells in a population, allowing...
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Investigation of In Vitro Anti-cancer and Apoptotic Potential of Onion-Derived Nanovesicles Against Prostate and Cervical Cancer Cell Lines
Plant-derived compounds have recently garnered significant interest in the field of medicine due to their rich repertoire of phytochemicals, which...
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Naturally Occurring Phytochemicals to Target Breast Cancer Cell Signaling
Almost 70% of clinically used antineoplastic drugs are originated from natural products such as plants, marine organism, and microorganisms and some...
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Biomimetic cell-derived nanocarriers in cancer research
Nanoparticles have now long demonstrated capabilities that make them attractive to use in biology and medicine. Some of them, such as lipid...
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MicroRNA-181b-5p Facilitates Thyroid Cancer Growth via Targeting Programmed Cell Death 4
To explore the potential mechanism of microRNA (miR)-181b-5p promoting the progression of thyroid cancer (TC) by targeting programmed cell death 4...
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Exosome-sheathed porous silica nanoparticle-mediated co-delivery of 3,3′-diindolylmethane and doxorubicin attenuates cancer stem cell-driven EMT in triple negative breast cancer
BackgroundTherapeutic management of locally advanced and metastatic triple negative breast cancer (TNBC) is often limited due to resistance to...
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Introduction to Animal Cell Culture
Animal cell culture has marked a significant revolution in science, allowing different fields to benefit from its use. The aim of this chapter is to...
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Autophagy: a necessary evil in cancer and inflammation
Autophagy, a highly regulated cellular process, assumes a dual role in the context of cancer. On the one hand, it functions as a crucial homeostatic...
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Dual-drug-loaded MSCs-derived exosomal vesicles inhibit endometrial cancer cell proliferation by promoting apoptosis through the migration and invasion of Rac1/NF-κB/MMP2 signalling pathway
AbstractEndometrial carcinoma affects the uterine lining. Endogenous activity, intrinsic targeting, and ability to engage with a host defence system...
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Facile Green Synthesis of Silver Nanoparticles Using Passiflora edulis and Its Efficacy Against the Breast Cancer Cell Line
The field of plant-mediated nanoparticle synthesis is growing rapidly worldwide. It has been revealed that plant biomolecules are useful in the...
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Excitation Frequency Effect on Breast Cancer Cell Death by Atmospheric Pressure Cold Plasma
The tuning capacity of a novel excitation frequency controlled cold atmospheric pressure plasma jet in terms of reactive species density and its...
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Protein-Based Materials as Cancer In Vitro Models
The extracellular matrix (ECM) plays an active role in tumor progression. Increasing evidence points out a permissive tumor microenvironment that...