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Effects of the Ethanol and Ethyl Acetate Extracts of Terminalia chebula Retz. on Proliferation, Migration, and HIF-1α and CXCR-4 Expression in MCF-7 Cells: an In Vitro Study
Over recent years, much attention has been devoted to the field of screening natural products and/or their novel structures because of reversing...
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G Protein-Coupled Receptors
G protein-coupled receptors (GPCRs) are important drug targets for FDA-approved drugs. Understanding the biology, structure, and pharmacology of...
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Antiallergic Implications of Curcumin During COVID-19: Current Status and Perspectives
COVID-19 has impacted almost all nooks and corners of the globe. Initially, it was thought to cause respiratory ailments. However, the virions have...
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Die adaptive Abwehrreaktion: physiologisches und pathologisches Stimulationspotenzial von Lebensmittelkomponenten in der antigenspezifischen Immunantwort
Bei langwährender immunogener Stimulation wird eine antigenspezifische, adaptive Abwehrreaktion initiiert. Die etablierte Signallage der angeborenen...
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Diagnostic Efficiency of Determining CXCR1, CXCR2 and Hyaluronic Acid in Blood of Patients with Non-Small Cell Lung Cancer
Abstract —Non-small cell lung cancer (NSCLC) accounts for most cases of lung cancer. Histologically, it is subdivided into two histological subtypes:...
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Computational design of anti-cancer peptides tailored to target specific tumor markers
Anti-cancer peptides (ACPs) are short peptides known for their ability to inhibit tumor cell proliferation, migration, and the formation of tumor...
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Vanadium complexes: potential candidates for therapeutic applications
Transition metal with variable oxidation states has always been a point of attraction since many decades for scientists with special focus in the...
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Macrophage biomimetic nanoparticle-targeted functional extracellular vesicle micro-RNAs revealed via multiomics analysis alleviate sepsis-induced acute lung injury
Patients who suffer from sepsis typically experience acute lung injury (ALI). Extracellular vesicles (EVs) contain miRNAs, which are potentially...
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RNA Sequencing and Bioinformatics Analysis Reveals the Downregulation of DNA Replication Genes by Morindone in Colorectal Cancer Cells
Morindone, a natural anthraquinone compound, has been reported to have significant pharmacological properties in different cancers. However, its...
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Will CRISPR-Cas9 Have Cards to Play Against Cancer? An Update on its Applications
Genome editing employs targeted nucleases as powerful tools to precisely alter the genome of target cells and regulate functional genes. Various...
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The Highly Expressed IFIT1 in Nasopharyngeal Carcinoma Enhances Proliferation, Migration, and Invasion of Nasopharyngeal Carcinoma Cells
In this study, we aimed to identify potential targets modulating the progression of nasopharyngeal carcinoma (NPC) using integrated bioinformatics...
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Entrectinib a Plausible Inhibitor for Osteopontin (SPP1) in Cervical Cancer—Integrated Bioinformatic Approach
AbstractCervical cancer is one of the major causes of death in women, especially in develo** countries bearing more than a quarter of the global...
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Immune modulating nanoparticles for the treatment of ocular diseases
Ocular diseases are increasingly influencing people’s quality of life. Complicated inflammatory mechanisms involved in the pathogenic process of...
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Die Immunbarriere: Einfluss von Lebensmittelkomponenten auf die Darmbarriere
Die Haut und Schleimhäute des Körpers bilden das erste Abwehrelement des Immunsystems. Ein- bis mehrschichtiges epitheliales Abschlussgewebe formen...
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Modulation of the Immune System Promotes Tissue Regeneration
The immune system plays an essential role in the angiogenesis, repair, and regeneration of damaged tissues. Therefore, the design of scaffolds that...
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Hesperidin: Advances on Resources, Biosynthesis Pathway, Bioavailability, Bioactivity, and Pharmacology
The dietary flavonoid hesperidin is the most vital phytochemical in orange peel and other citrus species and is of great general interest due to...
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Application of antigen presenting cell-targeted nanovaccine delivery system in rhabdovirus disease prophylactics using fish as a model organism
BackgroundTargeted delivery of virus-associated antigens to professional antigen-presenting cells (APCs) is considered as an efficient strategy to...
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Novel drug delivery systems targeting oxidative stress in chronic obstructive pulmonary disease: a review
Oxidative stress is significantly involved in the pathogenesis and progression of chronic obstructive pulmonary disease (COPD). Combining antioxidant...
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Future Trends and Innovation in Nano Drug Delivery for Cancer Therapy, Application of siRNA (Nanoparticle-Based RNA) Therapy, Ultrasound Linked Nano-Cancer Therapeutics, and Application of Exosomes-Based Cancer Therapy
The chapter discusses the roles of nanoparticles and hybrid nanoparticles for drug delivery in chemotherapy, targeted therapy, and immunotherapy and...
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Homocysteine-induced decrease in HUVEC cells’ resistance to oxidative stress is mediated by Akt-dependent changes in iron metabolism
PurposeHyperhomocysteinemia is an independent risk factor for cardiovascular diseases and also promotes neuronal death in various neurodegenerative...
