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A bifunctional bortezomib-loaded porous nano-hydroxyapatite/alginate scaffold for simultaneous tumor inhibition and bone regeneration
Treatments of osteolytic lesions due to malignant metastasis remain one of the major clinical challenges. The residual tumor cells after surgical...
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Development and Validation of Highly Sensitive LC–ESI-MS/MS Method for Bortezomib and Its Applications for Plasma Levels and Drug Content of Branded and Generic Formulations in India
In the present study, a highly sensitive and reproducible bio-analytical method was developed using LC–ESI-MS/MS to assess the lower plasma levels of...
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Development of a novel indirubin derivative with enhanced anticancer properties: synthesis, in Vitro, and in Vivo evaluation
The indirubin ( 2 ) derivative undergoes condensation with hydroxylamine hydrochloride, resulting in the formation of a novel indirubin derivative ( 3 )...
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Preparation, characterization and in vitro–in vivo evaluation of bortezomib supermolecular aggregation nanovehicles
BackgroundsIntolerable toxicity and unsatisfactory therapeutic effects are still big problems retarding the use of chemotherapy against cancer....
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Novel block glycopolymers prepared as delivery nanocarriers for controlled release of bortezomib
To explore block glycopolymers as novel polymeric delivery nanocarriers for anticancer drug bortezomib (BTZ), three types of block glycopolymers,...
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Alginate in Cancer Therapy
According to WHO World Health Organization, Cancer https://www.who.int/news-room/fact-sheets/detail/cancer...
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Methods for Molecular Imaging, Detection and Visualization of CPPs
In this chapter, the most frequentlyVisualization used methods for studies of CPP internalization, mechanismsMechanism and localization are...
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Targeted degradation via direct 26S proteasome recruitment
Engineered destruction of target proteins by recruitment to the cell’s degradation machinery has emerged as a promising strategy in drug discovery....
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Poly(2-oxazoline)s: synthesis and biomedical applications
With the advancement of medical technology, the previous biomedical material platforms have been unable to meet the increasingly diverse application...
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Effects of curcumin-/boron-based compound complexation on antioxidant and antiproliferation activity
Simple and reproducible formulation strategies are needed to improve the bio-availability of curcumin. In this study, curcumin was successfully...
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A compendium of kinetic modulatory profiles identifies ferroptosis regulators
Cell death can be executed by regulated apoptotic and nonapoptotic pathways, including the iron-dependent process of ferroptosis. Small molecules are...
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Recent advancements of electrospun nanofibers for cancer therapy
Nanotechnology is a rapidly increasing scientific field due to its immense potential for develo** new materials with exceptional...
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Harnessing the anti-cancer natural product nimbolide for targeted protein degradation
Nimbolide, a terpenoid natural product derived from the Neem tree, impairs cancer pathogenicity; however, the direct targets and mechanisms by which...
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Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11
The proteasome is a vital cellular machine that maintains protein homeostasis, which is of particular importance in multiple myeloma and possibly...
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Stimuli-Responsive Mussel-Inspired Polydopamine Material
The first material-independent surface chemistry called polydopamine coating was introduced in Chap. 14...
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Targeted genome editing in acute lymphoblastic leukemia: a review
BackgroundGenome editing technologies offers new opportunities for tackling diseases such as acute lymphoblastic leukemia (ALL) that have been beyond...
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Antioxidant micelles for bortezomib delivery
Reactive oxygen species (ROS) serve important regulatory roles in cellular processes. However, elevated ROS levels have been linked with several...
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Discovery of novel covalent proteasome inhibitors through a combination of pharmacophore screening, covalent docking, and molecular dynamics simulations
The ubiquitin–proteasome pathway plays a pivotal role in the regulation of cellular protein processing and degradation. Proteasome inhibitors (PIs)...
