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Sample preparation for fatty acid analysis in biological samples with mass spectrometry-based strategies
Fatty acids (FAs) have attracted many interests for their pivotal roles in many biological processes. Imbalance of FAs is related to a variety of...
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Sample size calculation in biomedical, clinical and biological sciences research
Sample size determination is a critical aspect of biomedical research, as it dictates the number of samples needed for a successful experiment that...
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Sample preparation techniques for extraction of vitamin D metabolites from non-conventional biological sample matrices prior to LC–MS/MS analysis
The determination of vitamin D metabolites as status marker or for diagnostic purposes is almost entirely conducted from blood serum or plasma. Other...
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Advances in sample preparation and HPLC–MS/MS methods for determining amyloid-β peptide in biological samples: a review
Alzheimer’s disease (AD), a neurological disorder, is a major public health concern and the most common form of dementia. Its typical symptoms...
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Quantitation and speciation of inorganic arsenic in a biological sample by capillary ion chromatography combined with inductively coupled plasma mass spectrometry
The toxicity and biological activity of arsenic depend on its chemical form. In particular, inorganic arsenics are more toxic than organic ones....
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Sampling and Sample Preparation
Food quality is monitored at various processing stages but 100% inspection is rarely possible or even desirable. To ensure a representative sample of...
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Dried Samples of Biological Fluids on Porous Membranes as a Promising Sample Preparation Method for Biomedical and Veterinary Diagnostics
AbstractThe sample preparation method for liquid biosamples dried on a carrier (dried blood spot technology) has been increasingly used in various...
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Preparation of complex biological sample-compatible “turn-on”-type ratiometric fluorescent molecularly imprinted polymer microspheres via one-pot surface-initiated ATRP
The efficient preparation of ratiometric fluorescent molecularly imprinted polymer (MIP) microspheres that can directly and selectively optosense a...
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Measurement of Ice Nucleation Activity of Biological Samples
Experimentation with ice-nucleating biomolecules is needed to advance the fundamental understanding of biotic heterogeneous ice nucleation. Standard...
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Microscopic VCD Scanning of Biological Organs
This chapter describes the prompt acquisition of two-dimensional VCD signals on a thin film. For this purpose, the system (named MultiD-VCD) using...
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Sample Preparation in Microbial Metabolomics: Advances and Challenges
Microbial metabolomics has gained significant interest as it reflects the physiological state of microorganisms. Due to the great variability of...
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Evaluation of Trace Elements in Marine Biological Tissues by Graphite Furnace Atomic Absorption Spectrometry After Sample Treatment with Formic Acid
In this work, formic acid was used as an extracting solvent in a fast and accurate procedure for Cd and Pb determination in biological tissue by...
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Biological Agents
The chapter on biological agents contains the classification of pathogens and toxins and describes also the most important bacteria, viruses and...
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Sample Preparation for Metabolite Detection in Mass Spectrometry Imaging
Metabolites reflect the biological state of cells and tissue, and metabolomics is therefore a field of high interest both to understand normal...
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Sampling and Sample Preparation in Bioanalysis
Many types of samples from the biosphere can be analyzed: a biofluid, an organ, a tissue, a cell, or even a virus, i.e., a viral nanoparticle. There...
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Conventional Methods of Sample Preparation for Quality Control of Chinese Medicines
Sample preparation is an important and time-consuming step in quality control of herbal medicine. Due to the state of most solid samples, their...
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Plastic probe electrospray ionization mass spectrometry developed for rapid fingerprint profile of biological samples without pretreatment
A triangular-shaped flat plastic substrate probe was prepared for direct electrospray ionization mass spectrometry (ESI–MS) for analysis of untreated...
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A device for rapid calorimetric measurements on small biological tissue samples
A new calorimetric technique is described that allows high-throughput heat production rate measurements on small biological tissue samples. The...
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Robust Surfactant-Assisted One-Pot Sample Preparation for Label-Free Single-Cell and Nanoscale Proteomics
With advanced mass spectrometry (MS)-based proteomics, genome-scale proteome coverage can be achieved from bulk cells. However, such bulk measurement...
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Indispensable Potency (Biological Activity)
The measurement of potency (strength) is a regulatory requirement for all pharmaceuticals. For chemical drugs, the potency is determined by measuring...