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Synthesis of Carbolines Possessing Antitumor Activity
Synthetic approaches to a number of carboline derivatives having antitumor activity are described. Representative examples of molecules with...
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Pyrrole Natural Products with Antitumor Properties
This review examines the antitumor activity and synthetic strategies for pyrrole-containing natural products possessing the oxygenated...
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CD73 Inhibitors as Antitumor Agents
5′-Ectonucleotidase (e5NT), a metalloenzyme incorporating two zinc ions in its structure, also known as CD73, hydrolyzes AMP to phosphate and...
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Synthesis and pharmacological evaluation of polyamine-diarylidenyl piperidone derivatives as potent antitumor agents
Two polyamine-diarylidenyl piperidone (DAP) derivatives, dimer polyamine-H-4073 and tetrameric polyamine-H-4073, were designed and synthesized as...
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Recent advances in melittin-based nanoparticles for antitumor treatment: from mechanisms to targeted delivery strategies
As a naturally occurring cytolytic peptide, melittin (MLT) not only exhibits a potent direct tumor cell-killing effect but also possesses various...
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Copper(ii) Complexes Based on 2,2’-Bipyridine and 1,10-Phenanthroline as Potential Objects for Develo** Antitumor Drugs
AbstractThe review is devoted to copper coordination compounds based on 2,2′-bipyridine / 1,10-phenanthroline and diverse N-, O-, S-donor ligands...
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TROP2-directed nanobody-drug conjugate elicited potent antitumor effect in pancreatic cancer
BackgroundPancreatic cancer is a highly aggressive malignancy with limited treatment options and a poor prognosis. Trophoblast cell surface antigen 2...
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BCMA/CD47-directed universal CAR-T cells exhibit excellent antitumor activity in multiple myeloma
BackgroundBCMA-directed autologous chimeric antigen receptor T (CAR-T) cells have shown excellent clinical efficacy in relapsed or refractory...
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Metal ions and nanometallic materials in antitumor immunity: Function, application, and perspective
The slightest change in the extra/intracellular concentration of metal ions results in amplified effects by signaling cascades that regulate both...
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Potential antitumor activity of garlic against colorectal cancer: focus on the molecular mechanisms of action
PurposeThe aim of this review is to highlight the potential of garlic phytoconstituents as antitumor agents in colorectal cancer management based on...
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Development and Characterization of Graphene Oxide-Locust Bean Gum-Zinc Oxide (GO-LBG-ZnO) Nanohybrid as an Efficient and Novel Antitumor Agent against Hepatocarcinoma Cells
The main goal of this study was to introduce a nanohybrid based on graphene oxide and zinc oxide with strong antitumor activity for the treatment of...
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MiR-214 promotes the antitumor effect of NK cells in colorectal cancer liver metastasis through USP27X/Bim
Colorectal cancer (CRC) is a common tumor type, and liver metastasis reduces the long-term survival in CRC patients. Natural killer (NK) cells play...
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Enhanced Antitumor Effect of the Combination of Bacille Calmette-Guérin and an Immune Checkpoint Inhibitor in Bladder Cancer-On-a-Chip
We upgraded preexisting bladder cancer-on-a-chip (BCOC) by adding T cells and evaluated the antitumor effect of a combination of intravesical Bacille...
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Synthesis of derivatives of 6-aryl-2,2′-bipyridine complexes with PtII as potential antitumor agents
New Pt II complexes of aryl- and diaryl-2,2′-bipyridines were prepared using the Kröhnke method for the further synthesis of pyridine derivatives....
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Chemical Biology Studies on Aplyronine A, A PPI-Inducing Antitumor Macrolide from Sea Hare
The antitumor macrolide aplyronine A (ApA) disturbs microtubule (MT) dynamics by inducing the protein–protein interaction (PPI) between actin and...
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A mitochondria-anchored supramolecular photosensitizer as a pyroptosis inducer for potent photodynamic therapy and enhanced antitumor immunity
BackgroundThe discovery of a potent photosensitizer with desirable immunogenic cell death (ICD) ability can prominently enhance antitumor immunity in...
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Biomimetic nanodrug blocks CD73 to inhibit adenosine and boosts antitumor immune response synergically with photothermal stimulation
Combination of tumor immunotherapy with photothermal therapy (PTT) is a feasible tactic to overcome the drawback of immunotherapy such as poor immune...
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Design, synthesis and antitumor activity of new naproxen based 1,2,4-triazole-Schiff base derivatives
In the present work, new Naproxen based 1,2,4-triazole-Schiff base derivatives have been synthesized and screened for in vitro antitumor activity and...
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Design, Synthesis, and Biological Evaluation of Novel Pyrazolo[1,5-a]pyrimidine and 1,3-Benzodiazine Derivatives as Potent Antitumor Agents
AbstractBased on the molecular docking simulation and structure of larotrectinib, some larotrectinib derivatives as antitumor compounds were designed...
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Taking SCFAs produced by Lactobacillus reuteri orally reshapes gut microbiota and elicits antitumor responses
BackgroundColorectal cancer (CRC) incidence is increasing in recent years due to intestinal flora imbalance, making oral probiotics a hotspot for...
