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Synthesis, Antitubercular Evaluation, Molecular Docking Study, and Teratogenicity Studies of Novel Triazolo Quinazoline Hybrids
AbstractA novel series of triazole-quinazoline hybrid molecules was synthesized and characterized by spectral analyses. The H37 R V strain was used...
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Sonochemical Synthesis and In Silico Studies of Phthalazine Scaffolds Bearing 1,3,4-Oxadiazolyl-1,2,3-triazoles as Potent Antitubercular Agents
AbstractThe sonochemical synthesis and biological properties of compounds simultaneously containing several heterocycles, namely phthalazine,...
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Liposomes for Delivery of Antitubercular Drugs
TB is a severe infectious disease that is yet to be eradicated and controlled. The ongoing therapy of TB (DOTS strategy) is associated with certain...
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Synthesis, Molecular Docking, and Antitubercular Evaluation of Triazole–Chalcone Conjugates
AbstractThe condensation of propargylated vanillin with differently substituted acetophenones produced the corresponding chalcones which were reacted...
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Inverse Molecular Docking and Evaluation of Antitubercular Activities of Some Quinoline Based Heterocyclic Compounds
Mycobacterium tuberculosis , the causative bacterium of tuberculosis (TB), is a serious infectious disease and if not treated properly, TB disease can...
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The synthesis and antitubercular activity of 4,5-dihydro-1H-pyrazole derivatives with a basic epoxybenzo[7,8]oxocine framework
The corresponding pyridyl chalcones were synthesized by the aldol-crotonic condensation of the acetyl derivative of epoxybenzo[7,8]-oxocino[4,3- b ]pyri...
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Synthesis and Molecular Docking Study of Arylsulfanyl Pyrazolylpyrazoline Derivatives as Antitubercular Agents
AbstractNew arylsulfanyl pyrazolylpyrazoline derivatives were synthesized via a facile protocol, and their structure was confirmed by FT-IR, 1 H and 13 ...
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Synthesis and Antitubercular Activity of New 5-Alkynyl Derivatives of 2-Thiouridine
AbstractNew efficient mycobacterial inhibitors based on 5-substituted 2-thiouridine derivatives have been described. A series of new...
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Bis-triazole Heterocycles as Antitubercular and Antimicrobial Agents: Synthesis Using Copper-Catalyzed Click Chemistry Approach
AbstractA series of bis-triazole conjugates, N -aryl-2-(4-{[(1 H -1,2,3-benzotriazol-1-yl)oxy]methyl}-1 H -1,2,3-triazol-1-yl)acetamides, have been...
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Synthesis and Biological Importance of Pyrazole, Pyrazoline, and Indazole as Antibacterial, Antifungal, Antitubercular, Anticancer, and Anti-inflammatory Agents
N-heterocycles have always gained greater attention among the scientific community. Indole, indazole, pyrrole, pyrazole, pyrazoline, pyridine,...
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Synthesis, characterization, antimicrobial and antitubercular evaluation of nickel (II) complexes of ON donor quinoline-hydrazide core
In the current work, non-toxic and safe Ni(II) complexes of unsymmetrical Schiff base ligand derived from Quinoline hybrid and isoniazid, viz. [Ni II (Quibal-INH)...
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Green and Catalyst-Free Synthesis of Some New Benzo[4,5]imidazo[1,2-a]pyrimidine Derivatives as Antimicrobial and Antitubercular Agents
AbstractA new series of 4-(1 H -imidazol-4-yl)-2-(substituted phenyl)-1,4-dihydrobenzo[4,5]imidazo[1,2- a ]pyrimidines have been synthesized via a...
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One-Pot Multiсomponent Synthesis and Characterization of Some New Pyrazolylpyrazoline Scaffolds as Antitubercular and Antimalarial Agents
AbstractA new, facile, and environment friendly synthesis of some novel pyrazolylpyrazoline derivatives has been achieved using one-pot...
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e-Pharmacophore model-guided design of potential DprE1 inhibitors: synthesis, in vitro antitubercular assay and molecular modelling studies
Tuberculosis continues to wreak havoc worldwide and caused around 1.4 million deaths in 2019. Hence, in our pursuit of develo** novel...
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Concise route to stereoselective chlorobenzene-based spiropyrrolidine oxindoles for pursuit as antitubercular agents
A chemoselective chlorination of nitroolefin was accomplished, and the resulting monochlorinated nitroolefin underwent [3+2]-cycloadditions with in-situ...
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Exploring biogenic chalcones as DprE1 inhibitors for antitubercular activity via in silico approach
Cases of drug-resistant tuberculosis (TB) have increased worldwide in the last few years, and it is a major threat to global TB control strategies...
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Synthesis of some novel piperidine fused 5-thioxo-1H-1,2,4-triazoles as potential antimicrobial and antitubercular agents
AbstractA novel series of analogues based on 5-(1-(4-chloro-3-methoxyphenyl)piperidin-4-yl)-4-phenyl-2 H -1,2,4-triazole-3(4 H )-thione core have been...
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Design, Synthesis, Antitubercular and Antibacterial Activities of 1,3,5-Triazinyl Carboxamide Derivatives and In Silico Docking Studies
AbstractA series of novel N -{2-fluoro-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)methyl]phenyl} carboxamide derivatives has been synthesized, and their...
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Ruthenium Polypyridyl Complexes with Hydroxypyridine: Experimental, DFT Studies, and In Silico Antitubercular Activity Investigation
This study reports the synthesis, spectroscopic, molecular properties, and in silico biological assessment of ruthenium polypyridyl complexes with a...
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Recent developments on the synthesis of copper and cobalt-Schiff base complexes and their assessment as anti-tuberculosis drugs
The World Health Organization has identified tuberculosis (TB) as one of the major global health hazards and designated it as a “global public health...
