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RNA modulates hnRNPA1A amyloid formation mediated by biomolecular condensates
Several RNA binding proteins involved in membraneless organelles can form pathological amyloids associated with neurodegenerative diseases, but the...
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Structural mechanism for specific binding of chemical compounds to amyloid fibrils
Amyloid fibril is an important pharmaceutical target for diagnostic and therapeutic treatment of neurodegenerative diseases. However, rational design...
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Wheat flour-derived amyloid fibrils for efficient removal of organic dyes from contaminated water
Amyloid fibrils derived from different proteins have been proved as a promising material for adsorption of various pollutants from wastewater, which...
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Solid-State NMR Structure of Amyloid-β Fibrils
Amyloid fibrils are involved in a number of diseases and notably play a role in neurodegeneration, where they are present in plaques in the brain....
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O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology
Amyloid-forming proteins such α-synuclein and tau, which are implicated in Alzheimer’s and Parkinson’s disease, can form different fibril structures...
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Preparation of Tau Condensates by Liquid–Liquid Phase Separation to Study Tau Amyloid Aggregation
Protein liquid–liquid phase separation (LLPS) has been associated with protein amyloid aggregation. Amyloid aggregation of tau is a hallmark of...
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Disaggregation of amyloid-beta fibrils via natural metabolites using long timescale replica exchange molecular dynamics simulation studies
ContextAmyloid fibrils are self-assembled fibrous protein aggregates that are associated with several presently incurable diseases such as...
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Simulations of Amyloid-Forming Peptides in the Crystal State
There still is little treatment available for amyloid diseases, despite their significant impact on individuals and the social and economic...
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The interface of condensates of the hnRNPA1 low-complexity domain promotes formation of amyloid fibrils
The maturation of liquid-like protein condensates into amyloid fibrils has been associated with several neurodegenerative diseases. However, the...
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Structure-specific amyloid precipitation in biofluids
The composition of soluble toxic protein aggregates formed in vivo is currently unknown in neurodegenerative diseases, due to their ultra-low...
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Cross-Seeding Assay in the Investigation of the Amyloid Core of Prion Fibrils
Amyloidogenesis, self-propagation of protein or peptide monomers to amyloid fibrils, has been linked to incurable pathogenesis of neurodegenerative...
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Investigating the effect of cerium oxide nanoparticle on beta-amyloid-induced memory loss
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the loss of nerve cells in the hippocampus region of the brain, leading to...
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Development of a nanohybrid system by selenium nanoparticles and lysozyme amyloid fibrils with improved conductivity and antibacterial activity
Today, nanoparticles have promised a variety of applications in conjugation with biomolecules. Selenium nanoparticles (SeNPs) have shown to be...
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The Role of Buffers in Wild-Type HEWL Amyloid Fibril Formation Mechanism: A Methodological Approach
The amyloidophilic dyes thioflavin T and Congo red are small, yet powerful, molecules that allow the in vitro and in vivo detection of amyloid...
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Probing Amyloid-DNA Interaction with Nanofluidics
Nanofluidics is an emerging methodology to investigate single biomacromolecules without functionalization and/or attachment of the molecules to a...
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Anti-Amyloid Drug Screening Methods Using Bacterial Inclusion Bodies
Amyloid aggregation is linked to a number of human disorders that range from non-neurological illnesses such as type 2 diabetes to neurodegenerative...
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Evaluation of Amyloid Inhibitor Efficiency to Block Bacterial Survival
Amyloid inhibitors, such as the green tea compound epigallocatechin gallate EGCG, apomorphine or curlicide, have antibacterial properties....
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Variable fragmentation and ionization of amyloid-beta epimers and isomers
While the existence of D -amino acids in peptides and proteins has recently been accepted in higher forms of life, their roles and importance are yet...
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α-Synuclein Fibril, Ribbon and Fibril-91 Amyloid Polymorphs Generation for Structural Studies
The human α-synuclein protein, identified as one of the main markers of Parkinson’s disease, is a 140-amino acid thermostable protein that can easily...
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Study of Amyloid Fibers Using Atomic Force Microscopy
Atomic force microscopy (AFM) provides high-resolution images of the topography of amyloid fibers adsorbed on surfaces. This information is very...