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Genome-scale metabolic modeling underscores the potential of Cutaneotrichosporon oleaginosus ATCC 20509 as a cell factory for biofuel production
BackgroundCutaneotrichosporon oleaginosus ATCC 20509 is a fast-growing oleaginous basidiomycete yeast that is able to grow in a wide range of...
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Advances in the optimization of central carbon metabolism in metabolic engineering
Central carbon metabolism (CCM), including glycolysis, tricarboxylic acid cycle and the pentose phosphate pathway, is the most fundamental metabolic...
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Increasing lipid yield in Yarrowia lipolytica through phosphoketolase and phosphotransacetylase expression in a phosphofructokinase deletion strain
BackgroundLipids are important precursors in the biofuel and oleochemical industries. Yarrowia lipolytica is among the most extensively studied...
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Reconstruction of genome-scale metabolic models of non-conventional yeasts: current state, challenges, and perspectives
Non-conventional yeasts are promising cell factories to produce lipids and oleochemicals, metabolites of industrial interest ( e.g ., organics acids,...
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Blastobotrys adeninivorans and B. raffinosifermentans, two sibling yeast species which accumulate lipids at elevated temperatures and from diverse sugars
BackgroundIn the context of sustainable development, yeast are one class of microorganisms foreseen for the production of oil from diverse renewable...
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Fermentation performance and metabolomic analysis of an engineered high-yield PUFA-producing strain of Schizochytrium sp.
The ω-3/long-chain polyunsaturated fatty acids (LC-PUFAs) play an important role in human health, but they cannot be synthesized in sufficient...
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In silico identification of metabolic engineering strategies for improved lipid production in Yarrowia lipolytica by genome-scale metabolic modeling
BackgroundYarrowia lipolytica , an oleaginous yeast, is a promising platform strain for production of biofuels and oleochemicals as it can accumulate...
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Engineering of an oleaginous bacterium for the production of fatty acids and fuels
Production of free fatty acids (FFAs) and derivatives from renewable non-food biomass by microbial fermentation is of great interest. Here, we report...
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Develo** a set of strong intronic promoters for robust metabolic engineering in oleaginous Rhodotorula (Rhodosporidium) yeast species
BackgroundRed yeast species in the Rhodotorula/Rhodosporidium genus are outstanding producers of triacylglyceride and cell biomass. Metabolic...
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The dilemma for lipid productivity in green microalgae: importance of substrate provision in improving oil yield without sacrificing growth
Rising oil prices and concerns over climate change have resulted in more emphasis on research into renewable biofuels from microalgae. Unlike plants,...
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Proteomics analysis of high lipid-producing strain Mucor circinelloides WJ11: an explanation for the mechanism of lipid accumulation at the proteomic level
BackgroundThe oleaginous fungus, Mucor circinelloides , is attracting considerable interest as it produces oil rich in γ-linolenic acid. Nitrogen (N)...
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Cell Factories of Higher Fungi for Useful Metabolite Production
Higher fungi or called as macro-fungi, consisting of the divisions ascomycetes, basidiomycetes, and imperfect fungi, are receiving great interest...
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Comparison of biomass production and total lipid content of freshwater green microalgae cultivated under various culture conditions
The growth and total lipid content of four green microalgae ( Chlorella sp., Chlorella vulgaris CCAP211/11B, Botryococcus braunii FC124 and Scenedesmus...
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Mechanisms controlling lipid accumulation and polyunsaturated fatty acid synthesis in oleaginous fungi
Polyunsaturated fatty acids (PUFAs) are functional lipids that have been widely incorporated into several industrial sectors. Apart from animal- and...
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Enhanced docosahexaenoic acid production by reinforcing acetyl-CoA and NADPH supply in Schizochytrium sp. HX-308
Docosahexaenoic acid (DHA) production in Schizochytrium sp. HX-308 was evaluated by detecting enzymatic activities of ATP:citrate lyase (EC 4.1.3.8),...
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Overexpression of Acetyl-CoA Carboxylase Gene of Mucor rouxii Enhanced Fatty Acid Content in Hansenula polymorpha
Malonyl-CoA is an essential precursor for fatty acid biosynthesis that is generated from the carboxylation of acetyl-CoA. In this work, a gene coding...
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Filamentous Fungi for Production of Food Additives and Processing Aids
Filamentous fungi are metabolically versatile organisms with a very wide distribution in nature. They exist in association with other species,...
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Lipid and γ-linolenic acid accumulation in strains of zygomycetes growing on glucose
Strains of Zygomycetes, belonging to the genera Zygorhynchus, Mortierella, Rhizopus, Mucor, and Cunninghamella , when cultivated on glucose produced...
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Purification and properties of carnitine acetyltransferase from citric acid producingAspergillus niger
Carnitine acetyltransferase was purified from the citric acid producing A. niger mycelium with a protein band showing a relative molecular weight of...
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The effect of temperature on lipid classes and their fatty acid profiles inLipomyces starkeyi
The effect of environmental temperature on fatty acid contents of major lipid classes was determined in Lipomyces starkeyi at 30, 20, and 10°C. When...