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Diastereoselective Synthesis of 3-[2-Chloro(bromo)phenyl]-2-methyl-2-[(prop-2-yn-1-yl)oxy]oxiranes and 5-[3-Chloro(bromo)phenyl]-2,2,4-trimethyl-4-[(prop-2-yn-1-yl)]-1,3-dioxolane
AbstractThe reaction of halogen-substituted benzaldehydes with 3-(1-chloroethoxy)prop-1-yne leads to the formation of unsaturated ethers derived from...
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Synthesis of 1-[(1,1′-biphenyl)-4-yl]naphthalene from amines obtained by the Stevens rearrangement of N-[3-(naphthalen-1-yl)prop-2-yn-1-yl]-3-phenylprop-2-en-1-aminium bromides
A convenient procedure to access 1-[(1,1′-biphenyl)-4-yl]naphthalene by the Stevens rearrangement of the aminium salts bearing simultaneously...
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Iodination of Propargylpyrazole in the Presence of Cadmium(II) Acetate
AbstractAn efficient procedure has been proposed for the addition of iodine to the triple bond and substitution of the terminal hydrogen atom of...
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A Facile Synthesis of 3,5-Dibenzylidene-1-(1-benzyl-1H-1,2,3-triazol-4-ylmethyl)piperidin-4-ones
AbstractA new copper(I) catalytic system has been developed for the alkyne–azide click reaction. 3,5-Dibenzylidene-1-(prop-2-yn-1-yl)piperidin-4-ones...
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Base-Catalyzed Intramolecular Cycloaddition of Dialkyl(4-hydroxybut-2-yn-1-yl)[3-(4-bromophenyl)prop-2-yn-1-yl]ammonuim Chlorides and Recyclization of the Products
Dialkyl(4-hydroxybut-2-yn-1-yl)[3-(4-bromophenyl)prop-2-yn-1-yl]ammonium chlorides in the presence of 2 equiv of potassium hydroxide at room...
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Microwave-Assisted Synthesis and Evaluation of Bis[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl] 7,8′-Methylenebis[2-(E)-(benzylideneamino)-4H-chromene-3-carboxylates] as Potent Antimicrobial Agents
AbstractA series of novel bis[(1-benzyl-1 H -1,2,3-triazol-4-yl)methyl] 7,8′-methylenebis[2-( E )-(benzylideneamino)-4 H -chromene-3-carboxylates] 6a – 6f ...
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Copper(I)-Catalyzed Regioselective Synthesis of 1,2,3-Triazole–Phthalazine-1,4-dione Hybrids, and Their Anticancer and Molecular Docking Studies
AbstractA new series of phthalazine-based 1,2,3-triazole derivatives were synthesized by the copper-catalyzed azide–alkyne cycloaddition of...
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Synthesis and Antimicrobial Activity of Novel (1-Aryl-1H-1,2,3-triazol-4-yl)methyl 3-Acetamido-1-phenyl-1H-benzo[f]chromene-2-carboxylates
AbstractA series of novel (1-aryl-1 H -1,2,3-triazol-4-yl)methyl 3-acetamido-1-phenyl-1 H -benzo[ f ]chromene-2-carboxylates were synthesized from...
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Synthesis of azidopropargylamino-substituted 1,3,5-triazines – novel monomers for the production of energetic polymers
Efficient methods for the synthesis of novel azidopropargylamino-substituted 1,3,5-triazines were developed. 4,6-Diazido- N -(prop-2-yn-1-yl)-1,3,5-tria...
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Synthesis and Anticancer Activity of Some New 4-Azaindoleisoxazoles
AbstractHerein, synthesis of new 4-azaindole-1,2,4-isoxazoles by Cu(I)-catalyzed 1,3-dipolar cycloaddition reaction of...
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Synthesis and Anticancer Activity of 3,4,5-Trimethoxycinnamamide-Tethered 1,2,3-Triazole Derivatives
AbstractA series of novel 3,4,5-trimethoxycinnamamide-tethered 1,2,3-triazole derivatives were prepared by the click reaction of ( E )- N -(prop-2-yn-1-y...
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Chiral discrimination of enantiomers based on different interactions with alterable chiral oligomer
Series of chiral oligomer ((S)-1-(S)-7)) based on the different proportions of achiral fluorophore unit (9, 9-dipropyl alkynyl fluorene (1a)) and...
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Silver-assisted palladium-catalyzed one-pot synthesis of 3-(hetero)arylmethyl derivatives of imidazo[1,2-a]pyridines
3-(Hetero)arylmethyl derivatives of imidazo[1,2- a ]pyridine have been synthesized by a novel one-pot method consisting of the Sonogashira coupling of tert...
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Copper(I)-Catalyzed Click Chemistry-Based Synthesis and Antimicrobial Evaluation of Triazolopyridine–Triazole Congeners
AbstractIn an effort to find a new pharmacologically dynamic molecule, we report here the synthesis and in vitro antimicrobial activity of N -phenyl-2-(4-{[(3...
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Synthesis of New Thieno[2,3-d]pyrimidines Containing a 1,2,3-Triazole Ring and Their Therapeutic Response in NCI-60 Cell Line Panel
AbstractA series of new tetrahydro[1]benzothieno[2,3- d ]pyrimidines containing a 1,2,3-triazole fragment linked through an oxymethylene spacer...
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The First Analog of Pyrimidine Nucleosides with Two Nucleobases and Two d-Ribofuranose Residues
AbstractThe reaction of 1,5-bis[1-(prop-2-yn-1-yl)uracil-3-yl]pentane with 2',3',5'-tri- O -acetyl-β-d-ribofuranosylazide followed by removing of...
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Synthesis of 4-Bromo-1,1′:4′,1″-terphenyl and 4-Methyl-1,1′:4′,1″-terphenyl
AbstractPossible synthetic routes to 4-bromo-1,1′:4′,1″-terphenyl and 4-methyl-1,1′:4′,1″-terphenyl have been studied. Stevens rearrangement of...
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Ligand-assisted click reaction for the synthesis of new hybrid compounds based on 1,2,3-triazoles and 5,5-diphenylimidazolidine-2,4-dione and evaluation of their antibacterial activities
The new hybrid compounds based on 1,2,3-triazoles and 5,5-diphenylimidazolidine-2,4-dione were successfully synthesized by copper-catalyzed click...
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A convenient one-pot synthesis of novel heterocyclic systems of 9-chloro-4-methyl-6,11-dihydro-5H-benzo[b]pyrimido[4,5-e][1,4]diazepine and inhibitory evaluation against bromodomain-containing protein 4 (BRD4) enzyme by molecular docking
A convenient one-pot two-step strategy for synthesis of the novel tricyclic system 9-chloro-4-methyl-6,11-dihydro-5 H -benzo[ b ]pyrimido[4,5- e ][1,4]diaze...
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Synthesis of [3-(trimethylsilyl)prop-2-yn-1-yl] selenides
Efficient and selective methods have been developed for the synthesis of previously unknown organyl [3-(trimethylsilyl)prop-2-yn-1-yl] selenides,...