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Synthesis of Novel Tetrahydropyrimido[4,5-B][1,6]Naphthyridines via Condensation of 1-benzyl-3,5-bis[(E)-arylmethylidene]tetrahydropyridin-4(1H)-ones with 6-aminouracils
The successful synthesis of novel tetrahydropyrimido[4,5- b ][1,6]naphthyridine derivatives is reported. 1-Benzyl-3,5-bis[( E )-arylmethylidene]...
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Review: synthesis and anticancer activity of pyrimido[4,5-b]quinolines in the last twenty years
Pyrimido[4,5- b ]quinoline is a vital structural motif. The synthesis of pyrimido[4,5- b ]quinolines has been a challenging topic in medicinal chemistry....
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Pushing Boundaries: What’s Next in Metal-Free C–H Functionalization for Sulfenylation?
The synthesis of thioether derivatives has been explored widely due to the potential application of these derivatives in medicinal chemistry,...
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Catalyst-free, efficient, and green procedure for the synthesis of 5-heterocyclic substituted 6-aminouracils
AbstractIn this paper, the results of our studies on the catalyst-free synthesis of some new 6-aminouracils bearing naphthoquinone, benzo[ a ]phenazine...
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Synthesis of Spiro(pyrrol-2,5'-pyrrolo[2,3-d]pyrimidine)-2',4',5,6'-tetraones by the Reaction of Pyrrolo[2,1-c][1,4]oxazinetriones with 6-Aminopyrimidine-2,4-diones
Abstract8-Aroyl-3,4-dihydro-1 H -pyrrolo[2,1- c ][1,4]oxazine-1,6,7-triones react with 6-aminopyrimidine-2,4(1 H ,3 H )-diones to form...
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Multicomponent domino protocol for the one-pot synthesis of novel benzo[a]phenazin-5-ol derivatives
A one-pot, two-step, four-component synthesis of novel benzo[a]phenazin-5-ol derivatives was carried out by the condensation-Michael addition...
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Spectral-Luminescent Study of the Acid–Base Equilibrium of 5-Aminouracil and 6-Aminouracil in Aqueous Solutions
AbstractThe spectral fluorescence characteristics of 5-aminouracil (5AU) and 6-aminouracil (6AU) in neutral and alkaline aqueous solutions have been...
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Synthesis of new tetrahydrobenzo[b]pyrimido- [5,4-g][1,8]naphthyridine-2,4-diones from 6-aminouracils
Cyclocondensation of N-substituted 6-aminouracils with 3- and 7-methyl-2-iodoquinoline-3-carbaldehydes gave the corresponding 12- or 9,12-substituted...
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Multicomponent Reactions Using C,N-Binucleophilic Nature of Aminopyrazoles: Construction of Pyrazole-Fused Heterocycles
Synthesis of pyrazole-fused heterocycles has gained considerable attention in recent years due to their wide applications in medicinal chemistry....
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Efficient Synthesis of Pyrido[2,3-d]pyrimidines by Recyclization of N-Arylitaconimides with Aminopyrimidinones
AbstractA convenient method has been proposed for the synthesis of 2-(4,7-dioxopyrido[2,3- d ]pyrimidin-6-yl)acetanilides and...
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Reaction of 1,4-Benzoquinone with 2-(2-Oxo-2-arylethylidene)-2,3-dihydropyrimidine-4(1H)-ones
AbstractReactions of 1,4-benzoquinone with 2-(2-oxo-2-arylethylidene)-2,3-dihydro-1 H -pyrimidine-4-ones in glacial acetic acid proceed selectively to...
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Synergistic Effect for a Mixture of 3-Butyl-5-Amino-6-Methyluracil and Butylated Hydroxytoluene during Inhibited Styrene Autoxidation
AbstractThe antioxidant effect of a mixture of 3-butyl-5-amino-6-methyluracil and butylated hydroxytoluene (BHT) was studied in a model system of...
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Reactions of cyclic β-alkoxyvinyl α-keto esters with heteroaromatic NCC-binucleophiles
Reactions of five- and six-membered cyclic β-alkoxyvinyl α-keto esters and NCC-binucleophiles are described. The following binucleophiles were...
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Metal-Free Catalysis in C–C Single-Bond Cleavage: Achievements and Prospects
This review article emphasizes the C–C bond cleavage in organic synthesis via metal-free approach. Conventional organic synthesis mainly deals with...
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Reaction of trifluoroacetylchromenes with 6-aminouracils. Synthesis of pyrido[2,3-d]pyrimidines
The condensation of trifluoroacetyl-substituted 4 H -chromenes and 1 H -benzo[ f ]chromenes with 6-amino-1,3-dimethyluracil and 6-aminothiouracil afforded...
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Recent advances in the C(1)-functionalization of tetrahydroisoquinolines via multicomponent reactions
1,2,3,4-Tetrahydroisoquinoline is an important structural motif of various natural products and therapeutic lead compounds. In recent years,...
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Multicomponent synthetic strategies and perspectives for synthesis of linked or fused coumarin heterocycles
Natural and synthetic hybrid molecules are an attractive scaffold for therapeutic agent development due to their dual/multiple modes of action,...
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Annulation of 6-aminouracils with 2,3-dimethoxy- and 2-fluorobenzaldehydes and 2-chloro-7-methoxyquinoline-3-carbaldehyde
6-R-Aminouracils reacted with 2,3-dimethoxybenzaldehyde to give 10-R-substituted 9-methoxy-5-deazaflavins. No expected 5-deazaflavins were obtained...
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Pro- and antioxidant properties of uracil derivatives
The review summarizes data on pro- and antioxidant properties of uracil derivatives comprising an important group of pharmacologically active...
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New Syntheses and Properties of Some Axial and Helical Isomers of Organic Compounds
The review generalizes published data on the synthesis of atropisomeric arylimide, porphyrin, and benzimidazole derivatives, helically chiral...