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Organocatalysis in 1,3-Dipolar Cycloaddition Reactions (A Review)
AbstractOne of the promising directions in 1,3-dipolar cycloaddition is the implementation of these reactions under organocatalysis conditions, which...
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Arenes participate in 1,3-dipolar cycloaddition with in situ-generated diazoalkenes
The venerable 1,3-dipolar cycloaddition has been widely used in organic synthesis for the construction of various heterocycles. However, in its...
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Copper-catalyzed asymmetric 1,3-dipolar cycloaddition of azomethine ylides with β-trifluoromethyl-substituted alkenyl heteroarenes
Copper-catalyzed asymmetric 1,3-dipolar cycloaddition of azomethine ylides and β-trifluoromethyl-substituted alkenyl heteroarenes was developed for...
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Synthesis of 5-ethynylisoxazoles based on 1,3-dipolar cycloaddition reactions of nitrile oxides with conjugated diynes
New 5-ethynylisoxazoles were obtained via 1,3-dipolar cycloaddition reactions of nitrile oxides with buta-1,3-diynes. The cycloaddition proceeds...
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1,3-Dipolar Cycloaddition of Stable Azomethine Ylide Based on Ninhydrin and L-Proline to Phosphorylated Acetylenes
AbstractThe reaction of 1,3-dipolar cycloaddition of a stable azomethine ylide formed from ninhydrin and L-proline to activated acetylenic...
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Synthesis of Benzothiazole-Fused meso-Tetrakis(pentafluorophenyl)chlorin Through 1,3-Dipolar Cycloaddition Reaction
AbstractThe 1,3-dipolar cycloaddition reaction of 2-nitro- meso -tetrakis(pentafluorophenyl)porphyrin and azomethine ylide, generated in situ by...
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Organocatalytic Diastereoselective Synthesis of Spiro[3-azabicyclo[3.1.0]hexanes] via 1,3-Dipolar Cycloaddition of Azomethine Ylides with Cyclopropenes
AbstractA three-component organocatalytic reaction of 1,3-dipolar cycloaddition between the in situ generated azomethine ylides and 3-substituted...
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Synthesis of Spiro[pyrrole-3,2'-pyrrolo[2,1-b]oxazoles] via 1,3-Dipolar Cycloaddition of 1H-Pyrrole-2,3-diones to Azomethine Ylides
AbstractThe 1,3-dipolar cycloaddition of 1 H -pyrrole-2,3-diones to azomethine ylides generated in situ by the condensation of L-proline and...
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Cyclopropenes and methylenecyclopropanes in 1,3-dipolar cycloaddition reactions
The review considers the main results of the cycloaddition reactions involving cyclopropenes and methylenecyclopropanes, the compounds bearing...
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A 1,3-dipolar cycloaddition of azomethine ylides to imidazo[4,5-e]thiazolo[2,3-c][1,2,4]triazine oxindolylidene derivatives in the synthesis of novel spirooxindole derivatives
The stereochemistry of the 1,3-dipolar cycloaddition reaction of azomethine ylides to oxindolylidene derivatives of imidazo[4,5- e ]-thiazolo[2,3- c ][1,2...
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1,3-Dipolar Cycloaddition of Nitrones to Methyl {4-[(2E)-3-(4-Methoxyphenyl)prop-2-enoyl]phenyl}carbamate
Abstract1,3-Dipolar cycloaddition of nitrones to methyl {4-[(2 E )-3-(4-methoxyphenyl)prop-2-enoyl]phenyl}carbamate regioselectively afforded the...
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A metal-free approach for in situ regioselective synthesis of isoxazoles via 1,3 dipolar cycloaddition reaction of nitrile oxide with propargyl bromide
Herein, we report a multi-component reaction (MCRs) to synthesise a range of 3-phenyl-5-(bromomethyl)isoxazoles analogues using DMF/water mixture as...
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One-Step Three-Component Synthesis of Spiro Pyrrolidinones via 1,3-Dipolar Cycloaddition
AbstractThree-component 1,3-dipolar cycloaddition reactions between isatin, benzylamine, and α,β-unsaturated ketones at room temperature afforded...
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Synthesis and Biological Activities of Diosgenin-Triazole Conjugates with a 1,3-Dipolar Cycloaddition Reaction
A novel series of diosgenin-triazole conjugates ( 10a–d , 11a–c , 12a–c , 13a–c ) was designed and synthesized as antifungal agents by using a 1,3-dipolar...
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A robust three-component synthesis of dispiroheterocycles containing aurone scaffold via 1,3-dipolar cycloaddition reaction of azomethine ylides: regioselectivity and mechanistic overview using DFT calculations
Highly regioselective synthesis of 12 new dispiroheterocycles containing aurone scaffold was reported via a three-component 1,3-dipolar cycloaddition...
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Asymmetric catalytic 1,3-dipolar cycloaddition of α-diazoesters for synthesis of 1-pyrazoline-based spirochromanones and beyond
A highly enantioselective 1,3-dipolar cycloaddition of α-substituted diazoesters with exocyclic enones was achieved with chiral scandium(III)/ N , N ’-dio...
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Synthesis of Dispiro[indeno[1,2-b]quinoxaline] Derivatives via 1,3-Dipolar Cycloaddition Reactions
Abstract1,3-Dipolar cycloadditions of ( E )-7-(arylmethylidene)-6,7-dihydroindolizin-8(5 H )-one and ( E )-2-(arylmethylidene)-2,3-dihydro-1 H -pyrrolizin-1-...
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Conjugation of 1-Aminoadamantanes and 5-Trifluoromethylhydantoins by 1,3-Dipolar Cycloaddition
AbstractA synthetic approach was proposed for combining pharmacophore scaffolds, namely, 1-aminoadamantanes and 5-trifluoromethylhydantoins by the...
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Exploring the maximum Fukui function sites with the frontier-controlled soft-soft reactions using 1,3-dipolar cycloaddition reactions of nitrilium betaines
According to P.K. Chattaraj. J Phys Chem A 2001, 105, 511-513 “ the maximum Fukui function site is the best for the frontier-controlled soft-soft...
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Heterocycles from Cycloaddition Reactions
The synthesis of heterocyclic compounds via catalytic cycloaddition reactions of metallocarbenes is robust, atom-economic, and often allows access to...