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Synthesis of Betulin Conjugates and Its 1,2,3-Triazole Derivatives
AbstractThis review summarizes the main methods to introduce a triazole moiety into the structures of a pentacyclic triterpenoid betulin and its...
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Synthesis, Spectral Analysis, and Insecticidal Activity of 1,2,3-Triazole Derivatives
AbstractA series of ( E )-5-{[(1 H -1,2,3-triazol-5-yl)sulfanyl]methyl}-4-(benzylideneamino)-4 H -1,2,4-triazole-3-thiols were synthesized using...
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Quinolone Tethered 1,2,3-Triazole Conjugates: Design, Synthesis, and Molecular Docking Studies of New Heterocycles as Potent Antimicrobial Agents
AbstractOur current work is aimed to synthesizing novel derivatives of 1,2,3-triazolyl-2-quinolone and applying docking studies and biological...
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Microwave-Assisted Synthesis, Molecular Docking, and Insecticidal Activity of 1,2,3-Triazole-Linked Chromone Derivatives
AbstractThe current study was carried out in an attempt to synthesize a new class of 1,2,3-triazole-linked hybrids by Cu(I)-catalyzed azide-alkyne...
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Expedient Synthesis of Coumarin–1,2,3-Triazole Hybrids via Click Chemistry and Their Antimicrobial Evaluation
AbstractThis study focuses on the synthesis of aromatic and heteroaromatic triazole derivatives known for their versatile therapeutic potential in...
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Synthesis, Anticancer Evaluation, and Molecular Docking Study of 1,2,3-Triazole-Containing Hydrazones as Potential HER2 Kinase Inhibitors
AbstractA library of 1,2,3-triazole-containing hydrazones have been synthesized via Cu(I)-mediated 1,3-dipolar cycloaddition reaction. The...
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Synthesis of Dinitramide Salt of 1-Amino-1,2,3-triazole
AbstractIt was shown that dinitraminic acid easily interacts with 1-amino-1,2,3-triazole in quantitative yield to form the corresponding high-density...
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Design, Synthesis, Molecular Docking Study, and Biological Evaluation of Some New 1,2,3-Triazole Derivatives as Anticancer and Antioxidant Agents
AbstractA series of new 1,2,3-triazole derivatives was synthesized via a 1,3-dipolar cycloaddition reaction. Structures of the synthesized compounds...
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Highly regioselective one-step synthesis of 1-benzyl-5-formyl-1,2,3-triazole-4-carboxylates
A novel methodology has been developed to afford 1,4,5-trisubstituted 1-benzyl-5-formyl-1,2,3-triazole-4-carboxylates in one step under mild...
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Synthesis of novel indole-oxindole clubbed 1,2,3-triazole hybrids: antimicrobial evaluation and molecular docking study
A new series of indole-oxindole clubbed 1,2,3-triazole hybrids 5(a–o) was thoughtfully designed and synthesized via Cu-catalysed azide-alkyne...
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Synthesis of Novel Hybrids Containing 1,2,3-Triazole-Linked Tetrazole Moieties, Evaluation of Anticancer Activity and Molecular Docking Studies
AbstractNovel hybrids containing 1,2,3-triazole linked tetrazole derivatives were synthesized and characterized by various analytical techniques like
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Hg(OAc)2/1,2,3-triazole-mediated efficient synthesis of Tazobactam
A short and simple synthesis of 2β-(1,2,3-Triazol-1-yl) methyl-2α-methyl-6,6-dihydropenicillin-3α-carboxylic acid diphenylmethyl ester ( 7 ), on...
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Activity of bimetallic gold–copper catalysts in the photodegradation of malachite green and the photosynthesis of 1,2,3-triazole derivatives
The aim of this work is to study the properties of gold and copper nanoparticles supported on titanium dioxide catalysts, their application in the...
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Synthesis of a novel chloroquinoline, rhodanine encompassed 1,2,3-triazole scaffolds and molecular docking evaluation of their cytotoxicity
A novel series of quinoline-linked rhodanine bearing 1,2,3-triazole analogs ( 10a-l ) have been designed and prepared. All the novel hybrids were...
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Synthesis and antitumor activity of dolutegravir derivatives bearing 1,2,3-triazole moieties
Modification of marketed drugs is an important way to develop drugs because its safety and clinical applicability. Oxygen-nitrogen heterocycles are a...
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Copper(I)-Catalyzed Regioselective Synthesis of 1,2,3-Triazole–Phthalazine-1,4-dione Hybrids, and Their Anticancer and Molecular Docking Studies
AbstractA new series of phthalazine-based 1,2,3-triazole derivatives were synthesized by the copper-catalyzed azide–alkyne cycloaddition of...
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Design, Synthesis, In Silico Screening, and Antiproliferative Activity of Novel 1,2,3-Triazole Tethered Dibenzosuberane Conjugates
To explore novel and potent compounds with anticancer activity, two series of 1H-1,2,3-triazole tethered dibenzosuberane conjugates ( 5a-i and 5j-n )...
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Synthesis, Characterization and Antimicrobial Evaluation of Novel Imidazo[1,2-a]pyrazine-linked 1,2,3-Triazole Derivatives via a Click Chemistry Approach
AbstractThis work summarizes the results of the synthesis of imidazo[1,2- a ]pyrazine-linked 1,2,3-triazole derivatives and provides evidence for the...
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Anticancer Activity and Molecular Docking of 1,2,3-Triazole Hybrids of Phenol and 4-Methoxy-2-methylphenyl: Synthesis via Click Chemistry
AbstractThe click chemistry approach was utilized to synthesize 1,2,3-triazole derivatives from 1-ethynyl-4-methoxy-2-methylbenzene or...
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Fe3O4@SiO2-APA-Amide/Imid-CuCl2 nanocomposite as an efficient and reusable nanocatalyst for ecofriendly synthesis of 1,2,3-triazole derivatives
In this methodology, a nanomagnetic copper catalyst prepared via the immobilization of CuCl 2 on the surface of Fe 3 O 4 @SiO 2 -APA-Amide/Imid ligand and...
