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“Molecular Anatomy”: a new multi-dimensional hierarchical scaffold analysis tool
The scaffold representation is widely employed to classify bioactive compounds on the basis of common core structures or correlate compound classes...
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Scaffold Hop** and Screening for Potent Small Molecule Agonists for GRP94: Implications to Alleviate ER Stress-Associated Pathogenesis
Disparity in the activity of Endoplasmic reticulum (ER) leads to degenerative diseases, mainly associated with protein misfolding and aggregation...
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High Yield Fermentation of L-serine in Recombinant Escherichia coli via Co-localization of SerB and EamA through Protein Scaffold
L-serine is a non-essential amino acid which has a wide range of applications and plays an important role as a building block for growing cells....
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Enhanced Silk Fibroin-Based Film Scaffold Using Curcumin for Corneal Endothelial Cell Regeneration
The high demand for transplantable corneas is unlikely to subside anytime soon as there is a persistent shortage of cadaveric cornea. The goal of...
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Chitosan-incorporated poly(hydroxybutyrate) porous electrospun scaffold for potential biomedical applications
Herein, we report the fabrication of bio-based poly(hydroxybutyrate) (PHB)/chitosan blend electrospun fibers followed by surface chemical and...
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An Overview of Collagen-Based Composite Scaffold for Bone Tissue Engineering
Bone regeneration or restoration is a series of well-ordered physiological activities that occur throughout a person’s life, they are continuously...
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A novel hierarchical biofunctionalized 3D-printed porous Ti6Al4V scaffold with enhanced osteoporotic osseointegration through osteoimmunomodulation
BackgroundFemoral stem of titanium alloy has been widely used for hip arthroplasty with considerable efficacy; however, the application of this...
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Microarchitectural Silk Fibroin/Hyaluronic Acid Scaffold via Slight Biodegradation
Silk-based scaffolds with hierarchical structure possess the capacities of promoting cells adhesion, proliferation and neotissue formation, which...
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Fabrication and optimization of bioactive cylindrical scaffold prepared by electrospinning for vascular tissue engineering
Vascular regeneration is strictly depended on the proliferation and spreading of the injured endothelial cell layer especially in the small diameter...
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An in situ tissue engineering scaffold with growth factors combining angiogenesis and osteoimmunomodulatory functions for advanced periodontal bone regeneration
BackgroundThe regeneration of periodontal bone defect remains a vital clinical challenge. To date, numerous biomaterials have been applied in this...
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Biomimetic Boundary-Based Scaffold Design for Tissue Engineering Applications
The design of optimized scaffolds for tissue engineering and regenerative medicine is a key topic of current research, as the complex macro- and...
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Dendrimer-Functionalized Metal Oxide Nanoparticle-Mediated Self-Assembled Collagen Scaffold for Skin Regenerative Application: Function of Metal in Metal Oxides
Functionalized metal oxide nanoparticles cross-linked collagen scaffolds are widely used in skin regenerative applications because of their enhanced...
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In Vitro Study of Biocompatible Hybrid Scaffold of Polyvinyl Alcohol–Polyaniline–Nanocellulose for Tissue Engineering Applications
The development of tissue engineering techniques depends on scaffolds that combine the benefits of natural and synthetic biopolymers, which are both...
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Nano-fluorcanasite-fluorapatite Reinforced Poly-ε-caprolactone Based Biomimetic Scaffold: A Synergistic Approach Towards Generation of Conducive Environment for Cell Survival
This paper reports the development of bioactive fluorcanasite-fluorapatite nanoparticle (nFC-FAp) reinforced poly-(ε-caprolactone) (PCL)...
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Synthesis, Antifungal Activity, and QSAR Studies of Benzbutyrolactone Derivatives Based on α-Methylene-γ-butyrolactone Scaffold
Abstractα-Methylene-γ-butyrolactone scaffold and benzofuran pharmacophore demonstrate a number of valuable medicinal properties. Based on...
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Culture and in situ H2O2-mediated electrochemical study of cancer cells using three-dimensional scaffold based on graphene foam coated with Fe3O4 nanozyme
For real-time evaluation of the cell behavior and function under in vivo-like 3D environment, the 3D functionalized scaffolds simultaneously...
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Nitrogen-Doped Buckybowls as Potential Scaffold Material for Lithium-Sulfur Battery: A DFT Study
Using density functional theory calculations, we have investigated the influence of nitrogen do** in buckybowls on lithium polysulfide adsorption....
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Crosslinked oxidized-nanocellulose/chitosan hydrogels as a scaffold matrix for mesenchymal stem cell growth
Mesenchymal stem cells (MSC) are recognized for their immunomodulatory effects and regenerative properties, being promising therapeutic agents for a...
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Nanofiber Configuration of Electrospun Scaffolds Dictating Cell Behaviors and Cell-scaffold Interactions
E lectrospun nanofibers are of the same length scale as the native extracellular matrix and have been extensively reported to facilitate adhesion and...