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A Facile Route to Functionalized Cyclopenta[b]thiophenones Based on the Structure of the Selective COX-2 Inhibitor Flosulide
The synthesis of three thiophene analogues of Flosulide – a potent and selective inhibitor of cyclooxygenase subtype 2 (COX-2) – is described....
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Molecular properties of voltage-gated K+ channels
Subfamilies of voltage-activated K + channels (Kv1-4) contribute to controlling neuron excitability and the underlying functional parameters. Genes...
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Chemical fractionation in the solar system
The cosmochemical and geochemical history of planetary material is reflected in relative and absolute abundances of two groups of trace elements;...