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The advances in nanomedicine for bone and cartilage repair
With the gradual demographic shift toward an aging and obese society, an increasing number of patients are suffering from bone and cartilage...
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Cell-Derived Extracellular Vesicles for Tissue Engineering and Regenerative Medicine
Extracellular vesicles (EVs), lipid nanoparticles which contain functional cargo and are derived from cells, have the potential to regulate...
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Artificial Exosomes as Targeted Drug Delivery Systems
Exosomes are biological extracellular vesicles that are released by both prokaryotic and eukaryotic cells. Their size ranges between 40 and 160 nm,...
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Brain-targeted drug delivery - nanovesicles directed to specific brain cells by brain-targeting ligands
Neurodegenerative diseases are characterized by extensive loss of function or death of brain cells, hampering the life quality of patients....
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Co-delivery of Anticancer Drugs Using Polymer-Based Nanomedicines for Lung and Prostate Cancer Therapy
Although there are many treatment advances in oncology, cancer remains the cause of morbidity and mortality worldwide. The most common cancer types...
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Exosomes target HBV-host interactions to remodel the hepatic immune microenvironment
Chronic hepatitis B poses a significant global burden, modulating immune cells, leading to chronic inflammation and long-term damage. Due to its...
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Diagnosis and treatment status of inoperable locally advanced breast cancer and the application value of inorganic nanomaterials
Locally advanced breast cancer (LABC) is a heterogeneous group of breast cancer that accounts for 10–30% of breast cancer cases. Despite the ongoing...
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Ratiometric electrochemical OR gate assay for NSCLC-derived exosomes
Non-small cell lung cancer (NSCLC) is the most common pathological type of LC and ranks as the leading cause of cancer deaths. Circulating exosomes...
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Sensitive and specific detection of saccharide species based on fluorescence: update from 2016
Increasing evidence supports the critical role of saccharides in various pathophysiological steps of tumor progression, where they regulate tumor...
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Selective profiling of liver-related specific proteins based on sofosbuvir-modified magnetic separation material
It has great significance in profiling specific proteins throughout for better understanding of complex pathological processes and in-depth...
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Probing milk extracellular vesicles for intestinal delivery of RNA therapies
BackgroundOral delivery remains unattainable for nucleic acid therapies. Many nanoparticle-based drug delivery systems have been investigated for...
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CRISPR/Cas9 Nano-delivery Approaches for Targeted Gene Therapy
Gene-/genome-editing technology achieved its pinnacle of success in its therapeutic applications with the discovery of the CRISPR/Cas9 system. The...
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Fe3O4@SiO2-Protein A-oHSV/CD63 Ab for Capturing Virus and Exosomes
Protein A modified magnetic spheres (Fe 3 O 4 @SiO 2 -Protein A) with 22.7 emu/g saturation magnetization were prepared and characterized. These spheres...
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Biobased Nanomaterials in Nutraceuticals
Research has yet to demonstrate the biobased materials’ significant contribution as a renewable, limitless source of natural constituents required...
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Perspectives and trends in advanced optical and electrochemical biosensors based on engineered peptides
With the advancement of life medicine, in vitro diagnostics (IVD) technology has become an auxiliary tool for early diagnosis of diseases. However,...
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Nanobiodevice for Nucleic Acid Sensing
Nanobiodevices, a technology characterized by engineered nanostructures, have attracted extensive interest as a new generation bioanalytical tool...
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Nickel-Doped Microfluidic Chip for Rapid and Efficient Immunomagnetic Separation and Detection of Breast Cancer Cell-Derived Exosomes
Breast cancer cell-derived exosomes have high potential as biomarkers for continuous biopsies and longitudinal monitoring in breast cancer. However,...
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Non-stem cell-derived exosomes: a novel therapeutics for neurotrauma
Neurotrauma, encompassing traumatic brain injuries (TBI) and spinal cord injuries (SCI) impacts a significant portion of the global population. While...
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Cell unit-inspired natural nano-based biomaterials as versatile building blocks for bone/cartilage regeneration
The regeneration of weight-bearing bone defects and critical-sized cartilage defects remains a significant challenge. A wide range of...
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Protein overproduction alters exosome secretion in Chinese hamster ovary cells
Despite the abundance of available cell lines, nearly 70% of all recombinant therapeutic proteins today are produced in Chinese hamster ovary (CHO)...
