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Curtius Rearrangement
Alkyl-, vinyl-, and aryl-substituted acyl azides undergo thermal 1,2-carbon-to-nitrogen migration with extrusion of dinitrogen — the Curtius...
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Synthesis of New Thieno[2,3-d]pyrimidines Containing a 1,2,3-Triazole Ring and Their Therapeutic Response in NCI-60 Cell Line Panel
AbstractA series of new tetrahydro[1]benzothieno[2,3- d ]pyrimidines containing a 1,2,3-triazole fragment linked through an oxymethylene spacer...
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Uncatalyzed gas phase aziridination of alkenes by organic azides. Part 2. Whole azide reaction with alkene
AbstractThe B3LYP/6-31G(d,p) DFT method was used to study alkene aziridination by azides through uncatalyzed thermal gas phase routes which involve...
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Synthesis of Novel Azides and Triazoles on the Basis of 1н-Pyrazole-3(5)-Carboxylic Acids
The goal of this work was to obtain novel ligands basedis on 1 H -pyrazole-3(5)-carboxylic acids containing the triazole moiety at positions 3(6) or 4....
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Design, synthesis, and activity of 2-aminochromone core N,N-bis-1,2,3-triazole derivatives using click chemistry
A new series of 2-aminochromone-based N,N -di-1,2,3-triazole hybrid heterocycles were synthesized in one pot from N,N -terminal dialkyne...
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The use of silyl groups in the synthesis of arabinofuranosides
The review considers the known strategies for the synthesis of fragments of arabinogalactan and lipoarabinomannan, polysaccharides that are contained...
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Regioselective synthesis and DFT computational studies of novel β-hydroxy-1,4-disubstituted-1,2,3-triazole-based benzodiazepinediones using click cycloaddition reaction
Novel β-hydroxy-1,4-disubstituted-1,2,3-triazole-based benzodiazepinedione derivatives were synthesized by a regioselective cascade reaction and were...
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An Overview of N-Heterocycle Syntheses Involving Nitrene Transfer Reactions
The addition of either free or transition metal-supported nitrenes to unsaturated C–C bonds and heteroatom lone pairs, as well as intramolecular...
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Synthesis and Anticancer Activity of 11-azaartemisinin Derivatives Bearing 1,2,3-triazole Moiety
A series of new compounds were prepared under mild reaction conditions using click reaction of 11-azaartemisinin and various azides. All the...
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Direct Synthesis and Anticancer Properties of Novel Piperazine-Linked Homobivalent Tetrazole-5-thione Derivatives
AbstractA novel series of homobivalent 1,4-disubstituted tetrazole-5-thiones with piperazine moiety as a linker group were synthesized and evaluated...
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Mutually Orthogonal Bioorthogonal Reactions: Selective Chemistries for Labeling Multiple Biomolecules Simultaneously
Bioorthogonal click chemistry has played a transformative role in many research fields, including chemistry, biology, and medicine. Click reactions...
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Microwave-assisted one-pot quick synthesis of 1-monosubstituted 1,2,3-triazoles from arylboronic acids, sodium azide and 3-butyn-2-ols
AbstractMicrowave-assisted one-pot quick synthesis to 1-monosubstituted 1,2,3-triazoles was achieved with good to excellent yields using the widely...
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The Chemistry of 2-(1H)-Pyrazinones in Solution and on Solid Support
An overview on the microwave-enhanced synthesis and decoration of the 2(1H)-pyrazinone system is presented. Scaffold decoration using...
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Computational Organic Chemistry: The Frontier for Understanding and Designing Bioorthogonal Cycloadditions
Computational organic chemistry has become a valuable tool in the field of bioorthogonal chemistry, offering insights and aiding in the progression...
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Chan–Lam C–X Coupling Reaction
Arylation, vinylation and alkylation of a wide range of NH/OH/SH substrates by oxidative cross-coupling with boronic acids in the presence of...
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Chalcogenocarboxylic Acids
Although thio- and dithio-carboxylic acids have been extensively studied for some time now, research into other chalcogenocarboxylic acids –...
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Click to learn, learn to click: undergraduate synthetic organic chemistry experiments
The optimization of an undergraduate experiment for Organic Chemistry students is described to explore the concept of click chemistry. The...
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Synthesis of 2-aminophenoxazin-3-ones by photolysis of 2-azidophenol and 2-aminophenols
The synthetic method of 2-amino-3 H -phenoxazin-3-one derivatives through the photoinitiated cyclocondensation of 2-azidophenol with substituted...
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Synthesis of Tetrazole Derivatives
AbstractThe present review focuses on the versatile synthesis of tetrazole derivatives. The tetrazole ring system has attracted much attention in...
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New bifunctional amphiphilic oxyethylimidazolium derivatives of calix[4]arene containing alkynyl/azide fragments: regularities of aggregation and polymerization under azide/alkyne cycloaddition conditions
New bifunctional amphiphilic oxyethylimidazolium derivatives of calix[4]arene with terminal alkynyl or azide fragments in the polar moiety of the...