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Infectivity of adeno-associated virus serotypes in mouse testis
BackgroundRecombinant adeno-associated viruses (AAVs) are emerging as favoured transgene delivery vectors for both research applications and gene...
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Efficient gene transfer into T lymphocytes by fiber-modified human adenovirus 5
BackgroundThe gene transduction efficiency of adenovirus to hematopoietic cells, especially T lymphocytes, is needed to be improved. The purpose of...
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IFITM3 directly engages and shuttles incoming virus particles to lysosomes
Interferon-induced transmembrane proteins (IFITMs 1, 2 and 3) have emerged as important innate immune effectors that prevent diverse virus infections...
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Naturally Occurring Organohalogen Compounds—A Comprehensive Review
The present volume is the third in a trilogy that documents naturally occurring organohalogen compounds, bringing the total number—from fewer than 25...
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CRISPR–Cas9 System for Genome Engineering of Photosynthetic Microalgae
Targeted genome editing using RNA-guided endonucleases is an emerging tool in algal biotechnology. Recently, CRISPR–Cas systems have been widely used...
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Formation of the layer of influenza A virus M1 matrix protein on lipid membranes at pH 7.0
The kinetics of interaction of influenza A virus M1 matrix protein with hydrophilic polymer-supported lipid bilayers formed by 1,2-diphytanoyl- sn -glyc...
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Gene Therapy
Gene therapy medicinal products (GTMPs) are one of the most promising biopharmaceuticals, which are beginning to show encouraging results. The broad...
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Propagation and Isolation of Tobacco Mosaic Virus That Surface Displays Metal Binding and Reducing Peptides for Generation of Gold Nanoparticles
In this chapter we describe an approach for propagating, isolating and characterizing tobacco mosaic virus (TMV) genetically modified to surface...
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Bioinspired recognition elements for mycotoxin sensors
Mycotoxins are low molecular weight molecules produced as secondary metabolites by filamentous fungi that can be found as natural contaminants in...
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History of Polymeric Gene Delivery Systems
As an option for genetic disease treatment and an alternative for traditional cancer chemotherapy, gene therapy achieves significant attention....
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Virus-Like Particles Derived from HIV-1 for Delivery of Nuclear Proteins: Improvement of Production and Activity by Protein Engineering
Virus-like particles (VLPs) derived from retroviruses and lentiviruses can be used to deliver recombinant proteins without the fear of causing...
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History of Polymeric Gene Delivery Systems
As an option for genetic disease treatment and an alternative for traditional cancer chemotherapy, gene therapy achieves significant attention....
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Applications of Glycosaminoglycans in the Medical, Veterinary, Pharmaceutical, and Cosmetic Fields
Glycosaminoglycans (GAGs) are complex polysaccharides ubiquitously present in the extracellular matrix of mammalian tissues, where they constitute...
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Inhibition of Respiratory Syncytial Virus Replication by Simultaneous Targeting of mRNA and Genomic RNA Using Dual-Targeting siRNAs
We attempted to generate siRNAs with two active strands, which can simultaneously knock down the expression of mRNA and viral genomic RNA. In this...
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Natural Food Antimicrobials of Animal Origin
Various compounds found in animals possess antimicrobial activity (Board, New methods of food preservation, Springer, New York, 1995; Phoenix et al.,...
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Recent Advances in Develo** Antiviral Therapies for Respiratory Syncytial Virus
Respiratory syncytial virus (RSV) infection presents a significant health challenge in small children, the elderly and immunocompromised patients....
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Stimuli-Responsive Polymeric Nanocarriers for Efficient Gene Delivery
Gene therapy provides an alternative and effective method for treatment of genetic diseases and cancers that are refractory to conventional...
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Downstream Processing Technologies/Capturing and Final Purification
Increased pressure on upstream processes to maximize productivity has been crowned with great success, although at the cost of shifting the...
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Tritium planigraphy and nanosized biological particles
Advances in studies of protein and complex biological systems by tritium planigraphy are considered. Particular attention is paid to detailing the...
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Anti-HIV Agents: Current Status and Recent Trends
Human immunodeficiency virus is responsible for acquired immunodeficiency syndrome (AIDS), an infectious disease that consists a serious concern...