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Preclinical In Vivo Drug Development Studies: Limitations, Model Organisms, and Techniques
The process of drug discovery and development encompasses target identification, validation, assay development, identification of hits, lead...
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Cyanidin: Advances on Resources, Biosynthetic Pathway, Bioavailability, Bioactivity, and Pharmacology
Anthocyanins are naturally occuring pigements belongs to the group of flavinoids, a sub class of polyphenol familly. Cyanidin (Velderrain-Rodríguez...
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Introduction
PolymersPolymers have evolved through an intricate and fascinating history by mankind’s imagination and inventiveness. These materials encompassed...
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High-Throughput Comprehensive Quantitative LC-MS/MS Analysis of Common Drugs and Metabolites (62 Compounds) in Human Urine
In recent years a multitude of LC-MS/MS assays have been widely reported in commercial and clinical literature demonstrating the simultaneous...
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An Overview of National Toxicology Program’s Toxicogenomic Applications: DrugMatrix and ToxFX
DrugMatrixDrugMatrix and its automated toxicogenomicsToxicogenomics reporting system, ToxFXToxFX are the scientific communities’ largest...
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In Vitro Methodologies for the Safety Assessment of Drugs
Since ages, drugs have been used in some form or the other for treatment of several diseases. Safety assessment of drug is an important step required...
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A simplified approach for determination of urinary ethyl glucuronide by gas chromatography–mass spectrometry
Urinary ethyl glucuronide (EtG), an alcohol biomarker, plays an essential role in monitoring alcohol abstinence and relapse during treatment for...
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Analysis of Barbiturates in Urine by LC-MS/MS
In the method described here, an aliquot of a urine sample is analyzed to detect barbiturates through dilution and ultra-high-performance...
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Toxicology of Starch-Based DDSs
Because of its natural source and high biocompatibility, starch has drawn much attention in the advance of drug delivery systems (DDSs) as carrier...
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Quantitative LC-MS/MS Analysis of Amphetamines and Cocaine in Human Urine
We hereby present a fast and high-throughput LC-MS/MS assay for the simultaneous analysis of amphetamines and cocaine in human urine. The assay is...
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Quantitative LC-MS/MS Analysis of Opiates and Opioids in Human Urine
We hereby present a direct, clinical LC-MS/MS assay for the simultaneous analysis of opiates and opioids in human urine. The assay is used as...
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Opportunities and Challenges in Biomedical Applications of Metal–Organic Frameworks
AbstractUnique chemical and physical properties of metal–organic framework (MOF) nanoparticles suggest them as promising candidates for various...
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Isorhamnetin: Current knowledge and potential benefits for disease management
Isorhamnetin is a flavonol that naturally occurs in a variety of plants and is also present in several plant-derived foodstuffs and beverages,...
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Nano-Informatics: Studies on Nano Information Platforms and Their Application in Various Sectors
Nano-informatics is the interdisciplinary area that investigates the application of information technology on nanobiotechnological data. It is...
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Analysis of Endogenous Metabolites in Human Matrices
For several decades, biological matrices have been used to assess the physiological conditions of organisms. The development of analytical techniques...
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Nonclinical Safety Testing of RNA Vaccines
In this chapter, we will first consider the overall goal of nonclinical safety testing during drug development and have a brief overview of its...
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Analysis of Endogenous Metabolites in Human Matrices
For several decades, biological matrices have been used to assess the physiological conditions of organisms. The development of analytical techniques...
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Genetically Engineered Human Kidney Cells for Real-Time Cytotoxicity Testing In Vitro
Classic toxicology studies often utilize in vivo animal models. Newer approaches employing in vitro organ-specific cellular models have been...
