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Biosynthesis of Zinc Oxide Nanoparticles Using Bacillus paramycoides for In Vitro Biological Activities and In Vivo Assessment Against Hepatorenal Injury Induced by CCl4 in Rats
Recently, impressive developments in the field of nanotechnology have been achieved. The study aimed to synthetize zinc oxide nanoparticles (ZnONPs)...
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In vivo toxicity evaluation of tumor targeted glycol chitosan nanoparticles in healthy mice: repeated high-dose of glycol chitosan nanoparticles potentially induce cardiotoxicity
BackgroundGlycol chitosan nanoparticles (CNPs) have emerged as an effective drug delivery system for cancer diagnosis and treatment. Although they...
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Preliminary evaluation and in vitro cytotoxicity studies of [131I]I-trastuzumab in HER2 expressing ovarian cancer cells
As trastuzumab is known to target the human epidermal growth factor receptor type (HER2), the potential of [ 131 I]I-trastuzumab as a...
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Experimental and theoretical investigation on structure, toxicity, and DNA interaction of turmeric-coated cobalt ferrite nanocomposites
A comprehensive investigation was performed on the structural, toxicity, and DNA interaction of the co-precipitated turmeric@CoFe 2 O 4 nanoparticles...
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Development of novel thiazole-based hybrids as DNA gyrase inhibitors: design, synthesis, in silico and in vitro antibacterial evaluation
Novel thiazole-based hybrids (8a–g) and (9a–g) were developed and synthesized to create lead compounds with remarkable antibacterial efficacy....
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Unveiling the silver lining: examining the effects of biogenic silver nanoparticles on the growth dynamics of in vitro olive shoots
The current study aimed to evaluate the effects of biogenic silver nanoparticles (AgNPs) on growth behavior and leaf anatomy of in vitro growing...
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Colchicine-mediated in vitro polyploidization in gerbera hybrid
An efficient in vitro protocol for high-frequency polyploidization for the first time in gerbera hybrid (BGC-2019-01) was developed in the present...
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Synthesis and Characterization of Plumbagin S-Allyl Cysteine Ester: Determination of Anticancer Activity In Silico and In Vitro
In recent years, derivatives of natural compounds are synthesized to increase the bioavailability, pharmacology, and pharmacokinetics properties. The...
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Prevention of aspirin-mediated secondary toxicity by combined treatment of carotenoids in macrophages
Upon understanding the boosting role of carotenoids on the endogenous anti-inflammatory system, it is vital to explore their role in reducing the use...
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Carmustine-Loaded Liposomal Delivery Effectively Targets Malignant Glioma Cells and Seizes Endothelial Sprouting In vitro
The delivery of chemotherapeutics through the blood-brain barrier remains a challenge for glioblastoma therapeutics. The overdosage of these agents...
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In Vitro Models of CNS Barriers
In vitro models of the blood-brain barrier provide valuable mechanistic information and useful assay systems for drug discovery and delivery....
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In vitro activity of novel 4-iminohydantoin sulfamide derivatives against human cytomegalovirus
Here, we describe machine learning models, predicted ADMET properties, and analysis in vitro activity of selected 4-iminohydantoin sulfamide...
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Investigating the Molecular Interactions of Quinoline Derivatives for Antibacterial Activity Against Bacillus subtilis: Computational Biology and In Vitro Study Interpretations
Bacterial infections are evolving and one of the chief problems is emergence and prevalence of antibacterial resistance. Moreover, certain strains of B...
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The potential modulatory impact of garlic-selenium nanoparticles coated with synthetic tocopherol polyethylene glycol-succinate against lead acetate toxicity in male rabbits
Toxic heavy metal lead enters in the environment due to industrial and anthropogenic activity threatens ecosystems and public health. Natural garlic...
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Initiation of Apoptotic Pathway by the Cell-Free Supernatant Synthesized from Weissella cibaria Through In-Silico and In-Vitro Methods
Globally, colorectal cancer is the most prevalent type of cancer. Even though multiple treatments such as surgery, radiation, chemotherapy, and...
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In-vitro and in-vivo assessment of Polycaprolactone-Chitosan-Pectin imbibed nanofiber potentials as a wound healing biomaterial
The goal of the current study was to evaluate the wound healing potential of electrospun Polycaprolactone—Chitosan—Pectin (PCL-CS-PEC composite...
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Toxicity, Pharmacokinetic Profile, and Compound-Protein Interaction Study of Polygonum minus Huds Extract
Several phytochemicals with potential for bioactivity can be found in Polygonum minus (PM). The goal of this investigation was to establish the...
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Nano-Resveratrol Liposome: Physicochemical Stability, In Vitro Release, and Cytotoxicity
Nano-resveratrol liposome (RES-LIP) was prepared by the thin film rotary-evaporated method combined with ultrasonication and characterized by...
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Defensive Impact of Kaempferide Against Neurodegenerative Studies: In Vitro and In Vivo Investigations
BackgroundPrevious studies show evidence that brain aging is mainly due to oxidative stress, mitochondrial damage, and apoptosis. In this study, we...
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Biosynthesis of Iron Oxide Nanoparticles (IONPs): Toxicity Evaluation and Applications for Magnetic Resonance Imaging and Magnetic Hyperthermia
The production of green metal oxide nanoparticles has garnered considerable interest. The use of a magnetic field to separate iron oxide...