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Aptamers for Targeted Therapy
This chapter introduces the aptamers for targeted therapy. Aptamers show promising efficacy and safety in four types of clinical studies of...
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Pectin-like polysaccharide extracted from leaves Crataeva tapia promotes antioxidant, immunomodulatory and emulsifiers applied in therapeutic formulations
The objective of this work was to isolate a polysaccharide similar to pectin from Crataeva tapia leaves, not yet reported in the literature, and to...
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Integrative overview of antibodies against SARS-CoV-2 and their possible applications in COVID-19 prophylaxis and treatment
SARS-CoV-2 is a novel β-coronavirus that caused the COVID-19 pandemic disease, which spread rapidly, infecting more than 134 million people, and...
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Adjuvants for cancer mRNA vaccines in the era of nanotechnology: strategies, applications, and future directions
Research into mRNA vaccines is advancing rapidly, with proven efficacy against coronavirus disease 2019 and promising therapeutic potential against a...
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The roles of catechins in regulation of systemic inflammation
Catechins are a phytochemical present in plants such as tea leaves, beans, black grapes, cherries, and cacao, and have various physiological...
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Polymeric nanomedicines for the treatment of hepatic diseases
The liver is an important organ in the human body and performs many functions, such as digestion, detoxification, metabolism, immune responses, and...
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Exosomes for mRNA delivery: a novel biotherapeutic strategy with hurdles and hope
Over the past decade, therapeutic messenger RNAs (mRNAs) have emerged as a highly promising new class of drugs for protein replacement therapies. Due...
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Elimination of N-glycosylation by site mutation further prolongs the half-life of IFN-α/Fc fusion proteins expressed in Pichia pastoris
BackgroundInterferon (IFN)-α has been commonly used as an antiviral drug worldwide; however, its short half-life in circulation due to its low...
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Die Abwehrreaktion des angeborenen Immunsystems: Einflüsse von Lebensmittelkomponenten auf die frühe Phase der Immunantwort
Das Komplementsystem ist eine proteolytische Aktivierungskaskade mit vielfältigen, antimikrobiellen und immunregulativen Proteinelementen. Es stellt...
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Preclinical Evaluation of virus-like particle Vaccine Against Carbonic Anhydrase IX Efficacy in a Mouse Breast Cancer Model System
Carbonic anhydrase IX (CAIX) is a cancer-associated membrane protein frequently overexpressed in hypoxic solid tumours leading to enhanced tumour...
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Cocktail strategy based on a dual function nanoparticle and immune activator for effective tumor suppressive
BackgroundImmune checkpoint inhibitor-mediated immunotherapy cannot be carried out on a large scale clinically due to its low universality. In recent...
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An NK cell line (NK92-41BB) expressing high levels of granzyme is engineered to express the high affinity chimeric genes CD16/CAR
Natural killer (NK) cells are known to play a role in mediating innate immunity and have been implicated in mediating anti-tumor responses via...
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The effects of long-term moderate exercise and Western-type diet on oxidative/nitrosative stress, serum lipids and cytokines in female Sprague Dawley rats
PurposeRegular exercise reduces obesity and the risk of cardiovascular disease. However, health-promoting benefits of physical activity are commonly...
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An Overview of Veterinary Viral Diseases and Vaccine Technologies
Ensuring the maximum standards of quality and welfare in animal production requires develo** effective tools to halt and prevent the spread of the...
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Biomaterials as Antigen Delivery Carrier for Cancer Immunotherapy
Since immunotherapy provides an opportunity to treat metastatic and disseminated tumors, it has become a major treatment strategy for cancer....
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Acute pharmacological degradation of Helios destabilizes regulatory T cells
The zinc-finger transcription factor Helios is critical for maintaining the identity, anergic phenotype and suppressive activity of regulatory T (T reg ...
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Aptamer Molecular Evolution for Liquid Biopsy
Liquid biopsy can provide comprehensive and real-time physiological and pathological information in a noninvasive and longitudinal monitoring manner,...
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Generation of oligomers of subunit vaccine candidate glycoprotein D of Herpes Simplex Virus-2 expressed in fusion with IgM Fc domain(s) in Escherichia coli: A strategy to enhance the immunogenicity of the antigen
Glycoprotein D (gD) of Herpes Simplex Virus-2 is used as an antigen in various anti-herpes subunit vaccines owing to its involvement in binding the...
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Irradiated microparticles suppress prostate cancer by tumor microenvironment reprogramming and ferroptosis
Immunogenic cell death (ICD) plays a crucial role in triggering the antitumor immune response in the tumor microenvironment (TME). Recently,...
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Aptamer Molecular Evolution for Liquid Biopsy
Liquid biopsy can provide comprehensive and real-time physiological and pathological information in a noninvasive and longitudinal monitoring manner,...