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Nanomaterials-Based (Bio)Sensing Systems for Safety and Security Applications
The development of new nanomaterials and nanotechnologies has provided many new opportunities for (bio)sensing systems. The introduction of...
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Direct immobilization of DNA probes on non-modified plastics by UV irradiation and integration in microfluidic devices for rapid bioassay
DNA microarrays have become one of the most powerful tools in the field of genomics and medical diagnosis. Recently, there has been increased...
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Nanomicrobiology
Microbiology plays an important role in practice of medicine. Nanodiagnostics have refined the detection of infectious diseases and many new...
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Synthesis of 1,3-dialkyl-5-(hetaryl-1-yl)-1,3-dihydrobenzimidazol-2-ones
Reactions of 5-amino-1,3-dialkyl-1,3-dihydrobenzimidazol-2-ones with 2,5-dimethoxytetrahydrofuran and 2,6-dimethyl-γ-pyranone led to the formation of...
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Multifunctional nanoparticles as simulants for a gravimetric immunoassay
Immunoassays are important tools for the rapid detection and identification of pathogens, both clinically and in the research laboratory. An...
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Identification of ligand binding site on RXRγ using molecular docking and dynamics methods
Retinoid X receptors (RXRα, β and γ) are recently known to be cancer chemotherapies targets. The ligand binding domains of RXRs have been...
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Molecular insights into human receptor binding to 2009 H1N1 influenza A hemagglutinin
AbstractThe current pandemic of the viral 2009 H1N1 influenza and its sustained human–human transmission has raised global concern for human health....
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Development of Real Time RT-PCR Assays for Detection of Type A Influenza Virus and for Subty** of Avian H5 and H7 Hemagglutinin Subtypes
Rapid detection and subty** of H5 and H7 subtypes influenza A viruses are important for disease control in poultry and potential transmission to...
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Multiplexed, rapid detection of H5N1 using a PCR-free nanoparticle-based genomic microarray assay
BackgroundFor more than a decade there has been increasing interest in the use of nanotechnology and microarray platforms for diagnostic...
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Synthesis of morphinans with diversely functionalized benzoxazole moieties
AbstractThree independent strategies have been established for the synthesis of morphinans with oxazole moieties derived from the aminophenol...
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Development and application of lateral flow test strip technology for detection of infectious agents and chemical contaminants: a review
Recent progress in the laboratory has been a result of improvements in rapid analytical techniques. An update of the applications of lateral flow...
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Genoty** Arrays
Although the most common use of DNA microarrays is gene expression profiling, microarrays are also used for many other applications, including...
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Molecular modeling study on chemically diverse series of cyclooxygenase-2 selective inhibitors: generation of predictive pharmacophore model using Catalyst
Cyclooxygenase (COX) enzymes catalyse the biosynthesis of prostaglandins and thromboxane from arachidonic acid (AA). We summarize in this paper, the...
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Detection of avian influenza virus using an interferometric biosensor
An interferometric biosensor immunoassay for direct and label-less detection of avian influenza through whole virus capture on a planar optical...
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Model of the whole rat AT1 receptor and the ligand-binding site
We present a three-dimensional model of the rat type 1 receptor (AT 1 ) for the hormone angiotensin II (Ang II). Ang II and the AT 1 receptor play a...
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Comparative analysis of different competitive antagonists interaction with NR2A and NR2B subunits of N-methyl-D-aspartate (NMDA) ionotropic glutamate receptor
The antagonist-bound conformation of the NR2A and NR2B subunits of N -methyl- D -aspartate (NMDA) ionotropic glutamate receptor are modeled using the...
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Viruses and Some Other Proven and Suspected Foodborne Biohazards
Much less is known about the incidence of viruses in foods than about bacteria and fungi, for several reasons. First, being obligate parasites,...
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Multiple Biochemical Activities of NM23/NDP Kinase in Gene Regulation
NM23/NDPk proteins play critical roles in cancer and development; however, our understanding of the underlying biochemical mechanisms is still...
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Structural Features of ATPA and Thio-ATPA—Potent and Selective GluR5 Receptor Agonists. Crystal Structure Determinations and Quantum Chemical Calculations
ATPA and thio-ATPA are semirigid analogs of the excitatory neurotransmitter ( S )-glutamic acid. ( S )-ATPA and ( S )-thio-ATPA are potent and selective...