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Resveratrol inhibits TRAF6/PTCH/SMO signal and regulates prostate cancer progression
Prostate cancer (PC) is one of the most common types of cancers among men, referring to the uncontrolled growth of the prostate gland. It is...
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Rapid and visual detection of viable Staphylococcus aureus in pork and pork products by PMA and saltatory rolling circle amplification
The aim of this study was to establish a rapid and visual nucleic acid isothermal amplification method for the detection of viable Staphylococcus...
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Analysis and validation of silica-immobilised BST polymerase in loop-mediated isothermal amplification (LAMP) for malaria diagnosis
Bacillus stearothermophilus large fragment (BST LF ) DNA polymerase is reported, isolated on silica via a fused R5 silica-affinity peptide and used in...
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Colorectal cancer tumor stem cells mediate bevacizumab resistance through the signal IL-22-STAT3 signaling pathway
Bevacizumab is the standard treatment for colorectal cancer (CRC) in the advanced stage. However, poor diagnosis identified due to the bevacizumab...
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Paedoksan ameliorates allergic disease through inhibition of the phosphorylation of STAT6 in DNCB-induced atopic dermatitis like mice
Various allergic diseases such as atopic dermatitis (AD), allergic rhinitis, and asthma are considered incurable conditions that have yet to be fully...
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Vascular disrupting agent-induced amplification of tumor targeting and prodrug activation boosts anti-tumor efficacy
Vadimezan, one of the typical vascular disrupting agents (VDAs) currently in clinical trials, has been extensively implemented for cancer research,...
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Novel benzylidene benzofuranone analogues as potential anticancer agents: design, synthesis and in vitro evaluation based on CDK2 inhibition assays
The classical anticancer agents do not have their efficacy on inhibiting the G2 phase of the cell cycle. There are a very few reports available on...
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A novel electrochemical immunosensor for sensitive detection of depression marker Apo-A4 based on bipyridine-functionalized covalent organic frameworks
A novel electrochemical immunosensor for detecting potential depression biomarker Apolipoprotein A4 (Apo-A4) was developed using a multi-signal...
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A fluorescence signal amplification strategy for modification-free ratiometric determination of tyrosinase in situ based on the use of dual-templated copper nanoclusters
A fluorescence resonance energy transfer (FRET)-based in situ fluorescence signal amplification strategy is described for the determination of...
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Screening of miRNAs in plasma as a diagnostic biomarker for cardiac disease based on optimization of extraction and qRT-PCR condition assay through amplification efficiency
BackgroundAlthough quantitative real-time PCR (qRT-PCR) is a common and sensitive method for miRNAs analysis, it is necessary to optimize conditions...
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LED irradiation at 630 nm alleviates collagen-induced arthritis in mice by inhibition of NF-κB-mediated MMPs production
Matrix metallopreteinase (MMP), a family of matrix degrading enzyme, plays a significant role in persistent and irreversible joint damage in...
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A fluorometric assay for rapid enrichment and determination of bacteria by using zirconium-metal organic frameworks as both capture surface and signal amplification tag
A fluorometric assay was introduced to determine Acinetobacter baumannii ( A . baumannii ) in blood samples by utilizing Zr-MOFs both as functional...
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Signal-amplified electrochemiluminescence aptasensor for mucin 1 determination using CdS QDs/g-C3N4 and Au NPs@TEOA
A novel electrochemiluminescence (ECL) aptasensor, using graphite carbonitride (g-C 3 N 4 ) capped CdS quantum dots (CdS QDs@g-C 3 N 4 ) and Au nanoparticles...
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Efficient Inhibition of Bacterial Biofilm Through Interference of Protein–Protein Interaction of Master Regulator Proteins: a Proof of Concept Study with SinR- SinI Complex of Bacillus subtilis
Biofilm-associated microbial growth is a major cause of environmental, industrial, and public health concern. Therefore, there is a pressing need to...
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Allele-Specific Replication Inhibition of Mitochondrial DNA by MITO-PIP Conjugated with Alkylation Reagent
Pathogenic mutations in mitochondrial DNA cause genetic disorders named mitochondrial diseases. Although mutated mitochondrial DNA should be...
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Target-regulated photoactivities of CdS/Ni-MOF heterojunction with [Ru(bpy)2dppz]2+ intercalator: a bisphenol A photoelectrochemical aptasensor
Bisphenol A (BPA), an important endocrine disrupting compound, has infiltrated human daily lives through electronic devices, food containers, and...
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Ultrasensitive cloth-based microfluidic chemiluminescence detection of Listeria monocytogenes hlyA gene by hemin/G-quadruplex DNAzyme and hybridization chain reaction signal amplification
In this work, a cloth-based chemiluminescence (CL) biosensor has been firstly presented for highly sensitive determination of long PCR amplicons....
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Assay of Biomarkers for Alzheimer’s Disease by Surface Plasmon Resonance
Alzheimer’s disease (AD) is one of the neurodegenerative diseases characterized by cognitive dysfunction and behavioral impairment. Early diagnosis...
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High-performance green-emitting AIE nanoparticles for lateral flow immunoassay applications
Ultrabright green-emissive AIE nanoparticles (AIENPs) were used as signal-amplification probes to enhance the detectability of lateral flow...
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Hsa_circ_0001162 Inhibition Alleviates High Glucose-Induced Human Podocytes Injury by the miR-149-5p/MMP9 Signaling Pathway
Emerging evidences suggested that circular RNAs (circRNAs) are involved in diabetic nephropathy (DN). Accumulating evidence had suggested that the...
