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BCMA/CD47-directed universal CAR-T cells exhibit excellent antitumor activity in multiple myeloma
BackgroundBCMA-directed autologous chimeric antigen receptor T (CAR-T) cells have shown excellent clinical efficacy in relapsed or refractory...
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The 2018 Nobel Prize in Chemistry: phage display of peptides and antibodies
One-half of the 2018 Nobel Prize in Chemistry was awarded jointly to George P. Smith and Sir Gregory P. Winter “for the phage display of peptides and...
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Trends and Challenges in Enzyme Technology
Several major developments took place in the field of biocatalysis over the past few years. These include the invention of directed evolution...
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Motif-dependent binding on the intervening domain regulates O-GlcNAc transferase
The modification of intracellular proteins with O-linked β- N -acetylglucosamine (O-GlcNAc) moieties is a highly dynamic process that spatiotemporally...
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Affinity Peptide-based Electrochemical Biosensor for the Highly Sensitive Detection of Bovine Rotavirus
Bovine diarrhea is a major concern in the global bovine industry because it can cause significant financial damage. Of the many potential infectious...
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Phage Display Libraries: From Binders to Targeted Drug Delivery and Human Therapeutics
The application of repertoire selection technologies for the study and characterization of tumor heterogeneity is an area of great interest in the...
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Quantitative detection of urinary bladder cancer antigen via peptide-immobilized magnetic bead-based SERS probe
Antibody pairing is a difficult step in develo** all immune-sandwich assay for antigen detection. Urinary bladder cancer (UBC) antigen is a typical...
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Enhancing the Therapeutic Potential of Extracellular Vesicles Using Peptide Technology
Extracellular vesicles are lipid-bilayer-enclosed nanoparticles present in the majority of biological fluids that mediate intercellular...
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Isolation of Bacteriophages on Actinobacteria Hosts
Bacteriophages are ubiquitous biological entities which can be found in a variety of habitats. Here, we describe protocols for the isolation of...
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Extract-Shaped Immune Repertoires as Source for Nanobody-Based Human IgE in Grass Pollen Allergy
The presence of allergen-specific IgE in serum is a biomarker for allergic disease. Specific IgE antibodies for research and diagnostics, however,...
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A potent synthetic nanobody with broad-spectrum activity neutralizes SARS-CoV-2 virus and the Omicron variant BA.1 through a unique binding mode
The major challenge to controlling the COVID pandemic is the rapid mutation rate of the SARS-CoV-2 virus, leading to the escape of the protection of...
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Huc-MSC-derived exosomes modified with the targeting peptide of aHSCs for liver fibrosis therapy
BackgroundEffective therapeutics to stop or reverse liver fibrosis have not emerged, because these potential agents cannot specifically target...
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Genetically encoded multivalent liquid glycan array displayed on M13 bacteriophage
The central dogma of biology does not allow for the study of glycans using DNA sequencing. We report a liquid glycan array (LiGA) platform comprising...
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Evolution of Transgenic Technology: From Random Transgenesis to Precise Genome Editing
New techniques in molecular biology help us for better understanding of biological processes. As biologists we resort to powerful approaches for...
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Advances in the Production and Batch Reformatting of Phage Antibody Libraries
Phage display antibody libraries have proven an invaluable resource for the isolation of diagnostic and potentially therapeutic antibodies, the...
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Engineering integrative vectors based on phage site-specific recombination mechanism for Lactococcus lactis
BackgroundSite-specific integration system allows foreign DNA to be integrated into the specific site of the host genome, enabling stable expression...
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Production of a Ribosome-Displayed Mouse scFv Antibody Against CD133, Analysis of Its Molecular Docking, and Molecular Dynamic Simulations of Their Interactions
The pentaspan transmembrane glycoprotein CD133, prominin-1, is expressed in cancer stem cells in many tumors and is promising as a novel target for...
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Generation of bioluminescent enzyme immunoassay for ferritin by single-chain variable fragment and its NanoLuc luciferase fusion
Ferritin, widely present in liver and spleen tissue, is considered as a serological biomarker for liver diseases and cancers. The detection of...
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Rapid and Sensitive Detection of Staphylococcal Enterotoxin B by Recombinant Nanobody Using Phage Display Technology
Staphylococcal enterotoxin B, from Staphylococcus aureus ( S. aureus ), is one of the most potent bacterial superantigens with profound toxic effects...
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Development of nanobody-horseradish peroxidase-based sandwich ELISA to detect Salmonella Enteritidis in milk and in vivo colonization in chicken
BackgroundSalmonella Enteritidis ( S. Enteritidis ) being one of the most prevalent foodborne pathogens worldwide poses a serious threat to public...
