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Amine functionalization of cellulose nanocrystals for acid–base organocatalysis: surface chemistry, cross-linking, and solvent effects
Sulfuric acid-derived cellulose nanocrystals (CNCs) are investigated as an alternative support for bifunctional heterogeneous organocatalyst...
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Chiral Ureas and Thiroureas in Asymmetric Catalysis
After an overview of chiral urea and thiourea synthetic methods, this review describes the main applications of urea and thiourea complexes in...
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Syntheses of quinolines and their derivatives from α,β-unsaturated aldehydes
The methods for the synthesis of quinoline and its hydrogenated derivatives from α,β-unsaturated aldehydes have been summarized for the first time....
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Progress in organocatalytic asymmetric (4+3) cycloadditions for the enantioselective construction of seven-membered rings
Chiral seven-membered ring systems such as seven-membered carbocycles and heterocycles are widely found in natural products and pharmaceuticals....
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Recent Advances of Asymmetric Catalysis in Flow for Drug Discovery
Enantioselective continuous-flow catalysis enables highly efficient synthesis of optically active compounds. The early examples of this field were...
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An efficient three-component synthetic protocol for the synthesis of structurally diverse spiroannulated benzothiazolopyrimidines catalyzed by l-proline in aqueous media
An environmentally sustainable domino protocol has been presented to synthesize structurally diverse...
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Diastereodivergent synthesis of enantioenriched α,β-disubstituted γ-butyrolactones via cooperative N-heterocyclic carbene and Ir catalysis
The stereodivergent synthesis of natural product frameworks via a single transformation using simple starting materials is a significant challenge....
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N-heterocyclic carbene-catalyzed atroposelective synthesis of axially chiral 5-aryl 2-pyrones from enals
Axially chiral molecules have been widely used in inorganic, material and medicinal chemistry. Compared with well-established N-heterocyclic carbene...
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Recent Trends in Photocatalytic Enantioselective Reactions
Enantioselective synthesis through photocatalysis is one of the highly preferred approaches towards preparation of optically active compounds. This...
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Organocatalytic asymmetric [2 + 2] cycloaddition of alkynes with quinones
A chiral phosphoric acid catalyzed enantioselective [2 + 2] cycloaddition of alkynylindols or alkynylnaphthols with quinones is disclosed. A class of...
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Synthesis of 3-spiro-annulated pyrrolidine-2-thiones (microreview)
In this microreview we provide general information on synthetic methods published over the previous 10 years providing access to a promising group of...
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N-Heterocyclic carbene-catalyzed enantioselective (dynamic) kinetic resolutions and desymmetrizations
N -heterocyclic carbene-catalyzed enantioselective kinetic resolutions, dynamic kinetic resolutions, and desymmetrization reactions are systematically...
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Recent Advances in Palladium-Catalyzed [4 + n] Cycloaddition of Lactones, Benzoxazinanones, Allylic Carbonates, and Vinyloxetanes
Palladium-catalyzed allylation cyclization reaction has recently emerged as an efficient and powerful synthetic platform for the construction of...
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Effect of Calix[4]arene as a Hydrophobic Substituent on Proline Catalysis of Direct Asymmetric Aldol Reactions in the Presence of Water
AbstractA new organocatalyst trans -4-hydroxy-L-proline-derived calix[4]arene was synthesized and its catalyst performance for the direct asymmetric...
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Organocatalytic aromatization-promoted umpolung reaction of imines
The umpolung functionalization of imines bears vast synthetic potential, but polarity inversion is less efficient compared with the carbonyl...
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Discovery and synthesis of atropisomerically chiral acyl-substituted stable vinyl sulfoxonium ylides
Atropisomerism is a type of conformational chirality that plays a critical role in various fields of chemistry, including synthetic, medicinal and...
