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Combinatorial strategies for production improvement of anti-tuberculosis antibiotics ilamycins E1/E2 from deep sea-derived Streptomyces atratus SCSIO ZH16 ΔilaR
Ilamycins E 1 /E 2 are novel cyclic heptapeptides from Streptomyces atratus SCSIO ZH16, which have the MIC value of 9.8 nM against Mycobacterium...
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Nanotechnology in TB Diagnosis
Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis (Mtb), is still a significant worldwide health issue, and it is the second...
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Discovery of novel and potent InhA direct inhibitors by ensemble docking-based virtual screening and biological assays
Multidrug-resistant tuberculosis (MDR-TB) continues to spread worldwide and remains one of the leading causes of death among infectious diseases. The...
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Recent Developments in Medicinal and In Silico Applications of Imidazopyridine Derivatives: Special Emphasis on Malaria, Trypanosomiasis, and Tuberculosis
People from low-income countries are increasingly affected by neglected communicable diseases, and the health care system frequently overlooks their...
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Plant Secondary Metabolites as a Source of New Drugs
An increasing number of new pathogens, the emergence of multidrug drug-resistant (MDR) and extremely drug-resistant (XDR) bacterial and fungal...
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Nanotechnology-Based Vaccination for TB
With a projected global target to end the tuberculosis epidemic by the year 2030, United Nations termed this as an important Sustainable Development...
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Designing of a Chimeric Vaccine Using EIS (Rv2416c) Protein Against Mycobacterium tuberculosis H37Rv: an Immunoinformatics Approach
Mycobacterium tuberculosis (Mtb) is a respiratory pathogen that causes tuberculosis (TB). There are a large number of proteins that are involved in...
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Multiple 3D- and 2D-quantitative structure–activity relationship models (QSAR), theoretical study and molecular modeling to identify structural requirements of imidazopyridine analogues as anti-infective agents against tuberculosis
Tuberculosis (TB), an infectious remains a global health burden till date. Considering immense importance of theoretical tools in computer aided-drug...
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Synthesis, Antitubercular Evaluation, Molecular Docking Study, and Teratogenicity Studies of Novel Triazolo Quinazoline Hybrids
AbstractA novel series of triazole-quinazoline hybrid molecules was synthesized and characterized by spectral analyses. The H37 R V strain was used...
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Antimicrobial Potentials of Zinc and Iron Oxide Nanoparticles
One of the most important issues in global healthcare is the development of antimicrobial or antibiotic resistance (AMR or ABR) in microorganisms....
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Comparison of Multi-metallic Nanoparticles-Alternative Antibacterial Agent: Understanding the Role of Their Antibacterial Properties
The rise of antibiotic-resistant infectious diseases caused by various bacterial pathogens has emerged as a major global health concern. As a result,...
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Secondary Metabolites: Treasure Trove for Future Medicine
Secondary metabolites are organic substances produced by various living organisms (e.g., bacteria, fungi, plants, animals) that do not have any...
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Microbicidal Nanoparticles
Nanomaterials exhibit tremendous exciting properties and transform every aspect of science and technology. Microbiology has also not remained...
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Extensively Drug-resistant Tuberculosis (XDR-TB)-inhibitors to Overcome the Scourge of Drug-resistant Tuberculosis: a Perspective
AbstractTB is the 9th leading cause of death worldwide above HIV/AIDS. Tuberculosis (TB) management remains challenging due to the emergence of...
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Mucosal Targeting Strategies for Antiviral Drug Delivery
Antiviral drug efficacy and bioavailability are critical factors in the treatment of viral infections. The existence of new viral infections...
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Polymer-Based Nanotechnology to Combat the Emergence of Drug Resistance in Bacteria
Multidrug-resistant bacteria are posing a great threat to human beings. To address that challenge, polymer-based nanomaterials have come into the...
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Exploring biogenic chalcones as DprE1 inhibitors for antitubercular activity via in silico approach
Cases of drug-resistant tuberculosis (TB) have increased worldwide in the last few years, and it is a major threat to global TB control strategies...
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Marine Pharmacology: Potentialities in the Treatment of Infectious Diseases, Osteoporosis and Alzheimer's Disease
Several molecules isolated from various marine organisms (microorganisms, algae, fungi, invertebrates, and vertebrates) are currently under study...
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Exploring Microbial Nanotoxicity Against Drug Resistance in Bacteria
The growing threat of antimicrobial resistance on human health urgently calls for the need to look for novel solutions to mitigate the grave effect...
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Zinc Oxide Nanoparticles in Biomedical Applications: Advances in Synthesis, Antimicrobial Properties, and Toxicity Considerations
Zinc oxide (ZnO) nanoparticles are promising nanotherapeutics used in several biomedical applications. Some of the unique features of ZnO...