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Biotransformation to synthesize the methylated derivatives of baicalein using engineered Escherichia coli
Oroxylin A and negletein are flavonoid compounds existing in plants, with excellent pharmacological activities such as anti-inflammatory,...
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Circulating tumor cell-derived exosome–transmitted long non-coding RNA TTN-AS1 can promote the proliferation and migration of cholangiocarcinoma cells
BackgroundExosomes assume a pivotal role as essential mediators of intercellular communication within tumor microenvironments. Within this context,...
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Potential therapeutic effects of milk-derived exosomes on intestinal diseases
Exosomes are extracellular vesicles with the diameter of 30 ~ 150 nm, and are widely involved in intercellular communication, disease diagnosis and...
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Microfluidic Approach for Modeling Coupled Circadian Clock
In mammals, it is believed that the intercellular coupling mechanism between neurons in the suprachiasmatic nucleus (SCN) confers circadian... -
Improving Intestinal Barrier Function in Sepsis by Partially Hydrolysed Guar Gum via the Suppression of the NF-κB/MLCK Pathway
Partially hydrolyzed guar gum (PHGG) protects against intestinal barrier dysfunction and can ameliorate some intestinal diseases. However, whether...
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Degenerated nucleus pulposus cells derived exosome carrying miR-27a-3p aggravates intervertebral disc degeneration by inducing M1 polarization of macrophages
BackgroundIntervertebral disc degeneration (IVDD) is a major contributor to spinal disorders. Previous studies have indicated that the infiltration...
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Ginseng-derived nanoparticles alleviate inflammatory bowel disease via the TLR4/MAPK and p62/Nrf2/Keap1 pathways
Inflammatory bowel disease (IBD) is closely linked to the homeostasis of the intestinal environment, and exosomes can be used to treat IBD due to...
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Vacuum Impregnation Process and Its Potential in Modifying Sensory, Physicochemical and Nutritive Characteristics of Food Products
The augmented promotion and consumer awareness of healthy eating and lifestyle have resulted in extensive growth of the functional food market in...
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Uptake and anti-inflammatory effects of liposomal astaxanthin on endothelial cells tracked by Raman and fluorescence imaging
AbstractAstaxanthin (AXT) is a lipophilic antioxidant and anti-inflammatory natural pigment whose cellular uptake and bioavailability could be...
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Isobavachalcone attenuates TNF-α-induced ICAM-1 and VCAM-1 expression in human umbilical vein endothelial cells by regulating the NF-κB signaling pathway
Vascular inflammation activated by pro-inflammatory cytokines is an inflammatory response that occurs in the early stages of atherosclerosis....
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Extracellular vesicles involved in growth regulation and metabolic modulation in Haematococcus pluvialis
BackgroundMicroalgae-derived extracellular vesicles (EVs), which transfer their cargos to the extracellular environment to affect recipient cells,...
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Strategies for monitoring cell–cell interactions
Multicellular organisms depend on physical cell–cell interactions to control physiological processes such as tissue formation, neurotransmission and...
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Sesquiterpenoid-rich Java Ginger rhizome extract prompts autophagic cell death in cervical cancer cell SiHa mainly by modulating cellular redox homeostasis
Java Ginger or Curcuma zanthorrhiza Roxb. has long gained focus among tribal people of Java, for its medicinal properties mainly against...
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Exo-III Enzyme and DNAzyme-Assisted Dual Signal Recycles for Sensitive Analysis of Exosomes by Using Personal Glucose Meter
Exosome plays a crucial role in regulating intercellular communication during atherosclerosis development. However, sensitive and portable exosome...
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Exosome-derived circ_0001785 delays atherogenesis through the ceRNA network mechanism of miR-513a-5p/TGFBR3
PurposeEndothelial cell dysfunction is a major cause of early atherosclerosis. Although the role of extracellular vesicles in stabilizing...
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Therapeutic potential and mechanisms of mesenchymal stem cell-derived exosomes as bioactive materials in tendon–bone healing
Tendon–bone insertion (TBI) injuries, such as anterior cruciate ligament injury and rotator cuff injury, are the most common soft tissue injuries. In...
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Enhancing the Therapeutic Potential of Extracellular Vesicles Using Peptide Technology
Extracellular vesicles are lipid-bilayer-enclosed nanoparticles present in the majority of biological fluids that mediate intercellular... -
Exosome-associated host–pathogen interaction: a potential effect of biofilm formation
Exosomes being non-ionized micro-vesicles with a size range of 30–100 nm possess the ability to bring about intracellular communication and...
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Sparse autoencoder–based feature extraction from TOF–SIMS image data of human skin structures
Time-of-flight secondary ion mass spectrometry (TOF–SIMS) is a useful and versatile tool for surface analysis, enabling detailed compositional...
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Artificial Exosomes as Targeted Drug Delivery Systems
Exosomes are biological extracellular vesicles that are released by both prokaryotic and eukaryotic cells. Their size ranges between 40 and 160 nm,...