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1. Role of Herbal Medicines in the Management of Brain Injury

   Brain is susceptible to oxidative stress due to its increased oxygen consumption and low antioxidant levels. Oxidative stress plays a crucial role in...

   Mohammad Reza Safdari, Farzaneh Shakeri, ... Amirhossein Sahebkar in Natural Products and Human Diseases

   Chapter 2021
   

2. Omega-3 Fatty Acids and Ageing Brain

   Inflammation plays a key role in the pathogenesis of age-related brain diseases. Hence, it is appropriate to target inflammation for disease...

   Navya Sree Boga, Sanjay Basak in Evidence-based Functional Foods for Prevention of Age-related Diseases

   Chapter 2023
   

3. The Phytoestrogenic Effect of Hibiscus sabdariffa Involves Estrogen Receptor α in Ovariectomized Wistar Rats

   The calyxes of Hibiscus sabdariffa present multiple pharmacological effects primarily attributed to their high anthocyanin content; however, little...

   Gerardo Lorenzana-Martínez, César Alejandro San Juan-García, ... Jacinto Bañuelos-Pineda in Plant Foods for Human Nutrition

   Article 14 June 2023
   

4. Enhanced antidepressant effects of BDNF-quercetin alginate nanogels for depression therapy

   Background

   Brain-derived neurotrophic factor (BDNF) with neuronic development and function is a promising therapeutic agent for treating depressive...

   Dong Xu, Li-Na Gao, ... Qiangsong Wang in Journal of Nanobiotechnology

   Article Open access 18 October 2023
   

5. Intranasal Nose-to-Brain Drug Delivery via the Olfactory Region in Mice: Two In-Depth Protocols for Region-Specific Intranasal Application of Antibodies and for Expression Analysis of Fc Receptors via In Situ Hybridization in the Nasal Mucosa

   A region-specific catheter-based intranasal administration method was successfully developed, established, and validated as reported previously. By...

   Helena Herzog, Sara Glöckler, ... Katharina Schindowski in Tau Protein

   Protocol 2024
   

6. Chrysophanol improves memory impairment and cell injury by reducing the level of ferroptosis in Aβ_25–35 treated rat and PC12 cells

   Alzheimer’s disease (AD) is a common age-related chronic and neurodegenerative disease that has become a global health problem. AD pathogenesis is...

   **g Luo, Qingyang Lu, ... Wenwen Si in 3 Biotech

   Article 28 September 2023
   

7. Inhibition of FLT1 Attenuates Neurodevelopmental Abnormalities and Cognitive Impairment in Offspring Caused by Maternal Prenatal Stress

   Fms-like tyrosine kinase 1 (FLT1) has been shown to regulate processes such as angiogenesis, neurogenesis, and cognitive impairment. However, the...

   Huifang Zhang, Yudan Zhang, ... Hui Li in Applied Biochemistry and Biotechnology

   Article 18 November 2023
   

8. The Role of Nrf2-ARE Signaling Pathway and Tatarinow Sweetflag Extract to Regulate the Acute Phase of Pilocarpine-Induced Epilepsy in Juvenile Rats

   To analyze the role of Nrf2-ARE signaling pathway in the regulation of the acute phase of pilocarpine-induced epilepsy in juvenile rats by Tatarinow...

   Guanghui **, Zhuo Wang, ... Guyue Li in Molecular Biotechnology

   Article 25 October 2023
   

9. Stem Cells in CNS and Cardiac Regeneration

   The central nervous system (CNS) and the heart muscle regenerate poorly after injury, yet evidence is mounting that both harbor cells capable of...

   David L. Stocum in Regenerative Medicine I

   Chapter
   

10. Exposure to two-dimensional ultrathin Ti₃C₂ (MXene) nanosheets during early pregnancy impairs neurodevelopment of offspring in mice

    Background

    Two-dimensional ultrathin Ti ₃ C ₂ (MXene) nanosheets have been extensively explored for various biomedical applications. However, safety...

    Yixian Wen, Le Hu, ... Xueqing Liu in Journal of Nanobiotechnology

    Article Open access 05 March 2022
    

11. Improvement effects of cyclic peptides from Annona squamosa on cognitive decline in neuroinflammatory mice

    Cyclic peptides can resist enzymatic hydrolysis to pass through the intestine barrier, which may reduce the risk of mild cognition decline. But...

    Bo Li, Xueying Shi, ... **aocui Wu in Food Science and Biotechnology

    Article 26 November 2023
    

12. Brain-targeted nanoreactors prevent the development of organophosphate-induced delayed neurological damage

    Background

    Organophosphate (OP)-induced delayed neurological damage is attributed to permanent neuropathological lesions caused by irreversible...

    Shuaijun Zou, Qianqian Wang, ... Liming Zhang in Journal of Nanobiotechnology

    Article Open access 07 August 2023
    

13. Modeling Anorexia Nervosa

    Although the pathophysiology underlying anorexia nervosa (AN) has not been fully elucidated, inflammation appears to be a critical component of its...

    Maria Scherma, Roberto Collu, ... Paola Fadda in Eating Disorders

    Reference work entry 2023
    

14. Comparative evaluation of natural neuroprotectives and their combinations on chronic immobilization stress-induced depression in experimental mice

    The present study evaluates the potential of neuroprotective phytochemicals-rutin (R), resveratrol (Res), 17β-estradiol (17β-E2), and their different...

    Ibrahim M. Ibrahim, Mohammed Alsieni, ... Vinay Kumar in 3 Biotech

    Article 22 December 2022
    

15. An Introduction: Overview of Nervous System and Brain Disorders

    Cells are the basic structural and functional units of living organisms, enabling a living being to perform a particular task or governing a specific...

    Maria Ayub, Antonello Mallamaci in The Role of Natural Antioxidants in Brain Disorders

    Chapter 2023
    

16. Dehydrozingerone protects temozolomide-induced cognitive impairment in normal and C6 glioma rats besides enhancing its anticancer potential

    Considering the cognitive impairment induced by temozolomide (TMZ) in glioblastoma survivors, the present study was aimed to evaluate the protective...

    Nandini Pathak, Sri Pragnya Cheruku, ... Nitesh Kumar in 3 Biotech

    Article Open access 17 September 2020
    

17. Age-Related Neurodegenerative Diseases

    Aging is one of the major risk factors for several neurodegenerative diseases, the most common being Alzheimer’s and Parkinson’s diseases. Besides...

    Narmadhaa Sivagurunathan, Latchoumycandane Calivarathan in Evidence-based Functional Foods for Prevention of Age-related Diseases

    Chapter 2023
    

18. Characterization of N-glycome profile in mouse brain tissue regions by MALDI-TOF/MS

    Glycosylation is one of the most common types of post-translational modifications in mammals. It is well known that N-glycans play a key role in cell...

    Yuanyuan Liu, Yutong Han, ... **n Liu in Analytical and Bioanalytical Chemistry

    Article 15 July 2023
    

19. Application of Lineage Tracing in Central Nervous System Development and Regeneration

    The central nervous system (CNS) is a complicated neural network. The origin and evolution of functional neurons and glia cells remain unclear, as do...

    Hao Li, Yuan Zhuang, ... Baiyun Liu in Molecular Biotechnology

    Article Open access 19 June 2023
    

20. Cellular and Neurological Effects of Lead (Pb) Toxicity

    Lead (Pb2+), a naturally occurringNeurological effects common heavy metalMetal found in the earth’s crust, replaces other cations in living...

    Shubham Gudadhe, Sushma Kumari Singh, Jawaid Ahsan in Lead Toxicity Mitigation: Sustainable Nexus Approaches

    Chapter 2024