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1. Exploring the Chemical Space of Proluciferins as Probe Substrates for Human Cytochrome P450 Enzymes

   We report the synthesis of 21 new proluciferin compounds that bear a small aliphatic ether group connected to the 6’ hydroxy function of firefly...

   Jie Zhao, Xue Zhang, ... Matthias Bureik in Applied Biochemistry and Biotechnology

   Article 26 October 2022
   

2. Regiospecific C–H amination of (−)-limonene into (−)-perillamine by multi-enzymatic cascade reactions

   Background

   (−)-Limonene, one of cyclic monoterpenes, is an important renewable compound used widely as a key building block for the synthesis of new...

   Yue Ge, Zheng-Yu Huang, ... Jian-He Xu in Bioresources and Bioprocessing

   Article Open access 26 August 2022
   

3. Efficiency of Ionic Liquids–Based Aqueous Two-phase Electrophoresis for Partition of Cytochrome c

   Cytochrome c is a small water-soluble protein that is abundantly found in the mitochondrial intermembrane space of microorganism, plants and...

   Phei Er Kee, John Chi-Wei Lan, ... Hui-Suan Ng in Applied Biochemistry and Biotechnology

   Article 06 January 2020
   

4. Chemodivergent C(sp³)–H and C(sp²)–H cyanomethylation using engineered carbene transferases

   The ubiquity of C–H bonds presents an opportunity to efficiently elaborate and build complexity in organic molecules. Methods for selective...

   Juner Zhang, Ailiena O. Maggiolo, ... Frances H. Arnold in Nature Catalysis

   Article 19 January 2023
   

5. Enantioselective oxidation of unactivated C–H bonds in cyclic amines by iterative docking-guided mutagenesis of P450_BM3 (CYP102A1)

   Selective oxidation of ring C–H bonds is an attractive route to functionalized cyclic amines, which are versatile intermediates in drug synthesis and...

   Yuan Zhang, Ziyue **ong, ... Luet L. Wong in Nature Synthesis

   Article 29 September 2022
   

6. Modeling of Drug-Drug Interactions between Omeprazole and Erythromycin in the Cytochrome P450-Dependent System In vitro

   Abstract

   In the present study an electrochemical system based on recombinant cytochrome P450 3A4 (CYP3A4) has been developed for analysis of potential...

   P. I. Koroleva, A. V. Kuzikov, ... V. V. Shumyantseva in Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry

   Article 01 January 2021
   

7. Biocatalytic enantioselective γ-C–H lactonization of aliphatic carboxylic acids

   Enantioselective γ-lactonization of unactivated C( sp ³ )–H bonds of aliphatic carboxylic acids is a synthetic challenge. Without using directing...

   Qian Ma, Wenhao Shan, ... **qing Wang in Nature Synthesis

   Article 06 November 2023
   

8. Machine learning to predict metabolic drug interactions related to cytochrome P450 isozymes

   Drug–drug interaction (DDI) often causes serious adverse reactions and thus results in inestimable economic and social loss. Currently, comprehensive...

   Ning-Ning Wang, **ang-Gui Wang, ... Dong-Sheng Cao in Journal of Cheminformatics

   Article Open access 15 April 2022
   

9. Author Correction: A cytochrome c is the natural electron acceptor for nicotine oxidoreductase

   A Correction to this paper has been published: https://doi.org/10.1038/s41589-021-00756-z.

   Mark Dulchavsky, Christopher T. Clark, ... Frederick Stull in Nature Chemical Biology

   Article 04 February 2021

10. “French fries”-like luminescent metal organic frameworks for the fluorescence determination of cytochrome c released by apoptotic cells and screening of anticancer drug activity

    A luminescent metal organic framework was prepared by encapsulating Zn–Ag–In–S quantum dots into “French fries”-like MIL-68(In) metal organic...

    Ruirui **e, Yanyan Liu, ... Peng Zhao in Microchimica Acta

    Article 12 March 2020
    

11. Substrate sulfoxidation by a biomimetic cytochrome P450 Compound I mimic: How do porphyrin and phthalocyanine equatorial ligands compare?

    The cytochrome P450 enzymes are important enzymes in the liver that trigger drug metabolism reactions. In biotechnology and biomimetic chemistry,...

    Saaid Roach, Abayomi S Faponle, ... Sam P de Visser in Journal of Chemical Sciences

    Article 18 June 2021
    

12. Three-dimensional saturated C(sp³)-rich bioisosteres for benzene

    Benzenes, the most ubiquitous structural moiety in marketed small-molecule drugs, are frequently associated with poor ‘drug-like’ properties,...

    Jet Tsien, Chao Hu, ... Tian Qin in Nature Reviews Chemistry

    Article 09 July 2024
    

13. The benefits of mixed-mode chromatography columns for separation of peptides and protein digests

    In this work, the evaluation and comparison of mixed-mode chromatography and reversed-phase chromatography for separation of peptides and protein...

    Zuzana Kadlecová, Hana Boudová, Květa Kalíková in Monatshefte für Chemie - Chemical Monthly

    Article Open access 08 June 2023
    

14. Optimisation of Cytochrome P450 BM3 Assisted by Consensus-Guided Evolution

    Cytochrome P450 enzymes have attracted much interest over the years given their ability to insert oxygen into saturated carbon-hydrogen bonds, a...

    Thierry Vincent, Bruno Gaillet, Alain Garnier in Applied Biochemistry and Biotechnology

    Article 16 April 2021
    

15. Stereoselective construction of β-, γ- and δ-lactam rings via enzymatic C–H amidation

    Lactam rings are found in many biologically active natural products and pharmaceuticals, including important classes of antibiotics. Methods for the...

    Satyajit Roy, David A. Vargas, ... Rudi Fasan in Nature Catalysis

    Article 06 December 2023
    

16. Identification of a resonance Raman marker for cytochrome to monitor stress responses in Escherichia coli

    Raman spectroscopy and resonance Raman spectroscopy are widely used to study bacteria and their responses to different environmental conditions. In...

    Ria Mukherjee, Taru Verma, ... Siva Umapathy in Analytical and Bioanalytical Chemistry

    Article 17 June 2020
    

17. Mechanistic and structural characterization of an iridium-containing cytochrome reveals kinetically relevant cofactor dynamics

    Artificial metalloenzymes (ArMs), which contain non-native, typically synthetic, metal cofactors, are a flourishing class of biocatalyst for...

    Brandon J. Bloomer, Sean N. Natoli, ... John F. Hartwig in Nature Catalysis

    Article 12 January 2023
    

18. ε-Poly-L-lysine-protected Ti₃C₂ MXene quantum dots with high quantum yield for fluorometric determination of cytochrome c and trypsin

    Titanium carbide quantum dots functionalized with ε-poly-L-lysine (PLL) were synthesized by sonication cutting and hydrothermal synthesis. The...

    Mingwang Liu, Ji Zhou, ... Gongwu Song in Microchimica Acta

    Article 12 November 2019
    

19. Scalable production and application of Pichia pastoris whole cell catalysts expressing human cytochrome P450 2C9

    Background

    Currently, the numerous and versatile applications in pharmaceutical and chemical industry make the recombinant production of cytochrome...

    Javier Garrigós-Martínez, Astrid Weninger, ... Xavier Garcia-Ortega in Microbial Cell Factories

    Article Open access 26 April 2021
    

20. Exploring azomethine ylides reactivity with acrolein through cycloaddition reaction and computational antiviral activity assessment against hepatitis C virus

    Context

    The regioselectivity and diastereoselectivity of the 1,3-dipolar cycloaddition reaction between azomethine ylides and acrolein were...

    Oumayma Abdessadak, Pankaj Kandwal, ... Mohammed Bouachrine in Journal of Molecular Modeling

    Article 05 January 2024