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Synthesis of medium-sized benzo[b]azocines and benzo[b]azonines by photoinduced 8-/9-endo sulfonyl-cyclization
An efficient photochemical radical sulfonyl cyclization of designed dienes to medium-sized benzo[ b ]azocines and benzo[ b ] azonines was developed. This...
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Synthesis of New Sulfonic Acid Derivatives by the Reaction of S-(1S,2R,3S,5R)-2-Formyl-6,6-dimethylnorpinan-3-yl Thioacetate with Chlorine Dioxide
AbstractNew polyfunctional compounds of the pinane series, 2-carboxy-3-thioacetate, 2-carboxy-3-sulfonyl chloride, and 2-carboxy-3-sulfonic acid that...
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N-glycoside synthesis through combined copper- and photoredox-catalysed N-glycosylation of N-nucleophiles
State-of-the-art glycosylation methods primarily rely on ionic reactions of heteroatomic nucleophiles with electrophilic glycosyl oxocarbenium...
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Oxidative Cross-Coupling of Cysteamine with Secondary Phosphine Chalcogenides: Aspects of Reaction Chemoselectivity
AbstractCysteamine (2-aminoethanethiol) undergoes oxidative cross-coupling with secondary phosphine sulfides and phosphine selenides under mild...
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Enantioselective synthesis of atropisomeric indoles via iron-catalysed oxidative cross-coupling
Heterobiaryl compounds that exhibit axial chirality are of increasing value and interest across several fields, but direct oxidative methods for...
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Programmable late-stage functionalization of bridge-substituted bicyclo[1.1.1]pentane bis-boronates
Modular functionalization enables versatile exploration of chemical space and has been broadly applied in structure–activity relationship (SAR)...
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Chemodivergent C(sp3)–H and C(sp2)–H cyanomethylation using engineered carbene transferases
The ubiquity of C–H bonds presents an opportunity to efficiently elaborate and build complexity in organic molecules. Methods for selective...
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Ni-catalysed assembly of axially chiral alkenes from alkynyl tetracoordinate borons via 1,3-metallate shift
Asymmetric synthesis based on a metallate shift of tetracoordinate borons is an intriguing and challenging topic. Despite the construction of central...
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Metalloradical approach for concurrent control in intermolecular radical allylic C−H amination
Although they offer great potentials, the high reactivity and diverse pathways of radical chemistry pose difficult problems for applications in...
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Photochemical diversification of strong C(sp3)–H bonds enabled by allyl bromide and sodium fluoride
The development of practical approaches for the selective functionalization of strong, neutral C( sp 3 )–H bonds, such as those in petroleum-derived...
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Regioselective access to polycyclic N-heterocycles via homogeneous copper-catalyzed cascade cyclization of allenynes
Polycyclic N-heterocycles are important structural motifs commonly found in bioactive compounds, however, their selective construction via the...
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Specific cross-dimerization of terminal alkynes via Pd/TMEDA catalysis
The cross-dimerization of terminal alkynes is the most straightforward and attractive approach to differently substituted 1,3-enynes, which are vital...
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A boryl-migratory semipinacol rearrangement
The semipinacol rearrangement is one of the classic yet useful synthetic tools in organic synthesis. However, semipinacol rearrangements involving...
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Rhodium-catalyzed enantio- and diastereoselective carboamidation of bicyclic olefins toward construction of remote chiral centers and axis
The precise control of multiple chiral elements through a single step catalytic process remains a significant challenge in asymmetric catalysis....
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Mechanistic Study of Organocatalytic Chemoselective Monoacylation of 1,5-Pentanediol
Fine molecular transformation is one of the fundamental challenges in organic synthesis. Kawabata and co-workers have developed various acylative... -
Radical thioesterification via nickel-catalysed sensitized electron transfer
Multi-catalytic reaction modes have attracted widespread attention in synthetic chemistry. The merger of nickel catalysis with photoredox catalysis...
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Nanocrystals perovskites photocatalyzed singlet oxygen generation for light-driven organic reactions
Lead halide perovskite nanocrystals were prepared and used as photocatalysts for the in situ 1 O 2 generation to perform hetero Diels–Alder, ene and...
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A molecular electron density theory investigation of the molecular mechanism, regioselectivity, stereoselectivity and chemoselectivity of cycloaddition reaction between acetonitrile N-oxide and 2,5-dimethyl-2H-[1,2,3]diazarsole
The cycloaddition reactions (32CA) of acetonitrile N-oxide and 2,5-dimethyl-2H-[1,2,3]diazarsole 1 have been examined employing the molecular...
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Synthesis, X-ray structure, DFT investigation, and molecular docking of 1,3,5-tricyclohexyl-1,3,5-triazinane-2,4,6-trione, a cyclic polyamide with anti HIV-1 (RT), antiplatelet, and anticoagulant activities
1,3,5-tricyclohexyl-1,3,5-triazinane-2,4,6-trione ( TCy-TAZTO ) was obtained with high chemoselectivity and excellent yield, through an efficient and...
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Catalytic reductive desymmetrization of malonic esters
Desymmetrization of fully substituted carbons with a pair of enantiotopic functional groups is a practical strategy for the synthesis of quaternary...