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Tumor microenvironment reprogramming combined with immunogenic enhancement by nanoemulsions potentiates immunotherapy
The combination of immune checkpoint inhibitors and immunogenic cell death (ICD) inducers has become a promising strategy for the treatment of...
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TH-302-loaded nanodrug reshapes the hypoxic tumour microenvironment and enhances PD-1 blockade efficacy in gastric cancer
BackgroundHypoxia, a common characteristic of the tumour microenvironment, is involved in tumour progression and immune evasion. Targeting the...
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Irradiated microparticles suppress prostate cancer by tumor microenvironment reprogramming and ferroptosis
Immunogenic cell death (ICD) plays a crucial role in triggering the antitumor immune response in the tumor microenvironment (TME). Recently,...
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Quercetin-loaded mesoporous nano-delivery system remodels osteoimmune microenvironment to regenerate alveolar bone in periodontitis via the miR-21a-5p/PDCD4/NF-κB pathway
BackgroundImpaired osteo-/angiogenesis, excessive inflammation, and imbalance of the osteoimmune homeostasis are involved in the pathogenesis of the...
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Acidic and hypoxic tumor microenvironment regulation by CaO2-loaded polydopamine nanoparticles
Hypoxia and high accumulation of lactic acid in the tumor microenvironment provide fertile soil for tumor development, maintenance and metastasis....
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Zn-MOF hydrogel: regulation of ROS-mediated inflammatory microenvironment for treatment of atopic dermatitis
Atopic dermatitis (AD) is a chronic and recurrent inflammation disease associated with immune dysfunction. The high level of reactive oxygen species...
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Remodeling of tumor microenvironment for enhanced tumor chemodynamic/photothermal/chemo-therapy
The anticancer treatment is largely affected by the microenvironment of the tumors, which not only resists the tumors to the thermo/chemo-therapy,...
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The glycocalyx affects the mechanotransductive perception of the topographical microenvironment
The cell/microenvironment interface is the starting point of integrin-mediated mechanotransduction, but many details of mechanotransductive signal...
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Glioma-targeted oxaliplatin/ferritin clathrate reversing the immunosuppressive microenvironment through hijacking Fe2+ and boosting Fenton reaction
Glioma is easy to develop resistance to temozolomide (TMZ). TMZ-resistant glioma secretes interleukin-10 (IL-10) and transforming growth factor-β...
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Ag nanocomposite hydrogels with immune and regenerative microenvironment regulation promote scarless healing of infected wounds
BackgroundBacterial infection, complex wound microenvironment and persistent inflammation cause delayed wound healing and scar formation, thereby...
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Hydrogel microenvironment contributes to chemical-induced differentiation of mesenchymal stem cells: single-cell infrared microspectroscopy characterization
Stem cell microenvironment plays vital roles in directing cell proliferation and differentiation. Due to the tiny biochemical changes in the early...
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Development of a hypoxia-activated red-emission fluorescent probe for in vivo tumor microenvironment imaging and anti-tumor therapy
Hypoxia, a significant feature of the tumor microenvironment, is closely associated with tumor growth, metastasis, and drug resistance. In the field...
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Broadening the Scope of Biocatalysis Engineering by Tailoring Enzyme Microenvironment: A Review
The rational design of catalysts that fine-tune/mimics the enzyme microenvironment remains the subject of supreme interest. Several strategies moving...
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Metalloporphyrin-Based Biomimetic Catalysis: Applications, Modifications and Flexible Microenvironment Influences (A Review)
AbstractThe application of metalloporphyrin in the field of catalysis is one of the hotspots currently by the domestic and foreign scholars. The...
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Conversion of senescent cartilage into a pro-chondrogenic microenvironment with antibody-functionalized copper sulfate nanoparticles for efficient osteoarthritis therapy
The development of osteoarthritis (OA) correlates with the expansion of senescent cells in cartilage, which contributes to an inflammatory...
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Programmable DNA hydrogel provides suitable microenvironment for enhancing autophagy-based therapies in intervertebral disc degeneration treatment
The pathogenesis of intervertebral disc degeneration (IVDD) is attributed to metabolic dysregulation within the extracellular matrix and heightened...
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Nanotechnology-Based Approaches to Relieve Tumour Microenvironment Hypoxia via Enhanced Oxygen Delivery
Contemporary times have observed significant expression of the hypoxia-modulated tumorigenic microenvironment (TME) in facilitating the growth of...
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Alleviating the hypoxic tumor microenvironment with MnO2-coated CeO2 nanoplatform for magnetic resonance imaging guided radiotherapy
BackgroundRadiotherapy is a commonly used tool in clinical practice to treat solid tumors. However, due to the unique microenvironment inside the...
