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Sensitive and Fast Detection of Monoamines and Their Metabolites by High-Performance Liquid Chromatography Coupled with an Electrochemical Detector (HPLC-ECD) Under Isocratic Conditions: Application to Intracerebral Microdialysis in Mice Treated by Fluoxetine and Atomoxetine
Neurotransmitters (NTs) play a crucial role in brain function and associated with various neurological and neuropsychiatric disorders. This study...
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Hippocampal neurogenesis and Arc expression are enhanced in high-fat fed prepubertal female pigs by a diet including omega-3 fatty acids and Bifidobacterium breve CECT8242
PurposeObesity during childhood has become a pandemic disease, mainly caused by a diet rich in sugars and fatty acids. Among other negative effects,...
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Ishige foliacea ameliorates depressive-like behaviors in stress hormone treated mice
Chronic stress is an important factor to several physical and mental diseases. Ishige foliacea , an edible brown seaweed, has various biological...
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Light at night: effect on the daily clock, learning, memory, cognition, and expression of transcripts in different brain regions of rat
The rapid increase in urbanization is altering the natural composition of the day–night light ratio. The light/dark cycle regulates animal learning,...
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Effect of resveratrol and combination of resveratrol and donepezil on the expression of microglial cells and astrocytes in Wistar albino rats of colchicine-induced Alzheimer’s disease
AimThe goal was to evaluate the effect of resveratrol (RS) and combination therapy of RS and donepezil (DPZ), on the numerical expression of...
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Neuroprotective Effect of N-acetylcysteine Against Monocrotophos-Induced Oxidative Stress in Different Brain Regions of Rats
Monocrotophos (MCP) is systemic organophosphate insecticide used against crop pests. It is reported to cause mammalian toxicity through both acute...
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Long-term maintenance of synaptic plasticity by Fullerenol Ameliorates lead-induced-impaired learning and memory in vivo
Fullerenol, a functional and water-soluble fullerene derivative, plays an important role in antioxidant, antitumor and antivirus, implying its...
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Artificial night illumination disrupts sleep, and attenuates mood and learning in diurnal animals: evidence from behavior and gene expression studies in zebra finches
This study investigated the effects of an illuminated night on sleep, mood, and cognitive performance in non-seasonal diurnal zebra finches that were...
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Neuroprotective effect of Bis(Indolyl)phenylmethane in Alzheimer’s disease rat model through inhibition of hen Lysozyme amyloid fibril-induced neurotoxicity
Amyloid aggregates are the hallmarks of several disorders, including Huntington's, Parkinson's and Alzheimer's diseases. Compounds that could inhibit...
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In situ droplet-based on-tissue chemical derivatization for lipid isomer characterization using LESA
In this work, we present an in situ droplet-based derivatization method for fast tissue lipid profiling at multiple isomer levels. On-tissue...
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LA-ICP-MS bioimaging demonstrated disturbance of metal ions in the brain of Parkinson’s disease model mouse undergoing manganese-enhanced MRI
Manganese-enhanced MRI (MEMRI) is a powerful tool to study neuronal activity and microarchitecture in vivo . Yet the influence of exogenous manganese...
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Adenosine A2A Receptor Antagonists: Chemistry, SARs, and Therapeutic Potential
Many physiological processes are modulated by the naturally occurred nucleoside adenosine after interaction with four G-protein-coupled receptor...
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The Effect of Structural Analogues of Etimizole on Protein Kinase CK2, Protein Phosphorylation, and Transcription of Chromatin in Rat Cortical and Hippocampal Neurons
Abstract—The multifunctional protein kinase CK2 is an important enzyme in the nervous system. The nuclear forms of CK2 regulate chromatin structure...
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Desorption electrospray ionization (DESI) source coupling ion mobility mass spectrometry for imaging fluoropezil (DC20) distribution in rat brain
Fluoropezil (DC20) is a new selective acetylcholinesterase inhibitor, and it was developed for the treatment of Alzheimer’s disease patients. In this...
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Neuroanatomy and Neuropathology of Psychiatry Disorders
This comprehensive exploration delves into the intricate landscape of neuroanatomy and neuropathology in psychiatric disorders. The discussion...
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Rosmarinic acid suppresses tau phosphorylation and cognitive decline by downregulating the JNK signaling pathway
Rosmarinic acid (RA), a polyphenol found in Lamiaceae herbs, is a candidate of preventive ingredients against Alzheimer’s disease (AD) as it potently...
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Distribution of the Alpha-Synuclein in the Brain and the Primary Organs of the Rhesus Monkey
Previous studies have shown that abnormal aggregation of alpha-synuclein (α-syn) protein is a major trigger of neurodegenerative diseases. The...
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Human Nutritional Neuroscience: Fundamental Issues
Human Nutritional Neuroscience, an interdisciplinary field, delves into the intricate relationship between diet and brain health, exploring the...
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Antioxidant and angiotensin-I converting enzyme inhibitory peptides from Hippocampus abdominalis
Bioactive peptides isolated from edible marine sources have been used as nutraceuticals and functional foods. The present study focuses on the...
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Effects of lipoic acid supplementation on age- and iron-induced memory impairment, mitochondrial DNA damage and antioxidant responses
PurposeTo investigate the effects of lipoic acid (LA) supplementation during adulthood combined with supplementation later in life or LA...
